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Background: Acquired loss of the largest von Willebrand factor multimers is a common hemostatic disturbance in patients with aortic valve stenosis (AS), resulting in impaired platelet adhesion and increased bleeding risk. AS is also associated with atherosclerosis and myocardial infarction (MI). Our aim was to study the clinical outcomes associated with AS in MI patients treated with dual antiplat

Background Safety data on cancer risks following tumour necrosis factor a inhibitors (TNFi) in patients with spondyloarthritis (SpA) (here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce. Our objective was to assess risks for cancer overall and for common subtypes in patients with SpA treated with TNFi compared with TNFi-n

BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.AIM: A model was developed to comp

EPA (entrustable professional activities) avser aktiviteter som ingår i en läkares dagliga arbete och som läkaren ska klara med en definierad grad av självständighet första dagen som legitimerad läkare.En modell för att träna och bedöma sådana aktiviteter kan säkerställa att studenter klarar av det faktiska arbete som ska utföras första dagen efter legitimation, och den tydliggör också progressionEntrustable Professional Activities (EPAs) define observable key tasks that a doctor should be able to do independently after having completed a certain level of education. Progression is facilitated by frequent assessments of the defined activities, with increased degree of independence. The observations should be supported by constructive feed-forward. EPA is currently used in several countries

Japan is well-renowned in the international community for its expertise in high-capacity, punctual railway operations. Particularly the high-speed trains, the Shinkansen, are very well known and respected internationally, but the knowledge outside Japan is more limited regarding more conventional lines, commuter trains, and the metro. Despite this, during rush hours trains in the Tokyo area can be

The transition to a resource efficient economy that makes effective use of raw materials and energy is a multi-level dynamic process requiring a wide systems perspective. To operationalize this transition in a holistic manner, the concept of Circular Economy (CE) has been championed by major economies around the world. The idea with CE is to strive towards maximizing the utilization of products, c

Corporate growth is often viewed as being either internally generated or externally achieved through mergers and acquisitions (M&As). During the last decade, strategic alliances have become an increasingly popular third alternative to either internal or acquired growth. Alliances can be cheaper, more flexible, and faster than internal or M&A growth. However, they suffer from a major drawba

Weathering rates of base cations are crucial in critical load calculations and assessments of sustainable forestry. The weathering rate on a single site with detailed geological data can be modelled using the PROFILE model. For environmental assessments on a regional scale, the weathering rates for sites are scaled into regional maps. The step from sites to regional level requires focus on the spa

BACKGROUND: The CHADS(2) score (C, congestive heart failure [CHF]; H, hypertension [HT]; A, age ≥75 y; D, diabetes mellitus; S(2) , prior stroke or transient ischemic attack) is used to assess the risk of ischemic stroke in patients with atrial fibrillation (AF). However, its role in patients without documented AF is not well explored. HYPOTHESIS: The goal of the current study was to explore if th

Background: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of afor

Background: In a previous cohort study of 4-year-old Danish children, revaccination with the live measles-mumps-rubella vaccine (MMR) was associated with a 16% reduction in the rate of hospitalization lasting two days or longer for non-measles-mumps-rubella infections. Aim: To examine if the introduction of revaccination with MMR at 4 years of age in Denmark (spring 2008) and at 7–9 years of age i

De riktade ränteavdragsbegränsningsreglerna trädde i kraft år 2009, och har sedan dess ändrats vid två tillfällen. Syftet med reglerna är att förebygga skatteplanering inom en intressegemenskap genom ränteavdrag. Huvudregeln återfinns i 24 kap. 18 § första stycket inkomstskattelagen, vilken föreskriver att ränteutgifter avseende en skuld till ett företag i intressegemenskapen endast får dras av un