Sökresultat

Recently several distinct literatures have thematically converged around the topic of non-European state-making: political scientists – both comparativists and international relations scholars, historical sociologists, comparative and world historians, anthropologists, archaeologists and others, have begun to interest themselves in state making or state formation in non-European settings, and also

Thromboembolic events are the second cause of death in cancer patients, although the mechanisms underlying this increased thromboembolic risk remain unclear. The aims of this study were to examine whether BRCA2 gene mutations may modify the circulating levels of thrombocoagulation biomarkers and whether breast cancer development may influence changes in such circulating biomarkers. The study was p

Eye-tracking research in infants and older children has gained a lot of momentum over the last decades. Although eye-tracking research in these participant groups has become easier with the advance of the remote eye-tracker, this often comes at the cost of poorer data quality than in research with well-trained adults (Hessels, Andersson, Hooge, Nyström, & Kemner Infancy, 20, 601-633, 2015; Was

OBJECTIVE: To develop a prognostic model to predict disease outcomes in individual patients with Parkinson disease (PD) and perform an external validation study in an independent cohort.METHODS: Model development was done in the Comorbidity and Aging in Rehabilitation Patients: The Influence on Activities (CARPA) cohort (Netherlands). External validation was performed using the Cambridgeshire Park

INTRODUCTION: We have limited knowledge about the underlying disease mechanisms and causes of pain in hand osteoarthritis (OA). Consequently, no disease-modifying drug exists, and more knowledge about the pathogenesis of hand OA is needed, as well as a validation of different outcome measures. Our first aim of this study is to explore the validity of various imaging modalities for the assessment o

Objectives: The paper describes recruitment results and characteristics of the UP-TECH clinical trial sample, including level of care services use, informal caregiver burden and its determinants.Methods: UP-TECH is designed to test innovative care solutions for community-dwelling patients with moderate stage Alzheimer's disease and their caregivers in Italy. Four hundred and fifty patient-caregive

One of the conclusions from comparative empirical studies of the structural challenges towards making global production and consumption patterns compatible with environmental limits is that rich countries would need to ‘degrow’ (O’Neill 2015; Fritz and Koch 2016). To shed light on the potential role of the state in such a planned downscaling process the paper compares state roles in a capitalist e

Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name

In this study we investigated the neurocognitive processes underlying the control of memory retrieval. In a Think/No-Think paradigm, adopted for the use in an event-related potential (ERP) experiment, participants learned word pairs and were subsequently presented with cue words and asked to either suppress or to recall the target word. During final cued recall tests for all initially learned targ

Excitatory amino acids are implicated in the development of neuronal cell damage following periods of reversible cerebral ischemia or insulin-induced hypoglycemic coma. To explore the importance of glutamate receptor activation in the posthypoglycemic phase, we exposed rats to 20 min of insulin-induced severe hypoglycemia. The rats were treated immediately after the hypoglycemic insult with four r

The effect of different glutamate‐receptor antagonists on the induction of cortical spreading depression of Leao and of cortical anoxic membrane depolarization were investigated in the anaesthetized rat. Spreading depression (SD), elicited by mechanical stimulation of the cortical surface, was inhibited by the non‐competitive N‐methyl‐d‐aspartate (NMDA)‐receptor blocker, (±)‐5‐methyl‐10,11‐dihydro

From in situ measured woody cover we develop a phenology driven model to estimate the canopy cover of woody species in the Sahelian drylands at 1km scale. The model estimates the total canopy cover of all woody phanerophytes and the concept is based on the significant difference in phenophases of dryland trees, shrubs and bushes as compared to that of the herbaceous plants. Whereas annual herbaceo

Purpose: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been repor

Lactobacillus reuteri metabolises glycerol efficiently to form 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3PDO) by the same mechanism as that for 1,2-propanediol (1,2PDO) conversion to propionic acid and propanol via its propanediol utilization (pdu) pathway. Pdu enzymes are encoded by the pdu-operon, which also contain genes encoding the shell proteins of the microcompartment housing t

Inhibition of mitochondrial permeability transition (mPT) has emerged as a promising approach for neuroprotection and development of well-tolerated mPT inhibitors with favorable blood-brain barrier penetration is highly warranted. In a recent study, 28 clinically available drugs with a common heterocyclic structure were identified as mPT inhibitors e.g. trifluoperazine, promethazine and nortriptyl

The quantum theory of measurement has been with us since quantum mechanics (QM) was invented. It has recently been invigorated, partly due to the increasing interest in quantum information science. In this, partly pedagogical review, I attempt to give a self-contained overview of the basis of (non-relativistic) QM measurement theory expressed in density matrix formalism. I will not dwell on the ap

Background: In egg-laying animals, mothers can influence the developmental environment and thus the phenotype of their offspring by secreting various substances into the egg yolk. In birds, recent studies have demonstrated that different yolk substances can interactively affect offspring phenotype, but the implications of such effects for offspring fitness and phenotype in natural populations have