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Transiently binding antibody fragments against Lewis x and sialyl-Lewis x

Biomolecular recognition is often characterised by low affinity where many weak interactions work either alone or in concert, resulting in an inherent dynamic situation. For example the well-studied weak binding of cell-cell interactions is predominantly based on a range of carbohydrates that interact with numerous (protein) ligands. Finding appropriate binders to these carbohydrate structures may

Distance, proximity and types of cross-border innovation systems: A conceptual analysis

Due to a lack of both theoretical and systematic empirical work, innovation-driven integration processes in cross-border areas are still poorly understood. Departing from the regional innovation system (RIS) approach, recent work on different forms of proximity, and the literature on cross-border areas, this paper seeks to identify in a conceptual way different stages in the development of cross-b