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TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In patch-clamp bilayer recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), wa

Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell injury in several metabolic organs, we here investigate its role in the main cell types of vasculature. We depleted STK25 by small interfering RNA in hum

The infrastructure construction sector is a significant source of carbon emissions, and more stringent procurement requirements are central to meeting reduction targets in this demand-led and project-based industry. This paper aims to analyze the implementation of international policies for reducing carbon emissions in infrastructure construction, focusing on the interaction between policy ambitio

Accessibility today has a contradictory character. One the one hand, people with disabilities are welcomed and included, with ambitious promises in policies and declarations. On the other hand, they are still excluded in everyday practices. This volume explores this contradiction in three areas: city and transport, knowledge and education, and law, institutions and history. Sweden is the primary c

This thesis consists of four self-contained papers in applied microeconomics with family as a common theme. The first paper documents how the financial portfolios of parents change in response to the birth of a child. To identify dynamic effects around child birth, we use an event study approach with a matched treatment and control sample and a novel implementation of the same sex instrument. We f

Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is known to depend on complex interactions between genetic and environmental factors. Nevertheless, the mechanisms whereby environmental factors contribute to the pathogenesis of autoimmune diseases remain elusive and repr

Understanding the character of natural organic matter (NOM) and assessing its impact on water quality is paramount for managers of catchments and water utilities. For drinking-water producers, NOM affects disinfectant demand and the formation of by-products which can have adverse health effects. NOM content in raw waters also has an impact on water treatment processes by increasing required coagul

Lignin is one of the world's most abundant organic polymers, and 2-pyrone-4,6-dicarboxylate lactonase (LigI) catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) in the degradation of lignin. The pH has profound effects on enzyme catalysis and therefore we studied this in the context of LigI. We found that changes of the pH mostly affects surface residues, while the residues at the active

Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.

Background: In cardiovascular disease, prevention strategies targeting standard modifiable cardiovascular risk factors (SMuRFs; hypertension, diabetes, hypercholesterolaemia, and smoking) are crucial; however, myocardial infarction in the absence of SMuRFs is not infrequent. The outcomes of individuals without SMuRFs are not well known. Methods: We retrospectively analysed adult patients with firs