An essential part of the development of new radiopharmaceuticals for use in diagnostic nuclear medicine is the determination of its biokinetic properties. The uptake and turn-over of the radiopharmaceutical in the source organs is of great interest since this could determine whether the radiopharmaceutical would be suitable for clinical use or not. It is also important that the biokinetics and dos

The influence of added colloidal particles on the phase behaviour of a polymer solution was investigated. Binary, quasi-binary and mixed polymer solutions were used in the study, where at least one of the polymers had an affinity for the surfaces of the colloidal particles. Experimentally, silica and polystyrene latex particles were used as colloidal particles. Theoretical calculations have been p

The aim of the thesis is to investigate experiences of and ways of relating to environmental issues and towards their profession among a group of graduates in environmentla science. The respondents were either in the end of or had completed an educational program in Environmental sciences with a social science perspective offered at Malmö University. Those who hade completed the program have recen

The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered do

The kidneys play a pivotal role in the adaptive physiology of the pregnant woman, presenting some changes at term similar to the changes found in preeclampsia – a state of increased risk of fetal and maternal morbidity and mortality. The aim of these investigations was to explore possible similarities in blood pressure regulation, renal function and structure in normal term and preeclamptic pregna

Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zym

According to the theory of sexual selection, traits can evolve because they confer a mating advantage in competition with members from the same sex. In animals, sexual selection is considered as an important evolutionary force. In this thesis I have investigated the potential for sexual selection in plants. I have concentrated on the phase of reproduction that occurs after pollinators have deposit

In this thesis, semiconductor nanowires are studied from the point of view of growth and electrical properties. The growth of nanowires is done by chemical beam epitaxy (CBE), an ultra-high vacuum technique allowing a precise control of precursor deposition and low growth rates. In conventional epitaxy, growth is usually two or three- dimensional, depending on growth conditions and material combin

This thesis deals with the problem of interpreting test scores. The intention has been to explore and elucidate the effects of trait anxiety on test scores that have been obtained in applied research settings. Paper I showed that different relationships between personality traits and cognitive functioning emerged in a group of men with solvent induced chronic toxic encephalopathy (TE; N=57) compa

Nanowires constitute one of the fundamental building blocks in assembled nanodevices. Due to the high surface to volume ratio, the fraction of surface atoms is not negligible for nanosized elements. Because of the reduced coordination of surface atoms, the physical properties deviate from those of the bulk, which influences the overall physical properties of nanostructures. Consequently, this prov

This thesis focuses on the magnetotransport properties of highly Mn-doped crystalline GaAs nanowires. The GaAs nanowires were first grown by metal-organic vapor phase epitaxy from gold seed particles, and subsequently implanted with Mn ions under varying conditions, e.g., ion fluence and acceleration voltage. The implantation process was carefully analyzed and optimized within the research project

This doctoral thesis is in the field of biomedical signal processing with focus on methods for the analysis of atrial fibrillation (AF). Paper I of the present thesis addresses the challenge of extracting spatial properties of AF from body surface signals. Different parameters are extracted to estimate the preferred direction of atrial activation and the complexity of the atrial activation pattern

Preservatives are biologically active substances which are required in water-based products/systems to prevent growth of micro-organisms. Kathon® CG (K-CG), one of several preservatives based on 5-chloro-2-methyl-4-isothiazolinon-3-one (MCI) and 2-methyl-4-isothiazolin-3-one (MI) has been shown to be a common sensitizer in dermatitis patients. The aims of the study were to find a method to demons

This thesis describes patients in acute postoperative pain as well as patients with acute cancer-related pain in palliative care, and their experiences and perceptions of pain management in relation to HRQOL and the multidimensionality of pain. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and questionnaires; APS, SF:36 and a new developed q

The main objective of the research presented was to gain an understanding of how the dynamics between professionals, tools and objectives work in an operating unit in order to obtain knowledge useful when designing the operating unit of the future with emphasis on the work environment, effectiveness and patient safety. By investigating how different professions in the operating theatre view their

This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. Both factors were found to be important for the virulence of the strain and contributed in an additive manner. The mouse model mimicked cert

The aim of the thesis was to examine the expression and function of the extracellular nucleotide P2 receptors in the cardiovascular system. In the cardiovascular system nucleotides are released during shear stress, hypoxia, ischemia, from endothelial cells, smooth muscle cells, aggregating platelets, inflammatory cells and erythrocytes. We demonstrate that ATP, ADP, UTP and UDP induce vascular rel

To examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). Vital stat

Algorithms based on the variational approach, as used in statistical physics, are developed. For constraint satisfaction problems a novel cost function, based on information-theoretic arguments, is introduced, and an algorithm similar to the mean-field annealing algorithm is proposed. It outperforms the conventional mean-field algorithm, and its performance is comparable to good problem-dedicated

Maternal diabetes mellitus (DM) during pregnancy has detrimental health impacts on both the mother and fetus, and include increased risks of cardiac malformations, cesarean section (CS), and asphyxia. The aim of the thesis was to investigate short and long term cardiac effects after fetal exposure to DM, investigate the ability of a 5 minute Apgar score as a marker for obstetrical care, investigat