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Celiac disease is an autoimmune disease characterized by inflammation localized to the small bowel, but less is known about systemic signs of inflammation. The aim was to measure cytokines of the T helper 1 (Th1) and T helper 2 (Th2) cell patterns in children with screening detected celiac disease before and after treatment with a gluten free diet.
To compare physical activity measures and their associations with insulin sensitivity, β-cell function and body mass index (BMI) between Iraqi immigrants and native Swedes.
Celiac disease is associated with tissue transglutaminase autoantibodies (tTGA) in individuals carrying the HLA risk-haplotypes DQA105:01-DQB102:01 (DQ2) and/or DQA103:01-DQB103:02 (DQ8). The aim was to identify celiac disease in a HLA genotyped birth-cohort prospectively screened for celiac disease.
The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. Mitochondrial ATP production by oxidative phosphorylation (OXPHOS) is known to play
Learning from incidents (from minor disturbances to major accidents) is considered one of the most important ways in the process industry to learn from experiences for improving safety performance. Most companies have a formal incident learning system and considerable resources are used for reporting incidents and for utilising these experiences to prevent future incidents. However, there are many
Many passerines migrate during the night and at high altitudes, making their migration difficult to observe. By using tracking radars we have been able to make exact observations of the flight behaviour of passerines on nocturnal migration, which has enabled us to test several hypotheses about adaptive values and constraints regarding migratory behaviour in different ecological contexts. We have i
A decline of suicide rate can be accomplished by different psychiatric interventions. Early identification of individuals at risk for future suicide is especially important. Results from rating scales could add detailed information, which in turn might strengthen a psychiatric suicid risk assessment. This thesis deals with emergency evaluations and psychiatric inpatient evaluations after a suicide
This thesis consists of three self-contained papers that all relate to the understanding of equality. The first chapter investigates the effects of preschool attendance on children in Kenya and Tanzania. We use a within-household estimator and data from nationally representative surveys of school-age children's literacy and numeracy skills, which include retrospective information on preschool atte
Total internal reflection fluorescence (TIRF) microscopy is a powerful method that allows examination of plasma membrane close events in real time. The last decade, the method has successfully been used to explore GLUT4 translocation in adipocytes. Here, we describe the procedure for studying GLUT4 trafficking using TIRF microscopy in isolated primary adipocytes.
Wolcott-Rallison syndrome is a rare genetic syndrome of neonatal diabetes, liver failure, and growth retardation. We present a case with a EIF2AK3 p.(Arg902Ter) mutation, additionally complicated by hypothyroidism, impaired renal function, and exocrine pancreas insufficiency, focusing on clinical management. For its optimization, thorough care of multiple organ systems is needed.
The aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. The thesis was based on five studies, in which we have evaluated biochemical analy
The traditional restrictive attitude towards claim for compensation about non-pecuniary harms in both cause law and legislation become weaker even if the theoretically and practically reason behind the old exception-construction remain. This reason can best be explained by the thesis about incommensurability when it comes to compensate for some losses that money cannot compensate. To explain why t
Aerosol particles are found in the whole troposphere. Research regarding these particles has gained increased attention because of the effect the particles have on both health and climate. In the atmosphere, aerosol particles scatter incoming solar radiation and this has a cooling effect on the Earth’s climate. But there are particles, especially those containing soot, which can absorb sun light a
