Impaired insulin secretion from the pancreatic β-cells is central in the pathogenesis of type 2 diabetes (T2D), and microRNAs (miRNAs) are fundamental regulatory factors in this process. Differential expression of miRNAs contributes to β-cell adaptation to compensate for increased insulin resistance, but deregulation of miRNA expression can also directly cause β-cell impairment during the developm

Over the last decade, serial crystallography, a method to collect complete diffraction datasets from a large number of microcrystals delivered and exposed to an X-ray beam in random orientations at room temperature, has been successfully implemented at X-ray free-electron lasers and synchrotron radiation facility beamlines. This development relies on a growing variety of sample presentation method

The gap between theoretically predicted trade patterns and actual trade suggests that our understanding of what shapes trade patterns is incomplete. Institutional barriers may be one factor behind this gap, and recent research suggests that institutions are a greater obstacle to trade than tariffs. Using detailed firm-level data, we analyze how institutional quality in recipient countries affects

Purpose - The purpose of this paper is to describe a retrospective reflection over unconscious, emergent learning among employees of an organization and to suggest how to capture these moments of experiential learning for future organizational learning. Methodology - Action research in organizations is undertaken in interaction with the employees of the organization studied. The outcome is charact

Background: MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or inducing mRNA degradation. A number of computational techniques have been developed to identify the targets of miRNAs. In this study we used predicted miRNA-gene interactions to analyse mRNA

BACKGROUND-Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH-An expert committee compiled evidence-based recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality of

Onboardingprocessen finns till för att nyanställda ska introduceras till arbetsplatsen, arbetsverktygen, företagskulturen samt kollegorna på ett följsamt och strukturerat vis. Denna studie undersökte onboardingprocessen på ett litet- medelstort företag i en storstad i Sverige, i relation till medarbetarnas upplevelser av den. Syftet med studien var att besvara forskningsfrågan “På vilka sätt ger o

MÅL. För att svara på hur psykodynamisk psykoterapi av posttraumatiskt stressyndrom upplevdes bland flyktingar analyserades och jämfördes deras erfarenheter av grupp- och individuell psykoterapi. METOD. 10 tidigare patienter från en öppenvårdsmottagning specialiserad på behandling av patienter med erfarenheter av migration, krig och tortyr rekryterades till studien. 5 patienter hade gått i psykoan

Effective teaching and its impact on student outcome has been operationalized in previous research through formal measures and external observations, but also through measurements based on teacher self-reports. Thus, although the recipients of teaching are the students themselves, the students’ perceptions of effective teaching and teacher behaviors, and potential links to student academic outcome