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Dwell time is crucial for railway operations, for example, 20% of the total travel time in a mass transit context in the Paris region. With this, it is also a source of delays due to its variability. One way to ensure the robustness of a timetable is to add margins as buffer time that can be consumed to absorb short delays. Much work has been done on run time margins, but dwell time margins receiv

The recent identification of fragile X-associated tremor ataxia syndrome (FXTAS) associated with premutations in the FMR1 gene and the possibility of clinical overlap with multiple system atrophy (MSA) has raised important questions, such as whether genetic testing for FXTAS should be performed routinely in MSA and whether positive cases might affect the specificity of current MSA diagnostic crite

Background: In the Malmö Diet and Cancer study, information on dietary habits was obtained through a modified diet history method, combining a 7-day menu book for cooked meals and a diet questionnaire for foods with low day-to-day variation. Half way through the baseline data collection, a change of interview routines was implemented in order to reduce interview time. Methods: Changes concentrated

Degradation of the dry semiarid ecosystems in the Mu Us Sandy Land of north central China was explored using high-resolution satellite images from 1978, 1987 and 1996. This study monitored both changes in grassland biomass production and reclamation activities to detect the nature and scale of land degradation since major economic reforms were introduced in 1978. The position of the high-resolutio

Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi raci

Colour vision models require measurement of receptor noise and the absorbance of visual pigments, oil droplets, and ocular media. We have studied how variation in these parameters influences colour matching, spectral sensitivity, and colour discrimination predictions in four bird species. While colour match predictions are sensitive to variation in visual pigment and oil droplet absorbance data, d

Background: It is unclear to what extent primary care practitioners (PCPs) should retain responsibility for follow-up to ensure that patients are monitored until their symptoms or signs are explained. Aim: To explore the extent to which PCPs retain responsibility for diagnostic follow-up actions across 11 international jurisdictions. Design and setting: A secondary analysis of survey data from the

Type specimens of Sympycnus pulicarius, S. annulipes, S. cinerellus and S. desoutteri were examined to clear up a long-lasting taxonomic confusion. Our study revealed that they represent, together with S. pygmaeus and S. annulipes var. brunnitibialis, a single species, with S. pulicarius as the senior subjective synonym, which is redescribed in this paper. Lectotypes were designated for Dolichopus

Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan con

Methane (CH4) fluxes 1997-2010 were studied by combining remotely sensed normalised difference water index (NDWI) with in situ CH4 fluxes from Rylekaerene, a high-Arctic wet tundra ecosystem in the Zackenberg valley, north-eastern Greenland. In situ CH4 fluxes were measured using the closed-chamber technique. Regression models between in situ CH4 fluxes and environmental variables [soil temperatur

The role of thalidomide for previously untreated elderly patients with multiple myeloma remains unclear. Six randomized controlled trials, launched in or after 2000, compared melphalan and prednisone alone (MP) and with thalidomide (MPT). The effect on overall survival (OS) varied across trials. We carried out a meta-analysis of the 1685 individual patients in these trials. The primary endpoint wa

High precision single-differential W±-boson production cross-sections as a function of electron or muon transverse momentum pT or their pseudorapity η, as well as double-differential cross-sections as functions of these variables, are measured in proton–proton collisions at centre-of-mass energies s=5.02 TeV and 13 TeV. The W-boson charge asymmetry as a function of lepton η is also measured. The d

This paper presents the feasibility of estimating discharges from RoseiresReservoir (Sudan) for the period from 2002 to 2010 and Aswan High Dam/Lake Nasser(Egypt) for the periods 1999-2002 and 2005-2009 using satellite altimetry and imagerywith limited in situ data. Discharges were computed using the water balance of thereservoirs. Rainfall and evaporation data were obtained from public domain dat