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HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. Compartmentalized HIV-1 infection of the central nervous system (CNS) m

The aim of the current work was at development and validation of modeling tools for simulation of pulverised wood flames in furnaces and study how different factors influence on such flames. The numerical model involves different sub-models for the physo-chemical processes, such as, two-phase flow motion, drying, devolatilization and shrinkage of particles, the formation and oxidation of volatile,

The intention of this thesis was to investigate autoimmune markers for type 1 diabetes, together with signs of enterovirus infections during the pre- and perinatal period of life, and their possible association with the development of diabetes during childhood, adolescence, and young adulthood. We found that: 1. Newborns with ABO immunization, linked in epidemiological studies with heightened diab

New neurons are spontaneously generated in two regions of the adult brain, the hippocampus and the subventricular zone/olfactory bulb. The objective of this thesis was to study potential implications for adult neurogenesis in Alzheimer's (AD) and Parkinson's diseases (PD). PD is characterized by degeneration of dopaminergic neurons in the substantia nigra. It has been suggested that new dopaminer

The main purpose of this study is to highlight the counselling interview in connection with the choice of upper secondary school from three perspectives, the student's, the counsellor's and society's. The intention is to describe and analyse the counselling interview in the ninth grade with relation to: · the student's expectations, perceptions and values before and after the interviews, · the co

Post-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone

The ability to obtain correct balance control information and adjust motor performance appropriately are essential elements in effective postural control. However, functional disorders may affect the reliability of receptor information and ability to carry out corrective motions needed to maintain balance. This emphasizes the importance of rapid and accurate adaptation processes that can optimize

The aim was to investigate collaboration between relatives of frail elderly patients and nurses in acute hospital wards, and to develop and test an instrument to investigate, from the relatives? perspective, dimensions of collaboration in this context and the association between collaboration and satisfaction with the hospital care trajectory. The underpinning assumption for the study was that rel

This thesis focuses on the healing and remodeling of the morselized and impacted bone allograft, commonly used in revision of loosened hip prostheses with osteolysis. The influence on remodeling by the impaction procedure per se was analyzed, as well as the effects of endogenous bone graft proteins, and an exogenously applied growth factor (OP-1). A bone chamber model in rats was used, with the in

Today’s children live in a world where music in all its different forms has become a significant factor in their everyday life. From earlier research we know that young children are able to create music by singing and using musical instruments. The present study was undertaken with eight-year-old children in school year 2 in order to investigate the children’s composing and composition processes u

The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using a cDNA microarray analysis, I identified TRIM22/Staf50 as a novel direct target gene to p53. The fun

Studies in process control automation show that manual control skills are important in handling situations where the automatic control system fails. The fact that these skills are particularly difficult to maintain and develop in automated production environments is usually described as one of the ironies of automation. This work explores new roles for computer support in developing and maintainin

It is generally recognized that the EU accession process has profound effects on state transformation in the postcommunist applicant countries. A key problem of postcommunism has been a weak ability to implement public policy. This study explores how efforts to fulfill EU conditionality may influence implementing capacity. Firstly, it advances a theoretical framework for this purpose, focusing on

This dissertation makes up the first report based on data collected during the project "Teenagers: aspects of their life style and attitudes" (Tonåringens livssituation och livstolkning) in the subject Religious Studies taken by pupils attending Year 9 during the 1993/94 school year. The general aim of the study is to discover the central values of life which pupils hold, as expressed in an essay