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Cosmology concepts encompass complex spatial and temporal relations that are counterintuitive. Cosmology findings, because of their intrinsic interest, are often reported in the public domain with enthusiasm, and students come to cosmology with a range of conceptions some aligned and some at variance with the current science. This makes cosmology concepts challenging to teach, and also challenging

During the past decade, many parliamentary democracies have experienced bargaining delays when forming governments. The previous literature has attributed protracted government formation processes to a high degree of preference uncertainty among the political parties and a high level of bargaining complexity. The article draws on such theories, but also adds a third theoretical mechanism, commitme

Despite laws, policies, and political visions to create cities and societies for all, barriers still exclude people from using buildings and public places. The commitments made in global agreements such as the Convention on Rights for Persons with Disabilities (CRPD) and the 2030 Agenda for Sustainable Development require significant changes in urban planning to meet the variety of needs and condi

Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive

Bonus relations (such as step-grandparents, step-grandchildren, and families of choice) can be chosen, or they can be forced up on you, they can be regarded as very important to extremely peripheral. Bonus relations negotiate familiarity and can vary from inclusion to exclusion. Common to bonus-relations are their non-biological aspect: they are not blood-line relations, and to many families and fBonus relations (such as step-grandparents, step-grandchildren, and families of choice) can be chosen, or they can be forced up on you, they can be regarded as very important to extremely peripheral. Bonus relations negotiate familiarity and can vary from inclusion to exclusion. Common to bonus-relations are their non-biological aspect: they are not blood-line relations, and to many families and f

The Sustainable Business Model Canvas (SBMC) offers a useful tool for business model design, as it manages to integrate all three dimensions of sustainability without distinguishing between three different layers (economic, environmental, and social). This paper presents the application of SBMC in a real study case of a one-stop-shop (OSS) for the renovation of single-family houses operating inKro

Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how

Environmental exposure to noise and particle matter (PM) are risk factors for cardiovascular disease (CVD). Although there are often higher levels in occupational settings, little is known about noise and particle exposures at work and CVD risks. We investigated occupational noise and particle exposures and acute effects on pulse rate and blood pressure. 46 active, non-smoking, male construction w

Adipocyte dysfunction is a crucial driver of insulin resistance and type 2 diabetes. We identified EH domain-containing protein 2 (EHD2) as one of the most highly upregulated genes at the early stage of adipose tissue expansion. EHD2 is a dynamin-related ATPase influencing several cellular processes, including membrane recycling, caveolae dynamics and lipid metabolism. Here, we investigated the ro

Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur during prophase of the first meiotic division. Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic cross

The aim of this presentation is to examine the complex reception history of Astrid Lindgren's classic children's book “Pippi Longstocking” in the GDR based on the appearance and paper quality of the various editions. “Pippi Longstockning” was published in two different editions in 1975 and 1988 by the East Berlin Children's Book Publishing House (Kinderbuchverlag Berlin). The differences between t

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

Migratory routes and remote wintering quarters in birds are often species and even population specific. It has been known for decades that songbirds mainly migrate solitarily, and that the migration direction is genetically controlled. Yet, the underlying genetic mechanisms remain unknown. To investigate the genetic basis of migration direction, we track genotyped willow warblers Phylloscopus troc

In this article, we problematize the notion that the continuously growing use of bibliometric evaluation can be effectively explained by ‘neoliberal’ ideology. A prerequisite for our analysis is an understanding of neoliberalism as both denoting a more limited set of concrete principles for the organization of society (the narrow interpretation) or as a hegemonic ideology (the broad interpretation

Although there are some epigenome-wide association studies (EWAS) of insulin resistance, most of them did not replicate their findings and are focused in populations of European ancestry limiting the generalizability. In EPIPREG (294 Europeans and 162 South Asians), we conducted an EWAS of insulin resistance in maternal peripheral blood leukocytes, with replication in Born in Bradford (n=879; 430