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BACKGROUND: BRCA1 and BRCA2 are the two major susceptibility genes involved in hereditary breast cancer. This study was undertaken to provide reliable population-based estimates of genetic influence and to characterize the nature and prevalence of BRCA1 and BRCA2 germline mutations in early-onset breast cancer.METHODS: In a series comprising all women diagnosed with breast cancer under the age of
Currently many Swedish municipalities have big problems with increasing damage costs and difficulties in getting good insurance solutions. Therefore the purpose of this report is to give a proposal of a model for municipal safety management in Gothenburg. This has been achieved by studying statistics and by doing interviews concerning the safety culture in different municipal activities. The most
Equal participation in safe and decent work is a crucial factor for achieving gender equality. Despite this, gender-based obstacles remain as workplaces often fail to ensure the human rights, health, and general wellbeing of their employees, with menstrual health being an especially neglected aspect of the gendered workplace experience. While menstrual health has gained increased attention over th
This study explores how Swedish Generation Z consumers evaluate Perceived Risk when purchasing Private Labels (PLs). While previous PL research has primarily focused on low-involvement grocery products, this study examines how risk evaluations differ across product categories by comparing a premium food product (olive oil) with a semi-durable electronic product (powerbanks). Drawing on Wu et al.’s
BACKGROUND: Pain is a common complaint presented in healthcare, but most epidemiological pain research has focused either on single pain conditions or on the adult population. The aim of this study was to investigate the 2017 consultation prevalence of a wide range of pain conditions in the general population of young people.METHODS: We used the Skåne Healthcare Register, covering prospectively co
Realistic and accurate reconstructions of past vegetation cover are necessary to study past environmental changes. This is important since the effects of human land-use changes (e.g. agriculture, deforestation and afforestation/reforestation) on biodiversity and climate are still under debate. Over the last decade, development, validation, and application of pollen-vegetation relationship models h
Background and Objective: The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia. However, there is very little research on drug-induced cognitive impairment. The aim of this study was to investigate if and how an assessment of cognitive safety was
Purpose: The knowledge about young adults who have lost a parent to cancer is limited, and to reach a broader understanding about this group, this study used the Dual Process Model of Coping with Bereavement (Stroebe and Schut, 1999) as a theoretical framework. The purpose of this study was to describe loss- and restoration-oriented bereavement stressors and psychosocial wellbeing of young adults
Introduction: The risks of preterm birth are known. We investigated the perinatal and infant mortality and morbidity after iatrogenic or spontaneous onset of extremely preterm birth. Material and methods: The present study used data from the population-based EXPRESS study comprising all infants delivered before 27+0 gestational weeks in Sweden between 2004 and 2007. All fetuses alive at admission
Aims and objectives: The aim of this study was to describe how EL was eased, as narrated by frail older people. Background: Existential loneliness (EL) is an unavoidable part of the human condition. It is a complex phenomenon that has been described as disconnection from life. If EL is acknowledged in the care of older people, the experience of EL can be reduced. Design: In this qualitative study,
Background and purpose — Injuries after primary total hip arthroplasty (THA) can be compensated through the National Swedish Patient Insurance Company (Löf). This study examined injury incidence, types, consequences, and subgroup differences in compensated claims following primary THA for osteoarthritis (OA) in Sweden over 10 years. Methods — Data from Löf and the Swedish Arthroplasty Register wer
Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted R
Populärvetenskaplig sammanfattning: Vinderosion på jordbruksmark har länge varit ett välkänt faktum trots att någon utförligare undersökning om dess omfattning och skadeverkan inte tidigare genomförts. Mot bakgrund av detta har därför ett nordeuropeiskt projekt, WEELS (Wind Erosion on European Light Soils), dragits i gång som syftar till kartlägga vinderosionen på sandig jordbruksmark i norra EuroThis work presents the results of a combined field measurement and modeling study of the soil moisture and surface energy balance at Ilstorp near Sjöbo in central Scania. The focus of the study is to investigate the water content of the upper few centimeters of a soil profile. Relevant meteorological variables were measured at the study site during April to June 1999. The field data were used to c
Globally, road traffic accidents (RTAs) remain a major cause of death, particularly among individuals aged 15–30 years. While Sweden has been at the forefront of traffic safety through the Vision Zero initiative, in-hospital management remains crucial in determining RTA outcomes. Drawing on North American evidence suggesting improved survival at trauma centres, the Swedish healthcare system has in
Introduction: Implementing new treatment regimens entails a learning phase with a concomitant risk of suboptimal results. High caseload has generally been shown to improve results in complex surgical procedures. This study aimed to evaluate results of Cytoreductive Surgery (CRS) and Intraperitoneal Chemotherapy (IP), given as Early Postoperative Intraperitoneal Chemotherapy (EPIC) or Hyperthermic
People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.
Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or
