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Electricity spot prices are characterized by sudden large movements, followed a few days later by an equally large movement in the opposite direction. These phenomena are called spikes (upward movements) and drops (downward movements). Recent research has suggested that the dynamics of the electricity spot prices can be accurately described by hidden Markov Regime Switching (MRS) models. Regime sw

Rye products typically induce low insulin responses and appear to facilitate glucose regulation. The objective of this study was to investigate differences in postprandial glucose, insulin, and satiety responses between breads made from five rye varieties. Breads made from whole grain rye (Amilo, Rekrut, Dankowski Zlote, Nikita, and Haute Loire Pop) or a white wheat bread (WWB) were tested in a ra

Existing evidence on the effects of manganese and selenium during fetal life on neurodevelopmental disorders is inadequate. This study aims to investigate the hypothesized relationship between fetal exposure to manganese and selenium and attention deficit hyperactivity disorder (ADHD) diagnosis in childhood. Children born between 1978 and 2000 with ADHD (n=166) were identified at the Department of

Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of Hodgkin's lymphoma (HL) and demonstrated the association of common genetic variation for this type of cancer. Such evidence for inherited genetic risk is also provided by the family history and the very high concordance between monozygotic twins. However, little is known a

The human antimicrobial peptide cathelicidin LL-37 has, besides its antimicrobial properties, also been shown to regulate apoptosis in a cell type-specific manner. Mechanisms involved in LL-37-regulated apoptotic signaling are not identified. Here, we show that LL-37 reduces the human osteoblast-like MG63 cell number and cell viability in the micromolar concentration range with an IC(50) value of

Background: Hypertension and smoking are well-known risk factors for aortic dissection (AD), but it is unclear whether other lifestyle factors influence the risk. The aim of this study was to investigate the association between diet quality, physical activity, and risk of AD. Methods: The study included 28,094 participants from the Malmö Diet and Cancer Study, recruited between 1991 and 1996 and f

BackgroundTimely discharge of patients who are clinically ready to be discharged from hospitals to the next point of care is a common health system challenge. Ensuring safe and effective discharge holds new urgency, given the backlogs and increased waiting times for inpatient services in many countries after the COVID-19 pandemic.ObjectiveThe study aimed to identify policy options for addressing d

Context: Even within the physiological range, serum calcium (sCa++) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa2+ and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa2+ was measured in patients referre

Incretins such as glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play crucial roles in postprandial glucose management. Glucagon-like-peptide 1 and GIP stimulate insulin release in conjunction with meals and are responsible for up to 75% of the insulin secretion. Incretins are therefore very important for maintenance of normal blood glucose levels. Dairy foo

BACKGROUND: Recent advancements in single-cell transcriptomic analyses have greatly expanded our understanding of cellular diversity in adipose tissue, indicating transcriptionally distinct subpopulations of adipocytes. Here we sought to rigorously test such heterogeneity at the protein level.METHODS: A data-driven imaging platform was tailored to assess cellular protein levels based on immunofluo

Fatigue is common among adolescent girls, and iron deficiency is often considered a potential contributing factor. However, the association between iron status and self-reported fatigue in this population remains insufficiently understood. In a cross-sectional study of 485 post-menarchal girls aged 15-19 years, we examined associations between iron status, menstrual health, lifestyle factors, fati

Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk compared to those without diabetes. This shows an urgent need