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Carotid sinus massage (CSM) as integral part of cardiovascular autonomic testing, is indicated in all patients > 40 years with syncope of unknown origin and suspected reflex mechanism. However, large practice variation exists in performing CSM which inevitably affects the positivity rate of the test and may result in an inaccurate diagnosis in patients with unexplained syncope. Even though CSM was
OBJECTIVES: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.METHODS: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82). Efficacy endpoints were assessed in patients without high-titre inhibitors/immune tolerance induction (n = 67).RESULT
Feedback loops are among the core notions in systems thinking – and the various fields of theory and practice that draw on it, including systemic design. We use these notions to develop methodological approaches, conceptualise processes, assess the adequacy of solutions, and anticipate how the design object may interact with its immediate surroundings and beyond. In my presentation, I discuss the
Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predic
This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active
Med utgångspunkt i repertoar med rötter i folkmusik från Iberiska halvön fortsätter Groupa sitt arbete med att skapa helt nya musikaliska uttryck baserade på traditionsmusik. Detta är det fjärde albumet i serien Kind of Folk, här i samarbete med spanska och portugisiska musiker. Medverkar gör slagverksduon Ttukunak Txalaparta, bestående av Maika Gomez och Sara Gomez, sångerskan och slagverkaren Va
Introduction: In low- and middle-income countries such as India, private pharmacies play an important role in medical treatments, offering advice for common illnesses such as diarrhea and respiratory tract infections. There is a need to explore the details of the dispensing practices at the private pharmacies in low- and middle-income countries.Methodology: The present study used simulated client
Deep electrification powered by renewable sources has emerged as a pivotal strategy for achieving ambitious CO2 emission reduction targets. However, the true impact of electrification on decarbonization remains inadequately measured because the whole energy chain has not yet been fully considered. This study combines Societal Exergy Accounting and Logarithmic Mean Divisia decomposition analysis to
An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen–antibody complexes to enable the identification of protective epitopes using the cytolytic exotoxin
The study of microbial diversity over time and space is fundamental to the understanding of their ecology and evolution. The underlying processes driving these patterns are not fully resolved but can be studied using population genetic approaches. Here we investigated the population genetic structure of Gonyostomum semen, a bloom-forming phytoplankton species, across two continents. The species ap
The present article elaborates on struggles over the inclusion and exclusion of undocumented children and young people in the Swedish school system. Through conducting an in-depth case study on the issue of access to school in the city of Malmö in Sweden, our analysis demonstrates how the right to education for undocumented migrant children is subject to a process of struggle between divergent dis
Bakgrunn.I 2007 kom det anbefalinger om at serumkonsentrasjonen av digitoksin bør ligge i området 8 – 15 nmol/l, noe som er ca. halvparten av det som tidligere var ansett som optimalt, og forslag til nye doseringsrutiner.Materiale og metode.Utviklingen for angitt dosering og serumkonsentrasjoner av digitoksin er undersøkt med utgangspunkt i 13 054 prøver sendt til Avdeling for klinisk farmakologi
The formation of platoons, where groups of vehicles follow each other at close distances, has the potential to increase road capacity. In this paper, a decentralized control approach is presented that extends the well-known constant headway vehicle following approach to the two-dimensional case, i.e., lateral control is included in addition to the longitudinal control. The presented control scheme
Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase (Tat). The Tat machinery exports folded and cofactor-containing proteins from the cytoplasm to the periplasm by using the transmembrane proton motive force as a source of energy. The Tat apparatus apparently senses the folded state of its pr
BACKGROUND: Cerebral palsy (CP) is a clinical diagnosis and was long categorized as an acquired disorder, but more and more genetic etiologies are being identified. This review aims to identify the clinical characteristics that are associated with genetic CP to aid clinicians in selecting candidates for genetic testing.METHODS: The PubMed database was systematically searched to identify genes asso
Reverse Logistics Networks (RLNs) have grown in importance after return policies became compulsory. Lately, questions have been raised whether they effectively decrease environmental impact: efforts to optimize the eco-efficiency of RLNs through minimizing costs and emissions were deployed, but results are not advancing with the necessary speed. Alternatively, the eco-effectiveness ("doing the rig
Hair can record chemical information reflecting our living conditions, and, therefore, strands of hair have become a potent analytical target within the biological and forensic sciences. While early efforts focused on analyzing complete hair strands in bulk, high spatial resolution mass spectrometry imaging (MSI) has recently come to the forefront of chemical hair-strand analysis. MSI techniques o
