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The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflam
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor immunity in pre-clinical cancer models. We found that T regulatory (Treg) cells infiltrating human or murine tumors expressed high amounts of 4-1BB.
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
Gene panel sequencing has become a common diagnostic tool for detecting somatically acquired mutations in myeloid neoplasms. However, many panels have restricted content, provide insufficient sensitivity levels, or lack clinically validated workflows. We here describe the development and validation of the Genomic Medicine Sweden myeloid gene panel (GMS-MGP), a capture-based 191 gene panel includin
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat
Objective: To describe the clinical and ultrasound characteristics at the time of diagnosis of primary ovarian immature teratoma with no other germ cell tumor components described on histopathology. Methods: This was a retrospective study of women with a histological diagnosis of primary ovarian immature teratoma who had undergone a preoperative ultrasound examination between 1998 and 2024. Cases
Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (I
Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application an
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines ar
Microsoft Word - sjostrom_stefan_thesis.doc Forestry Certification: Why it is not leading to sustainable forest management By Stefan Sjöström November, 2003 A thesis submitted in fulfillment of the requirements of the Degree of Master of Science LUMES, Lund University, Sweden Stefan Sjöström Supervisor: Trollebergsvägen 22A Professor Bengt Nihlgård 222 29 Lund Department of Ecology Sweden Sölvegat
https://www.lumes.lu.se/sites/lumes.lu.se/files/sjostrom_stefan.pdf - 2026-10-09
The intersection of theory and practice: Do crisis communication practitioners apply theoretical guidelines and what (or who) might be stopping them? Abstract Twenty-five in-depth interviews with European crisis communication practitioners were conducted in order to examine the gap between crisis communication theory and practice. Over the years crisis communication has grown to be an important re
https://www.isk.lu.se/sites/isk.lu.se/files/claeys_opgenhaffen.pdf - 2026-10-09
untitled on May 31, 2018http://rstb.royalsocietypublishing.org/Downloaded from rstb.royalsocietypublishing.org Review Cite this article: Hagbard L, Cameron K, August P, Penton C, Parmar M, Hay DC, Kallur T. 2018 Developing defined substrates for stem cell culture and differentiation. Phil. Trans. R. Soc. B 373: 20170230. http://dx.doi.org/10.1098/rstb.2017.0230 Accepted: 27 March 2018 One contribu
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/hagbard.pdf - 2026-10-09
Utbildningsplan Kompletterande pedagogisk utbildning Humanistiska och teologiska fakulteterna LAKPE, Kompletterande pedagogisk utbildning, 90 högskolepoäng Supplementary Teacher Education, 90 credits Program med akademiska förkunskapskrav och med slutlig examen på avancerad nivå / Second cycle degree programme requiring previous university study Beslutsuppgifter Utbildningsplanen är fastställd av
https://www.uvet.lu.se/fileadmin/user_upload/uvet/lararutbildning/Utbildningsplan_foer_KPU_LAKPE.pdf - 2026-10-08
STIPENDIEFONDEN I TORONTO 1 TORONTO A MINORITY REPORT Daniel Olemyr Pälle Kamali 2018-06-25 STIPENDIEFONDEN I TORONTO 2 ANSÖKAN TILL STIPENDIET OCH SYFTET MED RESAN Sverige och i huvudsak storstadsregionerna präglas av en otrolig mångfald. Kulturellt, socialt och erfarenhetsmässigt. Det är omöjligt att säga att människor som bor och verkar i Sverige är på det ena eller andra sättet, tycker det ena
Microsoft Word - 20110211 Avancerad nivå - Regler och rekommendationer för examensarbeten Nfak BESLUT Dnr N 2011/130 1 Naturvetenskapl iga faku l te ten Utb i ldn ingsnämnden Regler och rekommendationer för examensarbeten på avancerad nivå vid naturvetenskapliga fakulteten fr.o.m. 2008-09-15. I detta dokument ges fakultetens regler och rekommendationer för examensarbeten på avancerad nivå, enligt
Webinar highlights: Covid-19 & Human Rights– Vulnerabilities and Inequality - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice
https://rwi.lu.se/events/webinar-highlights-covid-19-human-rights-vulnerabilities-and-inequality/ - 2026-10-09
Why the “Global South” matters in young people’s right to a healthy environment - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Adv
https://rwi.lu.se/blog/why-the-global-south-matters-in-young-peoples-right-to-a-healthy-environment/ - 2026-10-09
Lägg till titel Sida 1 av 4 Programråd för Ämneslärarutbildningen PROTOKOLL Datum 2024-09-12 STYR 2024/2244 Programrådets protokoll Ledamöter Närvarande Helena Berglund, bitr. utbildningschef, ordförande Sinikka Neuhaus, utbildningschef ÄLU, från kl 16:15 Sara Håkansson, prodekan, grundutbildningen HT Fabian Beijer, Engelska David Gudmundsson, Religionskunskap Henrik Rosengren, Historia Lukasz Mic
