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ABSTRACT Intact insulin signaling and glucose transport in adipocytes are crucial to maintaining whole-body energy metabolism. Focal adhesion kinase stands as a central intracellular protein facilitating signaling between the extracellular matrix and the cytoplasm, thereby regulating cellular metabolism. Here, we have investigated the role of focal adhesion kinase in adipocyte glucose transport us
Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or
Public libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associatiPublic libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associati
Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ
Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstr
The majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifies organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existenceThe majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifes organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existence
Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Models of n
We investigated early electrophysiological responses to spoken English words embedded in neutral sentence frames, using a lexical decision paradigm. As words unfold in time, similar-sounding lexical items compete for recognition within 200 milliseconds after word onset. A small number of studies have previously investigated event-related potentials in this time window in English and French, with r
Vi presenterar skyddsåtgärder som vidtagits som en del av åtgärdsprogrammet ”Projekt Skräntärna” under perioden 2007–2020 i Sveriges största koloni, Stenarna i Björns skärgård, Uppland. En kombination av övervakning, forskning och förvaltningsåtgärder genomfördes enligt en flexibel strategi, där både etablerade och nya tekniker användes. Varje år under häckningssäsongen gjordes fyra besök för att
EU law increasingly requires that the Member States establish independent administrative bodies in various fields. Examples include market supervision, non-discrimination, and data protection. This article addresses the realisation of such requirements in the five Nordic states. The West Nordic systems of Denmark, Iceland, and Norway feature a traditional hierarchic organisation of the administrat
What is the relationship between trust and the quality of political institutions in a society? According to an influential cultural perspective, social trust—the belief that most people can be trusted—is a value inculcated during individuals’ formative years, and remains fixed afterward. A second perspective holds that social trust reflects experiences throughout the life course, particularly inte
In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies suggest mitochondrial ABCB7-type exporters are involved in maturation of cytosolic iron-sulfur proteins. However, the molecular mechanism for how the ABCB7-type exporters participate in this process remains elusive. Here
We present new estimates of the living standards among the rural labouring classes in Sweden from 1750 to 1900. Starting with a database of more than 1,000 probate inventories of rural, landless and semi-landless people from the years 1750, 1800, 1850 and 1900, we study the development for crofters in particular. In a sub-sample of 120 probate inventories we map in great detail the material items
The paper starts from the hypothesis that materialist state theories (particularly Gramsci, Bourdieu and Poulantzas) and sustainable welfare approaches are capable of informing state-led ‘eco-social’ policy strategies that have the potential of overcoming the growth imperative in economy and society. It first outlines some general principles of such state action concerning economy, welfare, enviro
Ionotropic glutamate receptors are ligand-gated ion channels governing neurotransmission in the central nervous system. Three major types of antagonists are known for the AMPA-type receptor GluA2: competitive, non-competitive (i.e. negative allosteric modulators; NAMs) used for treatment of epilepsy, and uncompetitive antagonists. We here report a 4.65 Å resolution X-ray structure of GluA2, reveal
