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Communities living in areas of extraction often find ways to overcome or resist destructive legacies, but researchers lack a deep understanding of the mechanisms by which this is done. This article helps to address this gap by employing the theoretical framework of a sacrifice zone to a case study of Yellowknife, Canada and nearby mining projects. By analyzing a combination of interview and site v
BIOR94 2025 Page 1 of 4 Department of Biology Education- Bachelor's and Master's level COURSE ANALYSIS Date 2025-11-22 Main Teacher: Olivier Van Aken Number of students: 44 Number of answers: 20 Grades: U (7), G (27), VG (8) Course Analysis: “Molecular Biotechnology and Methods”, “BIOR94”, VT25 Summary of the course evaluation The students were overall satisfied with the course, averaging on 3.1/5
Purpose: The purpose of this systematic review was to summarise the evidence from randomised controlled trials examining the effectiveness of physical therapy compared with care as usual or a wait-list condition on eating pathology and on physiological and psychological parameters in patients with anorexia and bulimia nervosa. Method: EMBASE, PsycINFO, PubMed, Cumulative Index to Nursing and Allie
Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in research centers, clinical trials, and clinical settings. However, their broad-scale use is hampered by lack of standardization across analytical platforms and by interference from binding of amyloid-beta(A beta) to matrix proteins as well as self-aggregation. Here, we report on a matrix effect-resistant met
The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D ex
The stem cell factor receptor/c-Kit plays an important physiological role in hematopoesis, melanogenesis and gametogenesis. It has also been implicated in numerous human malignancies. Signal transduction pathways shown to be of importance for c-Kit mediated transformation include the PI3-kinase/Akt pathway. We have previously shown that two alternative splice forms of c-Kit, denoted GNNK- and GNNK
Transient receptor potential vanilloid-1 (TRPV1) has been implicated as a mediator of itch in allergic rhinitis. To address this possibility, we synthesized a TRPV1 blocker (SB-705498) for nasal administration in patients with seasonal allergic rhinitis. The pharmacological activity of SB-705498 was confirmed on human TRPV1-expressing HEK293 cells, using fluorometric calcium imaging, and in patien
PURPOSE: Helicobacter pylori is a human gastroduodenal pathogen associated with type-B gastritis and gastric cancer. Low gastric tissue antioxidant levels are believed to increase the risk of developing gastric cancer. We investigated whether dietary antioxidant levels protect against infection and type-B gastritis in H. pylori-infected guinea pigs. METHODS: Dunkin-Hartley guinea pigs infected for
BACKGROUND: Oct 3/4 (Octamer 3/4), a member of POU family has been considered as an important stem cell marker and essential transcription factor during human embryogenesis. In recent years, there have also been reports on presence of Oct 3/4 in differentiated benign and malignant human cells. The objective of this study was to investigate the transcription and the protein expression of Oct 3/4 is
INTRODUCTION:Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.METHODS:From a prospective population-based coh
PURPOSE: To increase knowledge about pain and general health in adults with myelomeningocele, a health condition with several risk factors for pain such as musculoskeletal deformities, shunt dysfunctions, bowel problems, and urinary tract infections/stones. METHODS: Descriptive correlational pilot study (N= 51, 53% males). Chi-square tests were used to test associations among presence, impact, sev
Background: Erectile dysfunction and lower urinary tract symptoms (LUTS) are common sequelae in men after stroke. Objective: The objective of this study was to evaluate the effect of pelvic floor muscle training (PFMT) on measured erectile function as an indicator of sexuality in men with LUTS after stroke. Method: A sample of 516 men with stroke was invited to participate in this single-blinded,
We have examined concurrent and prospective validity of an index of self-reported walking (RW) of 307 home-dwelling women aged 75 years and above, of whom 155 in 1 year had in all 308 falls of which 13% resulting in fractures. It consists of five items concerning various aspects of self-reported walking identified by factor analysis. The sum score on this ''RW-index'' correlated moderately ( r = 0
The study aims to analyze and explore the factors that affect job satisfaction among nurses working in Emergency Departments. An online questionnaire was implemented to examine the factors that most influence overall job satisfaction among nurses in the Emergency Department. The survey contained items on job characteristics, as well as basic socio-demographics. Based on the results from the qua
Objectives. The subcellular localization of the breast cancer susceptibility gene product BRCA1 has been controversial. Discrepant results have been reported during the past 3 years, partially because of the unavailability of highly specific reagents for BRCA1 protein. Our objective was to characterize the BRCA1-like immunoreactivity that is detected in human seminal plasma by using monoclonal and
Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A–encoding AHSG gene.
PEDS20143675 627..634 Clinical Features of Celiac Disease: A Prospective Birth Cohort Daniel Agardh, MD, PhDa,b, Hye-Seung Lee, PhDb, Kalle Kurppa, MD, PhDc, Ville Simelld, Carin Andrén Aronsson, MSca, Ola Jörneus, MDa, Michael Hummel, MD, PhDe, Edwin Liu, MDf, Sibylle Koletzko, MD, PhDg, for the TEDDY Study Group* abstractOBJECTIVES: To investigate clinical features of celiac disease (CD) and the
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_44_agardh_pediatrics_2015.pdf - 2026-06-02
Mammals express thirteen different isoforms of the membrane-bound water channel aquaporin in a tissue-dependent manner. From a medical point of view, two of the most studied isoforms are aquaporin (AQP0), also known as major intrinsic protein and aquaporin 2 (AQP2). AQP0 is exclusively expressed in the mammalian eye lens and responsible for the transport of water across lens fiber cell membranes t
Background: Plasmodium falciparum parasites cause malaria and co-exist in humans together with B-cells for long periods of time. Immunity is only achieved after repeated exposure. There has been a lack of methods to mimic the in vivo co-occurrence, where cells and parasites can be grown together for many days, and it has been difficult with long time in vitro studies. Methods and results: A new me
PAM50 intrinsic subtyping and risk of recurrence (ROR) score are approved for risk profiling in postmenopausal women. We aimed to examine their long-term prognostic value in terms of breast cancer-free interval (BCFi) and overall survival (OS) (n = 437) in premenopausal women randomised to 2 years of tamoxifen versus no systemic treatment irrespective of hormone-receptor status. Intrinsic subtypin
