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Since the rise of radical geography in the early 1970s, political economy has been crucial in examining the spatial dynamics of capital in economic geography. Marxist and non-Marxist (particularly institutionalist) economic geographers use political economy to challenge non-political economy approaches that ignore the relationship between microeconomic processes and their spatial manifestations an
Reversible phosphorylation is an important regulatory mechanism. Regulation of protein phosphorylation in β-cells has been extensively investigated, but less is known about protein dephosphorylation. To understand the role of protein dephosphorylation in β-cells and type 2 diabetes (T2D), we first examined mRNA expression of the type 2C family (PP2C) of protein phosphatases in islets from T2D dono
When referring to non-present entities, speakers and signers can select from a range of different strategies to create expressions that range from extremely concise to highly elaborate. This design of referring expressions is based partly on the availability of contextual information that can aid addressee understanding. In the small signing community of Providence Island, signers' heavy reliance
Groupexhibition. Philip Dufva, Maria Hedlund och Eva Löfdahl.6 juli 2024–6 oktober 2024Jag betraktar allt som passerar mina ögon och testar det mot ett behov”.Citatet ovan, liksom utställningens titel, är hämtat från Eva Löfdahl – en konstnär som arbetar i många olika material och tekniker, alltid med det specifika behovet hos detta speciella verk som utgångspunkt – snarare än en färdig idé, ett u
Background: Genetic variants in SEC61A1 are associated with autosomal dominant tubulointerstitial kidney disease. SEC61A1 is a translocon in the endoplasmic reticulum membrane and variants affect biosynthesis of renin and uromodulin. Methods: A patient is described that presented at 1 year of age with failure-to-thrive, kidney failure (glomerular filtration rate, GFR, 18 ml/min/1.73m2), hyperkalem
Home heating transitions influence sociocultural practices and bring about structural changes in daily life. To uncover the power dynamics underpinning these transformations, this paper applies a visionary framework for feminist energy systems designed to challenge hegemonic and unsustainable energy cultures in pursuit of a more just and equitable future. Drawing on the framework's political, econ
Current models for understanding the spatial diffusion of innovation exhibit significant limitations when it comes to explaining how transformative innovations in sectors of the foundational economy travel between cities and countries. Transformative innovations in infrastructure sectors like water, energy, or waste management are typically not reducible to single products or technologies but rely
Since the rise of radical geography in the early 1970s, political economy has been crucial in examining the spatial dynamics of capital in economic geography. Marxist and non-Marxist (particularly institutionalist) economic geographers use political economy to challenge non-political economy approaches that ignore the relationship between microeconomic processes and their spatial manifestations an
A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m
Introduction: Of newly diagnosed cases of haemophilia B, the proportion of sporadic cases is usually 50% of severe cases and 25% of moderate/mild cases. However, cases presumed to be sporadic due to family history may not always be sporadic. Few case reports have been published on mosaicism in haemophilia B. Aim: The present study aimed to trace the origin of the pathogenic variant in a well-defin
BACKGROUND: A blood-based test for the early detection of Parkinson's disease (PD) would be an important diagnostic tool and useful for patient selection when developing novel drugs or treatments for the disease.OBJECTIVE: Here, we aimed to identify potential biomarkers associated with PD.METHODS: We applied gene expression profiling to the study of peripheral blood from 75 healthy control subject
Vapor transport in porous media, often associated with liquid-vapor phase change, is an fundamental process in many emerging underground energy storage and extraction processes (i.e., seasonal solar thermal aquifer storage, geothermal extraction, extraterrestrial in-situ water extraction). By jointly using experimental imaging and numerical modeling at the micro-scale, we conduct mechanistic pore
Instituting (Athens, 2021)What could processes of self-organizing and collective making look like in the current landscape? In what ways might they affect public processes of social improvisation? How might such forms of “instituting” give rise to other forms of institutions? Inviting theoretical as well as practical approaches, this edition of the New Alphabet School studies “instituting” as an i
Background: The purpose of treating toxic nodular goitre (TNG) is to reverse hyperthyroidism, prevent recurrent disease, relieve symptoms and preserve thyroid function. Treatment efficacies and long-term outcomes of antithyroid drugs (ATD), radioactive iodine (RAI) or surgery vary in the literature. Symptoms often persist for a long time following euthyroidism, and previous studies have demonstrat
Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alle
According to Lefebvre, modern capitalism has led to the commodification of urban life. Even though commodification has taken multiple distinct forms across the urban fabric, it could be argued that no urban feature is more representative of the proliferation of exchange values than shopping malls. Despite being privately owned and managed, commercialised and highly securitised, shopping malls have
Barn med svår cerebral pares har ofta avvikande tillväxt. År 2000 infördes inom Barn- och ungdomshabiliteringen i Region Skåne ett NutritionsÅtgärdsProgram (NÅP) med mål att tillförsäkra adekvata nutritionsinsatser för dessa barn för att växa och utvecklas optimalt. Syftet med studien var att undersöka om programmet har haft effekt för vikt- och längdtillväxten hos barn med cerebral pares, nivå IV
Syftet med föreliggande studie var att undersöka sjuksköterskors kunskap och användning av befintliga bedömningsinstrument för oral hälsa samt undersöka den kliniskt verksamma sjuksköterskans dokumentation beträffande den orala hälsan på vårdavdelningar med hög andel äldre patienter. Metoden var en enkätstudie som besvarades av 90 sjuksköterskor från åtta avdelningar på Helsingborgs Lasarett. Resu
Jämlikhet och delad föräldraledighet har idag en framträdande ställning i den svenska politikens agenda. Pappor betraktas som lika del av föräldraskapet som mammor. Syfte: Syftet med föreliggande studie var att beskriva pappors upplevda behov av och inställning till deltagande i föräldragrupper. Metod: En kvalitativ intervjustudie utfördes med 15 småbarnspappor om deras syn på föräldragrupper och
Bakgrund: Långvarig smärta är ett vanligt och relativt välstuderat hälsoproblem som i stor utsträckning påverkar individens dagliga liv. I vilken omfattning detta sker samt vilka grupper som drabbas mest är emellertid mer sparsamt undersökt. Syfte: Syftet med föreliggande studie var att undersöka smärtans påverkan på dagligt liv ur ett köns- och åldersperspektiv. Metod: Metoden är kvantitativ och
