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We examined the effect of GH supplementation on the psychological capacity and sense of well-being in 36 patients with adult-onset GH deficiency (GHD). Recombinant human GH was given in a 21-month cross-over, double blind trial, and quality of life was assessed by using three self-rating questionnaires: the Hopkins Symptom Check List (HSCL), the Nottingham Health Profile (NHP), and the Psychologic

OBJECTIVE: The serotonin system has long been of interest in biological models of human personality. The purpose of this positron emission tomography (PET) study was to search for relationships between serotonin 5-HT(1A) receptor density and personality traits. METHOD: Fifteen normal male subjects, ages 20-45 years, were examined with PET and the radioligand [(11)C]WAY100635. Personality traits we

1 Årsrapport 2020 – TEDDY i Covid-19’s tid TEDDY - Omgivningsfaktorer för utveckling av autoimmun (typ 1) diabetes och celiaki hos barn 2 Innehållsförteckning 1. Vad har TEDDY kommit fram till om autoimmun (typ 1) diabetes under 2020? 2. Vad har TEDDY kommit fram till om celiaki (glutenintolerans) under 2020? 3. I vilket land är TEDDY-barnen mest aktiva? 4. TEDDY studiens pågående uppföljning. 5.

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/TEDDY%20%C3%85rsrapport%202020.pdf - 2026-05-28

BACKGROUND: Clinical trials implicate the estrogen receptor (ER) coactivator amplified in breast cancer 1 (AIB1) to be a prognostic and a treatment-predictive factor, although results are not unanimous. We have further investigated this using a controlled randomised trial of tamoxifen versus control. Materials and methods: A total of 564 premenopausal women were entered into a randomised study ind

Objective To establish the clinical relevance of proprioceptive deficits reported after anterior cruciate ligament (ACL) injury. Material and methods A literature search was done in electronic databases from January 1990 to June 2009. Inclusion criteria for studies were ACL deficient (ACL-D) and ACL reconstruction (ACL-R) articles written in English, Dutch or German and calculation of correlation(

Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunoso

Purpose. Patients with fibromyalgia (FM) and chronic widespread pain (CWP) find physical activity troublesome. The purpose was to develop a questionnaire to investigate the experience of physical activity in FM and CWP populations. Method. A questionnaire was developed from a qualitative study. After that, a total of 204 patients with FM or CWP completed the questionnaire. A factor analysis was co

COSM33_2021_schedule 1 COSM33 2021 Human Rights in Asia Course Outline (Preliminary – changes might occur) Course director: Dr. Elizabeth Rhoads Course and Literature Introduction COSM33 is an elective course in the first semester of the MSc in Asian Studies. It is also a stand-alone course open to students from other departments. The aim of the course is to enable students to critically analyse t

https://www.ace.lu.se/sites/ace.lu.se/files/2021-07/COSM33_2021_schedule.pdf - 2026-05-28

Lund University is now taking the next step towards a more secure IT environment. To protect ourselves against today's increased threats, secure passwords alone are not enough; we also need strong authentication to log in to our IT services. Currently, this only applies to Lund University staff, not students.Strong authentication is a way of signing in to an IT service that makes it harder for som

https://www.staff.lu.se/support-and-tools/it-mail-and-telephony/strong-authentication - 2026-05-28

Context: Several text books and articles published between 2000 and 2002 have attempted to introduce experimental design and statistical methods to software engineers undertaking empirical studies. Objective: This paper investigates whether there has been an increase in the quality of human-centric experimental and quasi-experimental journal papers over the time period 1993 to 2010. Method: 70 exp

Purpose. The purpose of this study was to test the General Motor Function Assessment Scale (GMF) for content and criterion validity in geriatric home-rehabilitation. Furthermore, the GMF was analysed with respect to sensitivity, distribution, and for floor and ceiling effects. Method. Content validity was explored by questionnaires circulated to ten experts in the field of geriatrics. Three assess

Objectives: To describe and compare seasonal prevalence, anatomical location, severity, and onset of injuries between female and male elite ice hockey players. Design: Cross-sectional survey study. Setting: Elite ice hockey. Participants: Swedish elite ice hockey players (170 females & 190 males). Main outcome measures: Past season injuries reported on a modified version of the Oslo Sports Tra

Objectives: Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor agonist with antiresorptive and chondroprotective properties. In this study we investigated the effect

Penalty kicks in soccer provide a unique scenario in which to examine human choice behavior under competitive conditions. Here, we report two studies examining the tendency for soccer kickers to select the goal side with the largest area to the left or right of the goalkeeper’s veridical midline, when the goalkeeper stands marginally off-center. In Study I participants viewed realistic images of a

High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been linked with regulating that of HER2, and associated with the development of resistance to HER2-targeted therapies in breast cancer patients. The purpose o

Iran is mainly located in the arid and semiarid climate zone and seriously affected by desertification. This is a severe environmental problem, which results in a persistent loss of ecosys-tem services that are fundamental to sustaining life. Process understanding of this phenomenon through the evaluation of important drivers is, however, a challenging work. The main purpose of this study was to p

Insulin-dependent Type 1 diabetes mellitus is the most common chronic disorder in children and young adults. The genetics, etiology and pathogenesis is complicated by the apparent presence of several genetic region; that contribute to susceptibility. The genetic dissection of Type 1 autoimmune diabetes in the inbred BioBreeding (BB) rat which closely resembles the human disorder was shown to invol

Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes, where skin biopsy assessing intraepidermal nerve fiber density (IENFD) plays an important diagnostic role. In vivo confocal microscopy (IVCM) of the corneal subbasal nerve plexus has been proposed as a noninvasive diagnostic modality for DPN. Direct comparisons of skin biopsy and IVCM in controlled cohorts are lacking, as

Aims: Despite metformin being used as first-line pharmacological therapy for type 2 diabetes, its underlying mechanisms remain unclear. We aimed to determine whether metformin altered DNA methylation in newly-diagnosed individuals with type 2 diabetes. Methods and Results: We found that metformin therapy is associated with altered methylation of 26 sites in blood from Scandinavian discovery and re

Vestibular asymmetry is a common cause of dizziness in the elderly, for whom it precipitates the risk of falling. Previous studies have shown that those with vestibular asymmetry displayed an altered variability in double support time (DST) compared to controls. However, swing time (SwT) variability findings are conflicting. In this study, we investigated if vestibular asymmetry might be causally