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Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GR
The growing implementation of sustainable urban infrastructure, utilizing solar energy for heat and power generation, daylighting, and thermal comfort, has intensified the focus on sustainability standards and guidelines. Nevertheless, a noticeable deficiency persists in regulations that specifically address solar energy access and protection, posing a barrier to the diffusion of solar-centric nei
Vaccine hesitancy is a significant concern worldwide. While some attribute it to a lack of knowledge, experiments have revealed that merely providing additional scientific information has little effect on vaccination hesitancy. This chapter aims to better understand negative and positive vaccination sentiments and actions by examining scientific findings’ non-random and non-linear influence on peo
The complex nature of climate change requires action at different scales and in different ways, but questions remain around how to produce climate action that is both multi-scalar and joined up. Here we explore this question by adopting a relational approach to studying climate action by faith-based actors, who increasingly play an active role campaigning on climate action. Drawing on qualitative
PurposeCare has been theorized as a relational practice, but the research has focused on providers rather than users. Older care users have been cast in a passive role, and their relational activities to help with the provision of their care or to support those who provide it are underexplored. The purpose of this study is to develop knowledge about home care use as a form of relational ‘work’.Met
The royal Danish-Norwegian flagship Gribshunden, launched in 1485, was amongthe earliest northern European warships purpose-built to carry artillery. However, King Hans employed his vessel as far more than a weapons platform. The ship was his ‘floating castle’, fulfilling all the various purposes of a land redoubt. At its loss in 1495 enroute to a political summit in Kalmar, where Hans expected to
Over the last seventy years, most European countries have undergone one or more transitions in home heating provision. Moving first away from burning solid fuels and towards communal or individual central heating systems and now towards low carbon electric heating systems. Heating transitions are awash with personal, social and cultural complexity but tend to be simplified into grand narratives th
Across the scholarly and journalistic literature, an increasing sense of future uncertainty and prevailing sense of dread is being narrated. This unsettling sense of futurelessness seems to cut across scales in that globally unfolding menaces also shape lived experience locally in specific sites, where global risks intersect with local hazardousness of place. In this chapter, we reflect on how a s
Adipocyte dysfunction is a crucial driver of insulin resistance and type 2 diabetes. We identified EH domain-containing protein 2 (EHD2) as one of the most highly upregulated genes at the early stage of adipose tissue expansion. EHD2 is a dynamin-related ATPase influencing several cellular processes, including membrane recycling, caveolae dynamics and lipid metabolism. Here, we investigated the ro
Environmental exposure to noise and particle matter (PM) are risk factors for cardiovascular disease (CVD). Although there are often higher levels in occupational settings, little is known about noise and particle exposures at work and CVD risks. We investigated occupational noise and particle exposures and acute effects on pulse rate and blood pressure. 46 active, non-smoking, male construction w
Despite their detrimental circumstances, the number of refugee-owned businesses is on the rise—a situation referred to as “the paradox of refugee entrepreneurship.” However, a key question is how refugees, having undergone extreme life disruption due to war, conflict, and forced displacement, fare as entrepreneurs in their host country. Extant studies do not address this question, as they primaril
Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and
Rural gentrification, amenity-led in-migration and displacement in more attractive parts of the countryside are taking up more of the rural discourse. Along this, the centrality of landscape, as a driver for gentrification and as something affected by the same notion, is establishing. This paper explores the paradox of how people move to a certain area because they find that particular landscape a
