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Type 1 diabetes is a serious chronic disease in which the pancreatic islet beta cells are destroyed by autoimmunity specifically directed to intracellular autoantigens. Still undefined environmental factors are likely to initiate the disease process. One of the autoantigens is glutamic acid decarboxylase (GAD65) and attempts are made to induce immunological tolerance against this autoantigen. Alum
By incorporating magnetism into semiconductors, it may possibly be viable to enhance the functionality of materials. An exceptionally important material in this context is GaAs, which can be doped with Mn atoms. (GaMn)As has fascinated research community as a promising candidate for spintronic application. It is quite appealing due to both its compatibility with existing III-V technology and great
Research conducted over the last 50 years has produced discoveries on the importance of glucose control for reducing the risk of diabetic complications, the pathophysiology of type 2 diabetes, the development and validation of mechanistic glucose-lowering targets, and the preclinical and clinical development of individual drugs. This science established the different drug classes that are clinical
Background:There is a lack of data about the information preferences of patients and their partners after a myocardial infarction. Aim:This paper explores anxiety, depression, coping and the desire to be actively involved in care in relation to age, gender and education level in myocardial infarction patients and partners. Methods:One hundred and twenty-eight patients and their partners answered t
Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter to selectively overexpress GPR39 in the beta cells in a double transgenic mouse strain and challeng
Behavioural syndromes, that is correlated behaviours, may be a result from adaptive correlational selection, but in a new environmental setting, the trait correlation might act as an evolutionary constraint. However, knowledge about the quantitative genetic basis of behavioural syndromes, and the stability and evolvability of genetic correlations under different ecological conditions, is limited.
Close collaboration is considered important; but is close collaboration for all purchases necessary to create value-in-production? In construction as well as in other industries, companies purchase a variety of items that require different amounts of attention to the relationship with suppliers. Buyer-supplier relationships are investigated in relation to how they bring value-in-production in the
Nursing homes are a setting in which death and dying is common. How death and dying is articulated and the actions that take place in a nursing home constitute a discourse that guides the staff in their work. The aim of this study was to explore the discourse of death and dying in nursing homes from the perspective and understanding of the staff. The study draws on Foucault’s discourse analysis. D
Putting climate change policy-integration into practice is challenged by problems of institutional misfit,due to, inter alia, deficient vertical administrative interplay. While most focus within the field of climatechange research has targeted the national–local interplay, less is known about the interface of regionaland local perspectives. Here, the aim is to study that interface with a specific
Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-
Pneumococci isolated from the ear exudate in 245 children under 10 years of age afflicted with acute otitis media were typed. Types 3, 6, 14, 18, 19 and 23 were found in 80% of the cases. In the remaining cases, 15 other types were found. Five strains were not typable with the antisera used. Types 14 and 23 were found twice as often in the age group 0-3 years as in the higher age groups, whereas t
