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In logistics, transport purchasers are increasingly facing environmental challenges. The role of logistics managers is important because their decisions as to how and where resources are used can potentially have major impacts on the environment. The challenge for logistics managers is to determine how to incorporate environmental management principles into their daily decision-making processes. 1

Vasodilator responses to endothelium-derived hyperpolarizing factor (EDHF) and anandamide in isolated arteries were investigated. A combination of the potassium channel blockers charybdotoxin and apamin inhibits EDHF-mediated relaxations. Experiments in which charybdotoxin or apamin was substituted with other potassium channel inhibitors indicated that small- and intermediate-conductance calcium-a

Respiratory sinus arrhythmia (RSA) refers to heart rate variations due to respiration, which results from parasympathetic nervous system activity mediated via the tenth cranial nerve, the vagus. Thus, the magnitude of RSA is considered as an index of cardiac vagal tone. This thesis explored RSA during emotional responding in healthy women and men. In the first two studies fear-relevant pictorial s

The purpose of this study was to investigate how total body protein and its fraction of body weight (body protein fraction) change in cancer patients during different anti-tumor treatments, and to see if these changes have any clinical significance in the form of prognostic value or correlation with disease course and tumor response. In 84 patients, 28 with lung cancer, 24 with gastrointestinal t

Beginning with the notion that spatial and material qualities of architecture set limits and create conditions for how we make use of it, the overall aim and ambition of this thesis is to develop this notion and to contribute to a deeper understanding of the relationships that are produced between the materiality of architecture and a bodily appropriation of it. To investigate this the thesis esta

Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. A role for WT1 in hematopoiesis was suggested based on the fact

Aquaporins constitute a class of membrane proteins that create pores through the lipid bilayer of biological membranes, facilitating the passage of water and other small solutes. Nearly all living organisms possess a more or less intricate set up of aquaporin proteins and the importance of these channels has been implicated in many aspects of health and disease. The aim of the projects summarized

Antibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. In order to evolve the technology from small dedi

Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f

Abstract. This thesis describes factors that are rate limiting for the folding of two small proteins, U1A and CI2 which fold without accumulating intermediates. The [GdnHCl] dependencies of the unfolding- and refolding kinetics of U1A display downward curvatures. However, as the curvatures are precisely matched and no indications of formation of partially structured intermediates are seen, the fol

Membrane proteins are particularly important to characterize, since they are involved in cellular processes of utmost importance in control and regulation of cells, such as transport across membranes, signal transduction and photosynthesis. The word "proteome" means all proteins expressed by a e.g. a cell or a tissue, at a certain time point and "proteomics" is the large scale study of these prote

Proteoglycans (PGs) is a class of highly anionic macromolecules that consist of one or more linear polysaccharide chains (glycosaminoglycans, GAGs) covalently attached to a core protein. The biological functions of PGs are mainly due to the interactions of GAG chains with various protein ligands and regulatory factors, such as cytokines and growth factors. PGs and GAGs are critical for a diverse s

Mucosal infections trigger an inflammatory response that includes the secretion of cytokines and the recruitment of neutrophils to the infected site. This thesis describes studies examining the molecular mechanisms of neutrophil migration to sites of mucosal bacterial infection. Escherichia coli (E. coli) infection of epithelial cell layers stimulates chemokine secretion and chemokine receptor ex

The aim of this thesis work was to study phase diagrams, microstructure and phase separation in alkylglucoside systems. Both alkyl glucoside/water systems and microemulsions with alkyl glucosides have been studied. The phase diagram of the ternary n -nonyl-beta-glucoside (C₉G₁)/ n -decyl-beta-glucoside (C₁₀G₁)/water system has been determined and is dis

In the studies of this thesis, a method for automated classification of myocardial perfusion images was successfully developed and evaluated. The results show that the method, based on artificial neural networks, was equally good, or even better than human experts. It was also found that physicians interpreting myocardial perfusion images benefit from the advice of the artificial neural networks.

TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. The release of soluble TNF-receptors was measured with ELISA. TNF binding cap

An introduction into the theory and experimental background of particle physics and the ATLAS detector is given. The transition radiation tracker (TRT) which is vital to the particle tracking and identification is then described giving particular creedence to the calibration. The automation of this calibration is explained. The second half of this thesis and the central part dwells on the analyses

The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t