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Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion

In the last decades, the focus in waste and wastewater treatment systems has shifted towards increased recovery of energy and nutrients. Separation of urban food waste and domestic wastewaters using source control systems could aid this increase; however their effect on overall sustainability is unknown. To obtain indicators for sustainability assessments, five urban systems for collection, transp

Close collaboration is considered important; but is close collaboration for all purchases necessary to create value-in-production? In construction as well as in other industries, companies purchase a variety of items that require different amounts of attention to the relationship with suppliers. Buyer-supplier relationships are investigated in relation to how they bring value-in-production in the

This article addresses the follower-centric examination of the social construction of prophetic leadership roles. The central questions are: In what ways can key follower figures potentially exert independent agency and influence within the charismatic relationship?; What role might they play in the establishment and maintenance of the social construction of prophetic leadership roles? To these en

The main issues discussed in this dissertation are the questions how and why farming and animal husbandry were introduced in southern Scandinavia. The Löddesborg site by the Öresund coast supplied most of the basic materials used in the analysis. Simliar sites in Scania and Blekinge, as well as finds of Limhamn-axes, pointes butted axes, polygonal axes, and dolmens complete the picture of the neol

The Nordic countries have often been seen as “fore-runners” of energy efficiency in buildings in terms of both 1) the implementation of policy instruments and 2) the evaluation of actual effects. Since the 1970s, the Nordic countries have introduced a range of policy instruments for energy conservation in buildings. Interestingly, there are contrasting policy “styles” and experiences across the No

An enhanced dual-layer wide area wireless sensor network (WSN) system was developed and applied in fresh food tracking application. The sensor nodes of WSN provide a set of useful measurements about the environmental conditions during the fresh food transportation. Since the 3-axis acceleration data in such application account for more than 99% out of all collected source data, we propose a novel

In a recently conducted interview study, some survivors of traffic victims rate their home as the most important place for remembrance, compared to both the accident site and the burial plot. The reason for this evaluation appears to be the place’s ability to bring about a positive presence of the deceased. Supported by photographs and personal objects, the home serves as a constant reminder, and

The Nordic countries have often been seen as “fore-runners” of energy efficiency in buildings – in both the implementation of policy instruments and the evaluation of effects. Since the 1970s, the Nordic countries have introduced a range of policy instruments for energy conservation in buildings. The choice of instruments and experiences, however differs between countries. The aim of this study is

Vehicle-to-vehicle (VTV) communications are of interest for applications within traffic safety and congestion avoidance, but the development of suitable communications systems requires accurate models for the VTV propagation channel. This paper presents a new wideband MIMO (multipleinput- multiple-output) channel model for VTV channels based on extensive MIMO channel measurements performed at 5.2

The aim of this study was to visualize design regulations of furniture by means of interactive multimedia technology based on cognitive theories and practical examples. Furthermore, the usage of the visualized regulations to support education, communication, learnability, relevance and attitudes was evaluated. The visualized regulations were the result of a design process involving experts and pot

Hip fractures are a major cause of hospital stay among the elderly, and result in increased disability and mortality. In this study from 1 April 2003 to 31 March 2004, the influence of optimised treatment of hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year were investigated. Comparisons were made between the first 210 patients in the period and t

OBJECTIVE: This study was designed to investigate adult patients' perceptions of endotracheal tube (ETT)-related discomfort at 5 days and 2 months after discharge from the intensive care unit (ICU). METHODS: This prospective cohort study in 2 general ICUs included 250 intubated, mechanically ventilated adults admitted for more than 24 hours. Patients were interviewed 5 days and 2 months after disc

In modern industrialised society prepared meals and eating out of home is an increasing phenomenon. This develops new business opportunities for food manufacturers, since they need to create more convenience to the consumers through food that can be prepared and served quickly. However, the new food products require increased quality and safety and thereby more controlled distribution. The issue i