Stroke is a major cause of death and disability around the world. Stroke leads to loss of neurons and also other cells in the brain due to lack of blood supply. Currently no therapies are available to treat stroke-related disability. It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. This increased neurogenesis is not sufficient to restore lost f

This thesis focuses on developing stem cell targeted gene therapy for the severe hereditary disorder Infantile Malignant Osteopetrosis (IMO) as well as increasing the understanding of how the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a rare congenital disorder associated with an increased number of non-functional osteoclasts and the a

In radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. Lutetium-177 (177Lu) is a beta-particle-emitting radionuclide (t½=6.7 days) and astatine-211 (211At)

Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is

Decisions in the treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last ten years, cancer research has seen a gradual transition towards personalized medicine, i.e. the exploi

The construction sector is responsible for around 40 % of all generated waste in Sweden and is also responsible for around 21-22 % of all carbon emissions. In a sector that is responsible for a substantial part of Sweden’s climate footprint, it’s important to find solutions to the negative effects towards the climate. Much of the generated waste comes from building and demolition waste which ends

Meniscus tears are common after knee injuries. The current treatment in patients under the age of 40 is typically arthroscopic partial meniscectomy (APM) or arthroscopic meniscus repair. Meniscus tears and surgeries are associated with an accelerated progression to knee osteoarthritis (OA) and disability. PAPER I is an observational cohort study, utilising the Skåne Healthcare Register (SHR) to id

In obesity and several other disease scenarios, the measurement of fat accumulation in various organs and tissues has become a sought-after technique in clinical diagnostics and research. Especially, quantitative and non-invasive techniques which also provide images of accumulated fat throughout the body would be valuable. In the typical hospital, magnetic resonance imaging (MRI) is the only techn

Silicon (Si) is ubiqutious in natural waters as dissolved silica (DSi) and is used as a nutrient by many plant and animal species. DSi ultimately derives from the weathering of silicate minerals, a process which also consumes atmospheric CO2 and couples the silicon and carbon cycles. These processes, among others, impart observable fractionations to the stable isotopes of silicon, which makes the

In the event of a radiation accident, it is crucial to make rapid estimates of the absorbed dose received by both emergency workers, so-called first responders, and members of the public. Today, only personnel in rescue teams responding to nuclear emergencies have access to individual dosemeters. To make accurate assessments of the radiological consequences of an emergency situation, methods of re

The aim of this thesis was to investigate whether a structured and systematic approach on improving pharmacotherapy in the elderly (the LIMM-model) would lead to a more appropriate and accurate drug use in the elderly. The elderly use many drugs and are more prone to suffer from adverse drug reaction. It is therefore important to address the quality of their drug therapy. The first study presente

There were two principal objectives for this thesis. The first was to develop a methodology and evaluation model of moisture redistribution in order to make the future relative humidity in a screeded concrete slab predictable. The second objective was to develop a method to determine the critical humidity for ion transport in concrete. Residual moisture in screeded concrete slabs may be redistrib

All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. However, an alternative model has already been

Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. Pharmacological agents to glutamate receptors at this synapse, (of which some are already clinically tested), could preve

The aim of this thesis was to investigate the effects of cortical reorganisational changes following experimental deafferentation and peripheral nerve injury and apply the concept of brain plasticity to enhance sensory re-education following peripheral nerve injury and repair in the hand. In the first two papers the effects on hand function of contralateral deafferentation was investigated. Tourn

Stroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. Aged and young adult rats were subjected to stroke by transient occlusion of the middle cerebral artery and proliferating cells were labeled by intraperitoneal administ

Sammanfattning Avregleringen av den finansiella marknaden har skapat förutsättningar för alternativa marknadsplatser. Företag kan i dag välja att notera sig på icke traditionella börser som inte är knutna till en fysisk handelsplats. För att skapa förtroende och långsiktighet för dessa virtuella marknadsplatser krävs det att vikt läggs vid relationen till kunderna. En del i detta är att ta hänsyn

Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. Following an MI it is important to accurately determine the size of the infarction, as it can be used for guidance in terms of

Seawater desalination constitutes an important water supply to the population bordering the Arabian Gulf, the Mediterranean Sea and the Red Sea. The three regions represent about 11.8% of the world land area and the countrieshosted approximately 9% of the world population in 1950 and 2008 and are also projected to do so in 2050. The results obtained for desalination capacity in the study area were

The treatment for head and neck squamous cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour stage with neck metastases at the time of diagnosis. The treatment protocol previously comprised rad