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Intrinsically disordered proteins (IDPs) adopt heterogeneous conformational ensembles in solution. The properties of the conformational ensemble are dependent upon the solution conditions, including the presence of ions, temperature, and crowding, and often directly impact biological function. Many in vitro investigations focus on the properties of IDPs under dilute conditions, rather than the cro
In this article, it is shown that by exposing commonly used lipids for biomembrane mimicking studies, to a solution containing the histidine-rich intrinsically disordered protein histatin 5, a protein cushion spontaneously forms underneath the bilayer. The underlying mechanism is attributed to have an electrostatic origin, and it is hypothesized that the observed behavior is due to proton charge f
Hybrid anisotropic microgels were synthesised using mesoporous silica as core particles. By finely controlling the synthesis conditions, the latter can be obtained with different shapes such as platelets, primary particles or rods. Using the core particles as seeds for precipitation polymerisation, a crosslinked poly(N-isopropylacrylamide) (PNIPAM) microgel shell could be grown at the surface, con
Better understanding of the local deformation of the bone network around metallic implants subjected to loading is of importance to assess the mechanical resistance of the bone-implant interface and limit implant failure. In this study, four titanium screws were osseointegrated into rat tibiae for 4 weeks and screw pullout was conducted in situ under x-ray microtomography, recording macroscopic me
The addition of polyelectrolytes (PEs) to suspensions of charged colloids, such as nanoplatelets (NPs), is of great interest due to their specific feature of being either a stabilizing or a destabilizing agent. Here, the complexation between a PE and oppositely charged NPs is studied utilizing coarse-grained molecular dynamics simulations based on the continuum model. The complex formation is eval
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a significant part of the early colloid literature was focused on protein solutions. However, it has also been recognized that proteins are much more complex than the typical hard sphere-like synthetic model colloids. Proteins are not perfect spheres, their interaction potentials are in general not isot
Simple models based on isotropic interparticle attractions often fail to capture experimentally observed structures of colloidal gels formed through spinodal decomposition and subsequent arrest: the resulting gels are typically denser and less branched than their experimental counterparts. Here, we simulate gels formed from soft particles with directional attractions ("patchy particles"), designed
Seaweed cultivation is a large industry worldwide, but production in Europe is small compared to production in Asian countries. In the EU, the motivations for seaweed farming may be seen from two perspectives; one being economic growth through biomass production and the other being the provisioning of ecosystem services such as mitigating eutrophication. In this paper, we assess the economic potenSeaweed cultivation is a large industry worldwide, but production in Europe is small compared to production in Asian countries. In the EU, the motivations for seaweed farming may be seen from two perspectives; one being economic growth through biomass production and the other being the provisioning of ecosystem services such as mitigating eutrophication. In this paper, we assess the economic poten
A simple Pickering emulsion route has been developed for the assembly of temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) microgel particles into colloidal molecules comprising a small number of discrete microgel interaction sites on a central oil emulsion droplet. Here, the surface activity of the microgels serves to drive their assembly through adsorption to growing polydimethylsiloxa
We present a scheme for transferring conformational degrees of freedom from all-atom (AA) simulations of an intrinsically disordered protein (IDP) to coarse-grained (CG) Monte Carlo (MC) simulations using conformational swap moves. AA simulations of a single histatin 5 peptide in water were used to obtain a structural ensemble, which is reweighted in a CGMC simulation in the presence of a negative
NrdR is a bacterial transcriptional repressor consisting of a zinc (Zn)-ribbon domain followed by an ATP-cone domain. Understanding its mechanism of action could aid the design of novel antibacterials. NrdR binds specifically to two “NrdR boxes” upstream of ribonucleotide reductase operons, of which Escherichia coli has three: nrdHIEF, nrdDG and nrdAB, in the last of which we identified a new
This article explores the rise and fall of social investment (SI) practices in Swedish local government to examine how public-sector reforms are enacted—and undone—in practice. While SI initially promised more preventive, evidence-based and cost-efficient welfare, its local implementation through SI Funds (SIFs) reveals a more complex story. Based on a decade of ethnographically informed research,
Salts affect the solvation thermodynamics of molecules of all sizes; the Hofmeister series is a prime example in which different ions lead to salting-in or salting-out of aqueous proteins. Early work of Tanford led to the discovery that the solvation of molecular surface motifs is proportional to the solvent accessible surface area (SASA), and later studies have shown that the proportionality cons
Abstract in Undetermined The paper compares clothing thermal resistance of the same ensemble tested by different thermal manikins in different laboratories. It also examines the consistence of the two groups of total thermal resistance by Paired-Sample T Test method, which proves that there is no remarkable difference in testing results under the same experiment method and requirement. It is of gr
Template for Theme budget 2024 Calculation of salary costs Calculation of salary costs for employment of less than one year, incl. full compensation for vacation expenses Please fill in the yellow marked fields Name Salary 2022 Adjusted salary with 4% LKP Vacation Months Total % Sum Current vacation expenses TOTAL cost: Coordinator Minnie Mouse 80,000 83,200 44,928 12812.8 8 1,037,837 30% 311,351
https://www.pi.lu.se/en/sites/pi.lu.se.en/files/2023-09/Template%20for%20Theme%20budget%202024%20CL.xlsx - 2026-06-25
4 mars 2026 13:15 till 14:30 | Seminarium Chair: Jon Polk AbstractIn post-conflict settings, holding perpetrators accountable is widely viewed as essential for restoring the rule of law and rebuilding institutional legitimacy. Yet, justice providing authorities face the challenge of walking a fine line between under- and over-punishment of former enemies: sanctions perceived as too lenient may sig
Professor emeritus Kontaktinformation E-post: anders [dot] lindroth [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsAnders Lindroths profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Professor emeritus Institutionen för naturg
https://www.nateko.lu.se/sv/anders-lindroth - 2026-06-25
Affilierad forskare Kontaktinformation E-post: erik_johan [dot] mobrand [at] soclaw [dot] lu [dot] seOrganisation Rättssociologiska institutionen Hämtställe: 31 WebbplatsErik Johan Mobrands profil i Lunds universitets forskningsportalForskningsområdenDemokrati och lagInternationellt vetenskapligt samarbete och politikAsien: sammanhang och sociala teorierPågående forskningJag forskar om politiska o
https://www.soclaw.lu.se/erik-johan-mobrand - 2026-06-25
