Filtyp
Posterior laryngitis (PL) is defined as an inflammation involving the posterior part of the glottal region in conjunction with symptoms. The cause is multifactorial. The aims of the work presented in this thesis were to examine symptoms, physical signs, different aetiologies and health-related quality of life (HRQOL) in patients with PL and/or oesophageal dysmotility. In paper I, a group of pati
Seminal plasma is semen without the spermatozoa. Human seminal plasma is a complex mixture of secretions from the sex accessory glands, mainly the seminal vesicles and the prostate. Seminal plasma has high protein content and it also contains ions, sugars and low molecular weight components. Immediately after ejaculation the semenogelins and fibronectin aggregate and a coagulum forms trapping the
Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. This thesis is focused on the leucine-rich repeat proteoglycans fibromodulin
The life-threatening disease of malignant melanoma is one of the fastest growing forms of cancer, affecting an estimated number of 200,000 patients worldwide every year. Although highly curable if detected early, once the melanoma has metastasized there are few treatment options and a median survival rate of only 6-9 months. Consequently, there is an imperative need to identify the factors that dr
This thesis is motivated by an increasing degree of unfamiliarity and prominence of national dimensions in multinational crisis management. The research rationale rests on the argument that trust is important but may erode when roles conflict, which in turn may result when stakeholder interests diverge. The thesis describes trust and national perspectives in terms of role conflict in an EU Operati
Bleeding complications range from 0.5 to 1.6% in connection with central venous catheter insertions but are more frequent in patients with bone marrow failure and severe thrombocytopenia. Although supportive evidence is scarce, prophylactic platelet transfusion is sometimes performed in these patients before catheter insertion. Furthermore, the ideal threshold platelet count and timing of transfus
Neutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan
Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. The 5-year survival rate for patients with limited disease is around 20% while it is
Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote
Association to specific host tissue structures allows pathogenic bacteria to establish an infection and facilitates the spread within its host. Interactions between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is al
Control of the upright stance and locomotion is a complicated process of muscular activity. The muscular activity is dependant on afferent information from the different sensory organs and interpretation in the central nervous system. Age-related degenerative changes exist in all the domains concerned with control of posture. The aims of the studies were to investigate if suspected age-related de
Muntlig bevisning har länge medfört problem i den svenska hovrätten. När ett mål når den andra instansen har kvaliteten på muntlig bevisning blivit sämre, inte minst på grund av att minnesbilder hos förhörspersoner försvagas med tiden. Trots det har utgångspunkten, allt sedan det muntliga och omedelbara förfarandet introducerades genom 1948 års rättegångsbalk (RB), varit att principen om det bästa
Föreställ er att vi i Sverige skulle legalisera det egna bruket av narkotika. Det skulle bli lagligt att snorta kokain, att skjuta upp heroin eller att röka marijuana. Vad skulle detta innebära för svensk Polis, sett ur ett tvångsmedelsperspektiv? Toleransen i Sverige gentemot droger är väldigt låg. Narkotikafrågan har under en längre tid varit, och är fortfarande, högprioriterad hos regering och
Boilerplate är en term som används för att beskriva standardiserade klausuler som ofta återfinns i slutet av ett avtal och som behandlar generella frågor som inte är beroende av avtalets art eller omfattning. Det finns flertalet olika boilerplate, varav en är integrationsklausulen. Klausulen har i och med internationaliseringen av den kommersiella rätten blivit mycket vanligt förekommande i svensk
Due to various reasons like globalization and conflicts many countries are experiencing high levels of in-and outmigration. Strongly increased diversified migration has evoked a multiple reactions from the receiving societies. On the one hand, civil societies may respond positively and openly towards immigrants, but on the other hand, there have been significant changes in public and political att
Häktning är det mest ingripande av våra personella tvångsmedel. Oskyldig eller inte följer det av svensk lag att varje intagen ska behandlas med respekt för sitt människovärde. Vidare ska verkställigheten av häktningen utformas så att negativa följder motverkas, med sådana följder avses bland annat psykiska, sociala och ekonomiska konsekvenser som kan följa av ett frihetsberövande. Om det finns riPre trial detention is a coercion measure where a suspect is incarcerated between the time he or she is being arrested until the trial. A pre trial detainee is considered innocent until proven guilty and thus it is important that the detention is not used as a punishment or rehabilitation. Whether a detainee is innocent or not he or she should be treated with respect for his or her human dignity.
