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Cinnamoyl-CoA reductase (CCR), an enzyme central to the lignin biosynthetic pathway, represents a promising biotechnological target to reduce lignin levels and to improve the commercial viability of lignocellulosic biomass. However, silencing of the CCR gene results in considerable flux changes of the general and monolignol-specific lignin pathways, ultimately leading to the accumulation of variou

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Although the main aim of clubfoot correction is to create a foot without limitations in daily activities and sport, studies on the walking capacity of children with corrected clubfeet are rare. In this cross-sectional study, the outcome of the six-minute walking test in 44 children with clubfeet (16 unilateral and 28 bilateral, mean age 8.57±2.45 years) was compared with the reference values of Ge

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The influence of temperature, salts, pH, and various pre-treatments and cleaning on the nanofiltration (NF) performance of thin-film polyamide (PA) composite membranes has been investigated. The change in membrane performance was correlated to membrane swelling or/and electroviscous friction. Aspects of costs and energy demand while using NF at elevated temperatures were also evaluated. The increa

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In two miniature artificial language learning experiments, we compare the processing of narrow and broad negation, corresponding to prefixal negation (unhappy) and free-standing negation (not happy) respectively, with that of non-negation (happy). Three artificial prefixes were invented to express the three meanings above. The meaning scope expressed by the negation types was manipulated in the ex

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Denna avhandling undersöker vetenskapens roll i den politiska processens tidiga stadier. Detta görs genom att studera hur "geoengineering" kommer upp på den politiska agendan. Begreppet ”geoengineering” används även på svenska och beskriver en uppsättning idéer om hur man stabiliserar den globala temperaturen genom att ingripa i jordens miljösystem. Begreppet mötte stark skepsis i det vetenskapligThis thesis examines the role of science in the earliest stages of the political process. It does this by studying the emergence of ‘geoengineering’ on the political agenda. The term describes a set of ideas on how to stabilize global temperature by intervening into the Earth’s natural systems, and was subject to a strong taboo in the scientific community until the mid-2000s. Yet within a decade,

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A persistent controversy in language evolution research has been whether language emerged in the gestural-visual or in the vocal-auditory modality. A "dialectic" solution to this age-old debate has now been gaining ground: language was fully multimodal from the start, and remains so to this day. In this paper, we show this solution to be too simplistic and outline a more specific theoretical propo

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Lateralization is a fundamental property of the human brain that affects perceptual, motor, and cognitive processes. It is now acknowledged that left-right laterality is widespread across vertebrates and even some invertebrates such as fruit flies and bees. Honeybees, which learn to associate an odorant (the conditioned stimulus, CS) with sucrose solution (the unconditioned stimulus, US), recall t

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Standard interpolation techniques are implicitly based on the assumption that the signal lies on a single homogeneous domain. In contrast, many naturally occurring signals lie on an inhomogeneous domain, such as brain activity associated to different brain tissue. We propose an interpolation method that instead exploits prior information about domain inhomogeneity, characterized by different, pote

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Reason(s) for writing and research problem(s): This article analyzes the experiences retold by former concentration camp detainees who were placed in concentration camps like civilians at the beginning of the Bosnian war in the 1990s. Aims of the paper (scientific and/or social): The article aims to describe the recounted social interaction rituals after time spent in a concentration camp as well

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Aquaporins are transmembrane proteins that facilitate the flow of water through cellular membranes. An unusual characteristic of yeast aquaporins is that they frequently contain an extended N terminus of unknown function. Here we present the X-ray structure of the yeast aquaporin Aqy1 from Pichia pastoris at 1.15 Å resolution. Our crystal structure reveals that the water channel is closed by the N

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A new global atmospheric carbon dioxide (CO2) real-time forecast is now available as part of the pre- operational Monitoring of Atmospheric Composition and Climate – Interim Implementation (MACC-II) service us- ing the infrastructure of the European Centre for Medium- Range Weather Forecasts (ECMWF) Integrated Forecast- ing System (IFS). One of the strengths of the CO2 fore- casting system is that

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Purpose: Muda is a Japanese term literally meaning futility, uselessness, idleness, superfluity, waste, wastage or wastefulness. The term was introduced by the Japanese engineer Taiichi Ohno of Toyota Motor Corporation in the 1960s. Therefore, reducing and minimizing Muda is an effective way to increase the operational efficiency and productivity of an organization’s processes. In turn, the techni

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Ever since Goldin-Meadow, S., C. Mylander, W. C. So, and A. Özyürek. 2008. The natural order of events: How speakers of different languages represent events nonverbally. PNAS 105: 9163–9168. proposed that there is a preferred order in sequential non-verbal event representations (Actor > Patient > Act), apparently independent of the default word order in one’s native language, the topic has been th

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Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane of plants, allowing the vacuole to efficiently sequester ammonium ions and counteract cytosolic fluctuations of ammonia. Here, we report the structure determined at 1.18 Å resolution from twinned crystals of Arabidopsis thaliana aquaporin AtT