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Background: Assessing and communicating software engineering research can be challenging. Design science is recognized as an appropriate research paradigm for applied research, but is rarely explicitly used as a way to present planned or achieved research contributions in software engineering. Applying the design science lens to software engineering research may improve the assessment and communic
Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather than neurons. Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic su
The Half Heuslers are currently an attractive family of compounds for high temperature thermoelectrics research, and recently, there has been renewed interest since some of these compounds are proposed to be topological insulators. NiTiSn belongs to the family of 18 valence electron Half Heuslers that are predicted to be semiconducting, despite being composed entirely of metallic elements. The gro
Social anxiety disorder (social phobia) is a debilitating and common anxiety disorder, with a lifetime prevalence ranging from 6 % to 12 %. The condition has its onset in childhood and early adolescence, affects females more often than males, and if untreated is associated with high risk of developing comorbid anxiety and mood disorders, as well as substance abuse. The increasingly growing body of
The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated
Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with d
This article discusses the benefits and challenges of adding participant-producedphotographs to qualitative interviewing. The analysis is based on twoqualitative studies aimed at improving the understanding of how residentsexperience and use their a) luminaires and b) window openings. A conveniencesample (N = 12) was asked to take photographs of all luminaires intheir apartments. Facilitated by th
The development of large, software-intensive systems is a complex undertaking that we generally tackle by a divide and conquer strategy. Companies thereby face the challenge of coordinating individual aspects of software development, in particular between requirements engineering (RE) and software testing (ST). A lack of REST alignment can not only lead to wasted effort but also to defective softw
This article examines the way the notion of labour regime in artisanal and small-scale mining (ASM) research can contribute to new ways of conceptualising this sector's challenges. It starts by reviewing how the phenomenal expansion of ASM over the last decades has been problematised, and highlights the need to better understand what drives artisanal miners to operate under extremely precarious wo
