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In this thesis we have used cells dissected from the lateral ganglionic eminence (LGE), the medial ganglionic eminence (MGE), and the cortical primordium of the embryonic mouse forebrain. The tissue was dissected from either i) wild-type mice, ii) green fluorescent protein (GFP)-, or iii) Gtv-a-expressing transgenic mice, and subsequently grown and expanded in vitro using two different protocols.

The studies in this doctoral thesis investigated how home literacy, self regulation, academic self-concept, and goal orientation influence reading ability. Study 1 investigated the effect of family-based prerequisites, reading attitude, and self-regulated learning on reading ability. Students (n= 4,018) in the eighth grade answered the IEA reading literacy test and the SRLQ. Structural Equation Mo

Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle

Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. Their expression of genes and proteins that regulate normal sympathetic development and cell cycle/cell death regulators was a

C4b-binding protein (C4BP) is an acute-phase plasma glycoprotein which regulates the complement system through its affinity for C4b. In addition, C4BP binds to the anticoagulant protein S and to serum amyloid P component (SAP). Protein S is a vitamin K-dependent protein which looses its anticoagulant properties when binding to C4BP. C4BP is composed of two types of subunits, the a-chain and the b-

The ABO blood group system is undoubtedly the most important genetic and phenotypic marker in clinical transfusion medicine. The A and B determinants are immunodominant, terminally located carbohydrate residues of glycoconjugates on erythrocytes and other cell surfaces. The enzymes responsible for assembly of these structures are glycosyltransferases encoded by the ABO genes on chromosome nine. T

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The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding

This dissertation contains seven studies exploring novel instrumentation for ion and electron spectroscopy, including their applicability at storage ring light sources. The studies focus on instrumentation to study decay, dynamics and dissociation of photoexcited molecules, and the possibility to host such instruments at MAX~IV. Commissioning of an instrument for negative-ion/positive-ion coincid

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Malignant hyperthermia (MH) susceptibility is a rare inherited muscular disorder, which may cause a lethal increase in metabolism during anaesthesia with certain commonly used anaesthetic. Susceptible individuals are without any signs or symptoms. It is important to identify individuals at risk, since the MH reaction is preventable. Susceptibility to MH is diagnosed with an in vitro contracture te

A building-integrated multifunctional PV/T collector have been developed and evaluated. The PV/T solar window is constructed of PV cells laminated on solar absorbers and is placed in a window behind the glazing. To reduce the costs of the solar electricity, reflectors have been introduced in the construction to focus radiation onto the solar cells. The tiltable reflectors render a possibility to c

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This thesis focuses on the pedagogue as a social being and how she or he experiences the social life in preschools and schools in Tallsten. In 1996, the child-care and education authorities in Tallsten introduced a new manner of thinking and working based on the communicative pedagogy. The idea of communicative pedagogy was origanlly put forth by the Danish teacher Lars Rokkjaer. One of the goals

Optimal foraging and prey preference in top predators may affect population and community dynamics and structure. Also, optimal foraging and prey preference may shift with prevailing conditions, and therefore create changes in the effect of predation. In this thesis, I examine the effects of intraspecific interactions among northern pike on pike predatory behaviour, prey preference, and subsequent