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In this work, hydroxyl- and amino-substituted bridged bicyclic compounds based on bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane and bicyclo[3.3.1]nonane were synthesized and investigated for use in asymmetric catalysis. An improved process for the preparation of an optically active key intermediate for the synthesis of bicyclo[2.2.2]octane-derivatives, using genetically engineered yeast, was devel
