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Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the

Though new goals for sustainable cities and transport systems have been developed, decisions and planning at a local level often fail to achieve these ambitions. The purpose of this article is to analyse the factors in local decision-making and planning practice that conduce to urban sprawl and increased car traffic. The article analyses how the conscious application of so-called "day-to-day decis

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highligh

Additive Manufacturing (AM) is a technology that, while removing many of the constraints of traditional manufacturing, imposes some new constraints of its own. Because of this, engineers and designers need to be taught a new set of skills in design for additive manufacturing (DfAM) in order to become competent in designing parts that maximize the benefits offered by AM. Around the world, universit

This paper conducts an inductive case study to develop theory on the role of family in the host and home country in the process of immigrant entrepreneurs’ creation of entrepreneurial opportunities. We employ the perspectives of the opportunity creation process and family social capital. We conducted four cases of immigrant entrepreneurs from Lebanon, Syria, Cameroon and Mexico, that launched busi

Migrant integration is a long drawn out process requiring synergies with various dimensions of life, rhyming with those of the host country. In this paper, we attempt to deconstruct the digital narratives of migrant to explore how they may lead to a meaningful assessment of their acculturation and consequent integration in their host societies’. Drawing on acculturation theory as a lens, we argue

The last 20 years have seen a flood of studies of resistance, ranging from collective to individual acts of resistance, from the study of material aspects to its more ideational ones. Yet students of resistance have neglected the psychological dimension of everyday individual acts of resistance to power. This article is a first step to remedy that oversight. Inspired by Butler’s reading of Foucaul

Within the world of professional wrestling, the blurred boundaries of the live event and physical nature of the sport intersect with the dramatized storytelling of this entertainment experience. As such, this chapter considers how audiences and fans interact with professional performers to co-produce the cultural practices of professional wrestling. The author uses ethnographic research at live pr

Constructive alignment is the pedagogical principal which connects learning goals and learning activities with assessment. Learning goals should inform the student about what they’ll know once they finish the course. Learning activities is what the student needs to do to fulfill the goals. The assessment measures to what degree the student reaches the learning goals. The principal of constructive