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Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was m
The interaction of ultrathin single-crystalline IrO2(110) films with the gas phase proceeds via the coordinatively unsaturated sites (cus), in particular Ircus, the undercoordinated oxygen species on-top O (Oot) that are coordinated to Ircus, and bridging O (Obr). With the combination of different experimental techniques, such as thermal desorption spectroscopy, scanning tunneling microscopy (STM)
Dystrophin of the dystrophin-glycoprotein complex connects the actin cytoskeleton to basement membranes and loss of dystrophin results in Duchenne muscular dystrophy. We have previously shown injury-induced neointima formation of the carotid artery in mice with the mdx mutation (causing dystrophin deficiency) to be increased. To investigate the role of dystrophin in intimal recruitment of smooth m
Popular Abstract in Swedish Katalys är en nyckelteknik inom kemisk industri och spelar en förvånansvärt viktig roll i vårt moderna samhälle. Många av de produkter och kemikalier som används i vårt dagliga liv produceras faktiskt med hjälp av katalysatorer. En annan mycket viktig tillämpning är att avlägsna giftiga ämnen från fordonsavgaser. Det mest fantastiska är att en katalysator snabbar på ochThis PhD thesis reports on investigations of the atomic scale structure of model catalysts relevant for the catalytic oxidation of CO and methane over Pd, and NOx reduction over silver-alumina, important reactions in automotive catalysts. By using complementary experimental techniques such as X-ray Photoelectron Spectroscopy, High Pressure X-ray Photoelectron Spectroscopy, Surface X-ray Diffractio
The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new treatments on epilepsies and comorbidities in humans, using the a
BACKGROUND: Representing is about theories and theory formation. Philosophy of science has a long-standing interest in representing. At least since Ian Hacking's modern classic Representing and Intervening (1983) analytical philosophers have struggled to combine that interest with a study of the roles of intervention studies. With few exceptions this focus of philosophy of science has been on phys
The clinical consequences of arterial atherosclerotic lesions depend, apart from their size, on their composition of cellular and extracellular components. While an intact endothelium at the interface of atherosclerotic plaques towards the blood can prevent its erosion, underlying smooth muscle cells within the plaque can reduce the risk of plaque ruptures, due to the deposition of stabilizing ext
Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. Galectins have e.g.
Two decades have passed since the first attempts were made to establish systematic ethical review of human research in the Baltic States. Legally and institutionally much has changed. In this paper we provide an historical and structural overview of ethical review of human research and identify some problems related to the role of ethical review in establishing quality research environment in thes
To bridge the pressure gap in heterogeneous catalysis and maximize the gain of operando information, we have combined PM-IRRAS with the imaging techniques SOR and PLIF and measured CO oxidation on a Pd(100) crystal.
The regime of excellence - manifested in journal rankings and research assessments is coming to increasing prominence in the contemporary university. Critical scholars have responded to the encroaching ideology of excellence in various ways: while some seek to defend such measures of academic performance on the grounds that they provide accountability and transparency in place of elitism and privi
Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with th
Post-translational modifications (PTMs) such as nitration of Tyr (Y) residues and di-tyrosine (DT) formation are known to impact the aggregation behavior of α-synuclein (α-syn), a protein closely linked to Parkinson's disease. Using tetranitromethane (TNM) as a model nitrating agent, we systematically investigated the chemical modifications of α-syn and their consequences for aggregation. Mass spe
Research infrastructures such as biobanks are increasingly important for science and society. This paper focuses on the transition of biobanks from being a research tool of individual research groups to complex, internationally networked research infrastructures supporting large-scale biomedical investigations, and the challenges that this change poses for governance in relation to management, fun
Importance: Assessment of the causative association between the COVID-19 and cause of death has been hampered by limited availability of systematically performed autopsies. We aimed to present autopsy-confirmed causes of death in patients who died with COVID-19 and to assess the association between thrombosis and diffuse alveolar damage consistent with COVID-19 (DAD). Methods: Consecutive forensic
Entrepreneurship research has been built upon a historical foundation grounded in economic change. To understand the development of the field, it is useful to understand the motivations and interests of key scholars and to trace the linkages between these scholars and other authors, from the transient to the contributor. This has been done through a bibliometric analysis of research articles cited
Climate change mitigation and energy security are partly interacting areas that both present future challenges. The extensive research underway within these areas is mainly conducted in separate research communities, although there are some integrative efforts. This paper examines the breadth and heterogeneity involved in treating energy security and climate change mitigation as a combined researc
