Sökresultat

Filtyp

Din sökning på "swedish" gav 92283 sökträffar

Body Protein and its Change in Patients During Anti-Tumor Treatment

The purpose of this study was to investigate how total body protein and its fraction of body weight (body protein fraction) change in cancer patients during different anti-tumor treatments, and to see if these changes have any clinical significance in the form of prognostic value or correlation with disease course and tumor response. In 84 patients, 28 with lung cancer, 24 with gastrointestinal t

Arkitekturens kroppslighet. Staden som terräng

Beginning with the notion that spatial and material qualities of architecture set limits and create conditions for how we make use of it, the overall aim and ambition of this thesis is to develop this notion and to contribute to a deeper understanding of the relationships that are produced between the materiality of architecture and a bodily appropriation of it. To investigate this the thesis esta

The telomere binding proteins in yeast and their role in telomere maintenance

Telomeres are the end-structures of linear chromosome which are crucial for maintaining genome integrity. The telomeres prevent the DNA-repair machinery from recognizing the chromosome ends as double-strand breaks and from end-to-end fusions. The telomeres are composed by short repetitive units of TG-rich DNA and associated specialized telomere-binding proteins. Due to that replication only can

Vasodilator actions of EDHF and anandamide

Vasodilator responses to endothelium-derived hyperpolarizing factor (EDHF) and anandamide in isolated arteries were investigated. A combination of the potassium channel blockers charybdotoxin and apamin inhibits EDHF-mediated relaxations. Experiments in which charybdotoxin or apamin was substituted with other potassium channel inhibitors indicated that small- and intermediate-conductance calcium-a

Respiratory Sinus Arrhythmia and Emotion : Effects of pictorial stimuli and state anxiety

Respiratory sinus arrhythmia (RSA) refers to heart rate variations due to respiration, which results from parasympathetic nervous system activity mediated via the tenth cranial nerve, the vagus. Thus, the magnitude of RSA is considered as an index of cardiac vagal tone. This thesis explored RSA during emotional responding in healthy women and men. In the first two studies fear-relevant pictorial s

Synergistic interactions involving amphiphilic polymers in solution

The properties of hydrophobically modified cellulose derivatives in aqueous mixtures with various other molecules have been investigated. Mixtures of a hydrophobically modified polymer and alkali-sensitive, degradable surfactants gave rise to time-dependent viscosities. With time, the viscosity decreased continuously or went through a maximum, depending on the initial surfactant concentration. Th

On lumbar spine stabilization

71 consecutive posterolateral lumbar fusions without decompression or internal fixation were evaluated with a mean follow-up time of 3.5 (2-7) years. The diagnoses were spondylolysis-olisthesis in 43 cases, degenerative disc disease and/or facet joint arthrosis in 16 cases and pain post laminectomy/ decompression in 12 cases. 54/70 patients had a solid fusion. In the group with spondylolysis-olist

Retinal Transplants: Growth Differentiation Integration Organization and Survival

The goal of the study was to get a better understanding of factors controlling the growth, differen-tia-tion, integration, organization and survival of retinal transplants, with the long-term view of eventually developing retinal transplantation into a clinically useful procedure for treating degenerative retinal disorders such as retinitis pigmentosa. Embryonic day 15 rabbit retinas were transpl

ß2 integrin-induced signal transduction events in human neutrophils

Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. PMN are highly mobile cells that possess regulated mechanisms for controlling the expression and activation of adhe

Improving Parton Showers with Fixed Order Matrix Elements

This thesis considers numerical simulations of high energy particle collisions, and improvements in the description of multiple collimated jets of hadrons in collision events in particular. In the event simulation software called event generators, the structure of multi-jet events is determined through an interplay of the input calculation, parton showers and phenomenological hadronisation models.

Bioprocess Monitoring and Control in Pseudomonas cepacia and recombinant Escherichia coli cultivations

The control of cultivation conditions and its influence on growth and production have been investigated. The use of fed-batch processes have been demonstrated for several cultivation systems and so has the use of different control signals in these systems. Fed-batch cultivation of Pseudomonas cepacia with on-line measurement and control of the growth rate limiting (toxic) substrate, sodium-salicy

Evolution and Ecology of AhR genes in Atlantic salmon (Salmo salar L.)

In vertebrates, studies of the aryl hydrocarbon receptor (AhR) have been of particular interest due to its direct involvement in the toxic effects exerted by several environmental pollutants, such as PCB and dioxin. After binding to the toxic molecule, this receptor initiates transcription of several genes that are part of the biotransformation battery but most notably the cytochrome P450 (CYP) ge

Effects of Total Parenteral Nutrition on the Exocrine and Endocrine Pancreas. An Experimental Study

During total parenteral nutrition (TPN) adequate nutrition is provided intravenously and the enteral route is bypassed. The integrity of the gastrointestinal (GI) tract, however, is dependent on the passage of food through it. This thesis deals with the effects of TPN on the pancreas and the parotid glands. TPN induced hypotrophy of the exocrine pancreas and the parotid glands. The amylase concent

How can p53 induce differentiation of leukemic cells?

The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. The tumour suppressor protein p53 is a transcription factor, and can induce cell cycle arrest and apoptosis of maligna

Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis

The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a

A Concept from Sensor to Sustainability in Machining - An Interdisciplinary Approach over a Wide TRL Range

This publication describes a concept that intends to enable an optimization of machining with regard to the balance between criteria related to technology, economy and sustainability. The work is of a discussion nature and intends to provide a framework for further research and development in the area. Previous research and development during the 80's and 90's is presented in general terms and in

Ventifacts and wind deflation surfaces in context with glaciofluvial sediment successions in southern Sweden – their age and implication for glacial history

Recent suggestions propose that the glacial landscape in southern Sweden is primarily a relict from the Saalian glaciation (>130 ka). The arguments for this standpoint are the assertion that the majority of glaciofluvial deposits in this region are till-covered, and that wind-abraded clasts are observed at the contact between glaciofluvial sediments and till at numerous locations. Furthermore, it

Event Detection in Eye-Tracking Data for Use in Applications with Dynamic Stimuli

This doctoral thesis has signal processing of eye-tracking data as its main theme. An eye-tracker is a tool used for estimation of the point where one is looking. Automatic algorithms for classification of different types of eye movements, so called events, form the basis for relating the eye-tracking data to cognitive processes during, e.g., reading a text or watching a movie. The problems with t