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The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a potential strategy for developing novel analgesics. Here we validated this strategy by examining
Oxalate oxidase catalyses the degradation of oxalic acid to carbon dioxide and hydrogen peroxide and is of commercial importance for clinical analyses of oxalate in biological samples. Novel potential applications for oxalate oxidase include the prevention of the formation of calcium oxalate incrusts in pulp and paper manufacture and rapid determination of oxalic acid in process waters. The potent
Poland’s List of Monarchs and the La Fontaine Fable in a Moralizing Work of Swedish Eighteenth-Century Literature The paper elucidates a work of Early Modern Swedish literature, entitled Polska Kongars Saga och Skald [Saga and Song of Polish Kings] and published anonymously at the royal printing house in Stockholm in 1736. This book is remarkable in several respects. In 51 chapters it portrays th
The aim of this thesis was to study the chemical communication involved in aggressive and reproductive behaviours in the European lobster (Homarus gammarus). Both male and female H. gammarus established and maintained dominance, but the sexes used different strategies for dominance maintenance. Male losers recognised individual fight opponents and avoided them but fought actively against unfamil
Popular Abstract in Swedish Cancer är en komplex och heterogen sjukdom där celler har börjat växa okontrollerat och denna sjukdom är idag ett stort hälsoproblem. På grund av diffusa symptom upptäcks cancern ofta i ett sent stadium. Otillräcklig kunskap om olika fenotyper hindrar utvecklingen av riktad behandling och patienter svarar därför väldigt olika på en given behandling. Denna avhandling ärCancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. Insufficient understanding of the different phenotypes hinders the development of targeted therapeutics and consequently patients show a diverse range of responses to a given treatment. This thes
Popular Abstract in Swedish Hemicellulosa är en fantastisk källa av förnyelsebar råvara, vars användning har potental att bli kraftigt utökad i framtiden. Hemicellulosor är tillsammans, med lignin och cellulosa bland de mest förekommande klasserna av ämnen i växtcellernas väggar. Dessa tre beståndsdelar är tätt sammanlänkade, vilket gör det svårt att separera dem från varandra. Hemicellulosor är kHemicelluloses are tremendous sources of renewable raw materials, which utilisation have the potential to be highly increased in the future. Hemicelluloses are among the major groups of compounds in plant cell walls, together with cellulose and lignin. These three components are closely associated, making them difficult to separate from each other. Hemicelluloses are complex polysaccharides and tw
Popular Abstract in English Heme is a small red-colored molecule consisting of an iron atom bound to a chemical structure called porphyrin. Heme is essential for many organisms, including humans, because it is a cofactor in a variety of proteins that are needed to sustain metabolism. The probably most famous heme protein is hemoglobin which gives blood its red color. The heme cofactor in hemoglobiHeme proteins form a large and diverse group of proteins which are involved in a variety of biological functions. The heme prosthetic group enables them to carry out redox reactions, transport electrons, bind gaseous molecules, and function as sensors. Despite their importance only little is generally known about heme protein biogenesis. The Gram-positive bacterium Enterococcus faecalis is found i
Popular Abstract in Swedish Inledningen syftar till att ge en översikt över Swedenborgs levnadslopp och ge en viss orientering i litteraturen kring honom. Det visar sig att det saknas en grundlig idéhistorisk studie över hans tidiga mekanistiska naturfilosofi. Föreliggande bok kan sägas vara en kognitiv idéhistoria som har siktet inställt på hur han tänkte. I arbetet med Swedenborgs naturfilosofi The Swedish natural philosopher Emanuel Swedenborg (1688–1772) thought in his early scientific career that the world was like a gigantic machine, following the laws of mechanics and geometry. The work presented here is a study of his mechanistic worldview and metaphorical way of thinking up to the year 1734, examining most of his fields of interest, from geometry and metaphysics to technology and
Popular Abstract in Swedish Helicobacter pylori är en bakterie som orsakar såväl magkatarr, magsår som magsäckscancer. H. pylori producerar olika virulensfaktorer såsom enzymet ureas, ett cell vakuolbildande toxin (VacA), andra cytotoxiska proteiner (cagA eller pathogenicity island-associated proteins), flageller och adhesiner. För etablering av H. pylori infektion, måste dessa virulensfaktorer inHelicobacter pylori is a gastric pathogen which cause chronic type B gastritis and peptic ulcer disease. H. pylori produces virulence factors such as urease, vacuolating cytotoxin VacA, cag pathogenicity island-associated proteins, flagella and adhesins. These proteins interact with several host cell molecules such as sialylated cell surface glycoproteins, some of glycolipids and mucins. Glycosami
Aim The aim here was to assess whether the present-day assemblage of subantarctic flowering plants is the result of a rapid post-Last Glacial Maximum (LGM) colonization or whether subantarctic flowering plants survived on the islands in glacial refugia throughout the LGM. Location The circumpolar subantarctic region, comprising six remote islands and island groups between latitudes 46 degrees and
P2Y(2) receptors, which mediate contractile and mitogenic effects of extracellular nucleotides in vascular smooth muscle cells (VSMCs), are upregulated in the synthetic phenotype of VSMCs and in the neointima after balloon angioplasty, suggesting a role in the development of atherosclerosis. Because released cytokines in atherosclerotic lesions mediate multiple effects on gene transcription in VSM
Popular Abstract in Swedish Cancer är den vanligaste dödsorsaken bland barn mellan 1–14 år i Sverige. Neuroblastom, som nästan uteslutande drabbar barn, är en aggressiv cancersjukdom som har sitt ursprung i det sympatiska (icke-viljestyrda) nervsystemet. I frisk vävnad råder strikt balans mellan celldelning och celldöd, medan cancerceller kännetecknas av en ohämmad celldelning och minskad celldödNeuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of h
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer
Background: Dose-dense (DD) adjuvant chemotherapy improves outcomes in early breast cancer (BC). However, there are no phase 3 randomized data to inform on its combination with trastuzumab for patients with human epidermal growth factor receptor 2 (HER2)–positive disease. Methods: This was a protocol-predefined secondary analysis of the randomized phase 3 Pan-European Tailored Chemotherapy (PANTHE
Syftet med studien var att undersöka pedagogikens betydelse för bemötande av och omvårdnad om barn med autism inom den somatiska vården. Ytterligare ett syfte var att undersöka personalens och föräldrarnas upplevelser av hur barn med autism blir bemötta inom den somatiska vården. Dessutom undersöktes föräldrarnas upplevelser av att ha ett barn med autism. Fem personal inom den somatiska vården sam
Title: Are we born gifted or can we learn and teach our children to be musically interested? The aim of this study is to evaluate how we influence the development of musicality in children. The study included 30 persons divided into three groups (ten members in each group). Group 1 consisted of pregnant women. Group 2 consisted of parents of babies age 0 to 1 year old and group 3 teenage parents.
Title: What shall we play? -A study of the importance of genre spread in music education. The aim of this study is to examine music teachers' and music students' reflections on the importance of genre spread in music education. The study covers music education in municipal primary schools and municipal music schools/schools of arts and music. I have used both quantitative and qualitative m
Title: The competent teacher-external and internal frameworks and their influence on educational praxis. This thesis is about what kind of approach a teacher (may) consider when he is facing parameters that he can not do anything about, in this case represented by political, educational och social frameworks. One of the things a teacher can do to adapt to the situation is to see what possibilities
