Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF)

When different polling organisations conduct political party preference polls at different times, different parties might be reported. If the estimated voter shares of these polls are combined into a time series we obtain a compositional time series, but with varying number of parts, thus prohibiting the use of standard compositional time series analysis tools. We discuss the problem and suggest a

Although numerous genes are known to regulate serum lipid traits, identified variants explain only a small proportion of the expected heritability. We intended to identify further genetic variants associated with lipid phenotypes in a self-contained population of Sorbs in Germany. We performed a genome-wide association study (GWAS) on LDL-cholesterol, HDL-cholesterol (HDL-C), and triglyceride (TG)

The incidence of acute appendicitis and the total number of appendectomies performed in the adult population admitted to our medical center are both decreasing. The cause is not clear. Better nutrition and the wide-spread use of antibiotics are two possible factors which come to mind, but we know of no scientific evidence that these are responsible. There has been a slight decrease in the mean die

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Vari

The present facsimile of The Rudiments or Principles of the German flute (1729)—now republished for the first time since 1729—is a separate supplement to the comparativestudy Les Traditions en Mouvement Principes de la Flute Traversiere ou Flute d’Allemagne (1707) by Jacques Hotteterre Le Romain and The Rudiments or Principles of the German flute (1729) the first English translation of Hotteterre’

The SXL (Soft X-ray Laser) project developed a conceptual design for a soft X-ray Free Electron Laser (FEL) in the 1-5 nm wavelength range, driven by the existing MAX IV 3 GeV linac. In this contribution we will focus on the FEL operation modes developed for the first phase of the project based on two different linac modes. The design work was supported by the Knut and Alice Wallenberg foundation

Multiword expressions (MWEs) are common word combinations which exhibit idiosyncrasies in various linguistic levels. For various downstream natural language processing applications and tasks, the identification and discovery of MWEs has been proven to be potentially practical and useful, but still challenging to codify. In this paper we investigate various, relevant to MWE, resources and tools for

This paper further explores the novel concept of the opportunity space, which refers to the limits and possibilities of regional development trajectories and the idea of deliberative agency. Opportunity spaces are formed, perceived and used by individual agents or groups of agents and serve as a bridge between structure and agency. Drawing on six comparative case studies from Finland, Norway and S