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Background Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in pa

The CEBPA gene encodes a transcription factor protein that is crucial for granulocytic differentiation, regulation of myeloid gene expression and growth arrest. Mutations in one or both alleles of CEBPA are observed in about 10% of patients with acute myeloid leukemia (AML). Moreover, other genetic events associated with AML have been identified to deregulate C/EBP alpha expression and function at

Aim: The aim of this study is to explore how women from part of the world where female genital mutilation (FGM) is normative perceive and experience FGM after immigrating to Sweden. Method: Interviews were conducted with eight women from Djibouti, Eritrea, Ethiopia and Somalia. The data were analyzed using qualitative content analysis. Results: The women's feelings were ambivalent: though they opp

Unprecedented global challenges demand wide-reaching societal modification to ensure life support functions and human well-being. In the absence of adequate international responses to climate change and the need for place-based adaptation, local governments have a pivotal role in fostering sustainability transitions. In this context, the importance of ecosystem-based adaptation is increasingly rec

BACKGROUND: The International Outcome Inventory for Hearing Aids (IOI-HA) is a seven-item hearing-specific questionnaire. It was developed with the purpose of evaluating the efficacy of hearing aid rehabilitation. Few psychometric properties have been presented for a Swedish translation of the IOI-HA. Furthermore, previous studies have examined the IOI-HA in mainly sensorineural hearing losses, an

Abstract in UndeterminedPurpose - The purpose of this paper is to describe and analyse ways of organizing integrated care for older persons in Sweden during the past decade. Design/methodology/approach - The data consist of 62 cases of development work, described in official reports. A meta-analysis of cases was performed, including content analysis of each case. A theoretical framework comprising

BACKGROUND: Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may impact the developing lungs and immune system and increase the risk of childhood asthma, but no studies have been conducted in a high-exposed population. The objective of this study was to estimate associations between prenatal PFAS exposure and childhood incidence of asthma and wheeze in Blekinge County, Sweden, whe

Objective Transcriptomic subtyping is not yet standardized for prognostic use in epithelial ovarian cancer (EOC). This study aims to validate RNA sequencing (RNAseq) from formalin-fixed, paraffin-embedded (FFPE) tissues and to evaluate survival-associated transcriptomic subtypes and differentially expressed genes (DEGs) in a clinical trial cohort. Methods An exploratory post hoc analysis was condu

Medical waste management has been receiving increasing attention in recent years. The National Health Service (NHS) of the United Kingdom has started planning its waste strategy to comply with its Net Zero Goals. Waste management does not only involve waste disposal; the process includes segregation, collection, storage, and the transportation of waste from one point to another. Unusual characteri

Introduction: Survivors of critical illness commonly experience physical, cognitive, and psychological impairments. Early rehabilitation may mitigate these impairments; however, how rehabilitation practices are perceived and implemented by healthcare professionals in intensive care unit (ICU) remains insufficiently described. This study aimed to describe healthcare professionals' perceptions of re

Traceability in the dairy supply chain helps ensure high transparency, quality assurance, and regulatory compliance. At the same time, the implementation of traceability in the dairy sector faces several challenges; therefore, this paper examines the factors influencing the implementation of AI-enabled traceability in the Indian dairy industry. The Fuzzy-Decision-Making Trial and Evaluation Labora

Real catalysts consisting of nanoparticles host many nanofacets. Each nanofacet changes its structure and function in response to its local environment but is also affected by neighboring nanofacets. Time-resolved operando experiments close to realistic conditions at polycrystals mimicking real catalyst particles are unfortunately challenging but could be highly rewarding. Here, we demonstrate how

BACKGROUND: Non-operative treatment for acute appendicitis (AA) in children has gained acceptance as an alternative to surgery in selected cases. Accurate preoperative differentiation between perforated and non-perforated AA is increasingly important, as the former requires emergency surgery while the latter may be managed conservatively. Previous research has suggested that low plasma sodium conc

This study develops an integrated decision-support framework for blockchain-enabled Environmental, Social, and Governance (ESG) compliance in global supply networks. Multinational enterprises face complex sustainability challenges due to fragmented supplier systems, inconsistent standards, and limited traceability. Blockchain technology offers transparency, immutability, and decentralized validati

Preventing obsessive–compulsive disorder (OCD) before it emerges has long been considered a central, yet elusive, goal for researchers. Achieving this will likely require identifying individuals at elevated risk and intervening during critical developmental periods before the onset of impairing symptoms. This trial evaluated the feasibility of a brief parent-guided online targeted prevention progr

Virtual Imaging Trials (VITs) provide a reproducible, cost-effective, and ethical approach for testing medical imaging technologies. In breast imaging, realistic phantoms across density levels are crucial, as density affects cancer risk assessment and imaging performance. We have previously demonstrated the use of Perlin noise to simulate breast parenchyma. This study establishes a systematic mapp