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The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with no

Tipping is a social norm in many countries and has important functions as a source of income, with significant social welfare effects. Tipping can also represent a form of lost tax revenue, as service workers and restaurants may not declare all cash tips. These interrelationships remain generally insufficiently understood. This paper presents the results of a comparative survey of resident tipping

The emergence of markets for on-demand online physician consultations —direct-to-consumer telemedicine (DCT) — is currently transforming many healthcare settings. DCT may be a cost-effective substitute for in-person consultations, but the convenience of seeking DCT may increase the demand for the service and consequently also the costs for health insurers. To causally assess the degree to which DC

This study aims to investigate expressive writing in young adolescents, based on the model constructed by J.W. Pennebaker. Qualitative analysis of written essays has been conducted, the main purpose being exploring descriptions of relationships and expressions of emotions. Further-more, the intention has also been to study eventual gender differences and their forms of expressions in the essays. T

Through a series of problem debates and methodological discussions, a model is presented for combining economic methodology with political science approaches to trade analysis. The developed differentiated model is constructed through contemporary theory and statistical methods as well as newly presented theory to the field of IPE. Through the numerical analysis of the DTA model, the export distor

At the moment, democracy enhancing projects can be seen everywhere on the municipal level. The purpose of this thesis is to explain how the city of Lund takes on this challenge, why they have chosen to carry out citizen councils and if these are a good way to intensify democracy and open communication channels between citizens, the administration and the elected officials. The theoretical framewo

According to the theory of elitist democracy civic political participation should be reduced to participation in the democratic elections. This essay examines whether a high rate of institutionalized political participation beyond the elections leads to: (a) that those who are included gets a more favourable treatment at the expense of the common interest, in other words that their self interest t