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Metformin is widely used in the treatment of type 2 diabetes to lower blood glucose. Although metformin is a relatively safe and effective drug, its clinical efficacy is variable and under certain circumstances it may contribute to life-threatening lactic acidosis. Thus, additional understanding of metformin pharmacokinetics and pharmacodynamics could provide important information regarding therap

Studiens syfte var att undersöka hur svenska elitlöpare i Sverige arbetar effektivt med målsättning och om det kan finnas ett samband mellan en effektiv målsättning och elitlöparens personlighet. Målsättning ses som en av de mest vanliga strategierna för att förbättra prestation, men alla vet inte hur de ska använda den för att maximera effekten i förhållande till individuella skillnader. 26 delta

This study focuses on the topic of Green IT in the IT consultant industry. Green IT is currently a hot topic but while awareness and established policies has increased in the last years, studies show that few companies are actually following their procedures or have goals or ways of measuring the effects of their green initiatives. The research area of Green IT is limited in terms of empirically f

I want to find out whether it is possible to draw any connection between payment behaviour and corporate reputation on a business-to-business level or whether it is rather trust that is effected and if so in both cases how and why. My qualitative research has an inductive approach and has been done by using an unstructured interview technique. I have used Chun’s definition of corporate reputation

Objective/methods DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese vs. obese individuals. Results We identified negatively correlated methylation and expression of seve

There is much concern about the effects of possible future climate changes on buildings. The future climate scenarios are based on numerical simulations. Each scenario of a climate model is the result of some changes in the boundary or initial conditions, emission scenario, etc. Consequently each weather scenario has different sources of uncertainty which affects the building simulation results. H

Objective: To compare telephone interview screening for child psychiatric/neuropsychiatric disorders using the inventory of Autism-Tics, Attention deficit/hyperactivity disorder (AD/HD) and other Comorbidities (A-TAC) with results from the Child Behavior Checklist (CBCL). Background: The A-TAC is a parent telephone interview focusing on autism spectrum disorders (ASDs) and co-existing problems, de

Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs,

Uppsatsens övergripande syfte är att strukturera och systematisera hur svensk rätt hanterar bodelningsavtal som har ingåtts på felaktiga antaganden. Ett bodelningsavtal är en produkt av två rättsområden: familjerätten och förmögenhetsrätten. Familjerätten tillhör privaträtten och innehåller regler som styr enskilda individers privatliv. Förmögenhetsrätten handlar om ekonomi och hur enskilda indivi

Despite the fact that Cesarean section (C-section) is the most commonly performed surgery in a number of industrialized countries, little is known about the long-term consequences for the mothers and children involved. In this study, I use a sample of high-risk births—namely, breech births, in which the fetus is presented with its head upward instead of downward—to study the causal effect of C-sec

Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, incl

Abstract: Citizen-state relations can be more than just a political relationship. It can also be emotional. Where there is an articulated balance between citizen tax obligations and state welfare services, there arises a combination of redistribution and reciprocity between citizen and state. This fiscal compact has an emotional component. This emotional component becomes indignation when people p

The paper starts from the hypothesis that materialist state theories (particularly Gramsci, Bourdieu and Poulantzas) and sustainable welfare approaches are capable of informing state-led ‘eco-social’ policy strategies that have the potential of overcoming the growth imperative in economy and society. It first outlines some general principles of such state action concerning economy, welfare, enviro