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Engineered multidomain cysteine protease inhibitors yield resistance against western flower thrips (Franklinielia occidentalis) in greenhouse trials

Western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripiclae), cause very large economic damage on a variety of field and greenhouse crops. In this study, plant resistance against thrips was introduced into transgenic potato plants through the expression of novel, custom-made, multiclomain protease inhibitors. Representative classes of inhibitors of cysteine and aspartic

Social influence interpretation of interpersonal processes and team performance over time using Bayesian model selection

The team behavior literature is ambiguous about the relations between members’ interpersonal processes—task debate and task conflict—and team performance. From a social influence perspective, we show why members’ interpersonal processes determine team performance over time in small groups. Together, over time, dissenting in-group minorities who share information (via debate) with majorities, who s

Assessing sources of uncertainty in formaldehyde air mass factors over tropical South America: Implications for top-down isoprene emission estimates

We use a nested-grid version of the GEOS-Chem chemistry transport model, constrained by isoprene emissions from the Model of Emissions of Gases and Aerosols from Nature (MEGAN), and the Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS) bottom-up inventories, to evaluate the impact that surface isoprene emissions have on formaldehyde (HCHO) air-mass factors (AMFs) and vertical column densit

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.

The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention.

Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.

Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th

Intimal Hyperplasia in Balloon Dilated Coronary Arteries is Reduced by Local Delivery of the NO Donor, SIN-1 Via a cGMP-Dependent Pathway.

BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox

Hidden Markov model likelihoods and their derivatives behave like i.i.d. ones

We consider the log-likelihood function of hidden Markov models, its derivatives and expectations of these (such as different information functions). We give explicit expressions for these functions and bound them as the size of the chain increases. We apply our bounds to obtain partial second order asymptotics and some qualitative properties of a special model as well as to extend some results

Generation of ultrashort coherent vacuum ultraviolet pulses using electron storage rings : A new bright light source for experiments

We demonstrate for the first time that seeded harmonic generation on electron storage rings can produce coherent optical pulses in the vacuum ultraviolet spectral range. The experiment is performed at Elettra, where coherent pulses are generated at 132nm, with a duration of about 100fs. The light source has a repetition rate of 1kHz and adjustable polarization; it is very bright, with a peak power

A new analytical method for lead determination in atmospheric particulate matter by a combination of ultrasound-assisted extraction and supramolecular solvent preconcentration

Air pollution by lead, even in small concentrations, can cause serious health effects. In the atmosphere this element can generally be found in particulate matter (PM), and in general in small concentrations. This work proposes the development of an analytical method for lead determination in inhaled PM based on ultrasound-assisted extraction with subsequent supramolecular solvent based dispersive

Accuracy and precision of statistical descriptors obtained from multidimensional diffusion signal inversion algorithms

In biological tissues, typical MRI voxels comprise multiple microscopic environments, the local organization of which can be captured by microscopic diffusion tensors. The measured diffusion MRI signal can, therefore, be written as the multidimensional Laplace transform of an intravoxel diffusion tensor distribution (DTD). Tensor-valued diffusion encoding schemes have been designed to probe specif

Interference between direct and resonant channels in near-resonance photoemission in argon

The photoelectron spectra of argon was demonstrated during resonant photoemissions. The interference effects of the photoelectron spectra of argon was monitored by following the intensity of final states through resonant and direct channels. The need for a unified one-description of the ionization through a direct and core-excitation mediated channel was described.

Imaging of the vulnerable carotid plaque : Role of imaging techniques and a research agenda

OBJECTIVES: Atherothrombosis in the carotid arteries is a main cause of ischemic stroke and may depend on plaque propensity to complicate with rupture or erosion, in turn related to vulnerability features amenable to in vivo imaging. This would provide an opportunity for risk stratification and-potentially-local treatment of more vulnerable plaques. We here review current information on this topic

Evaluation of aerosol and cloud properties in three climate models using MODIS observations and its corresponding COSP simulator, as well as their application in aerosol-cloud interactions

The evaluation of modelling diagnostics with appropriate observations is an important task that establishes the capabilities and reliability of models. In this study we compare aerosol and cloud properties obtained from three different climate models (ECHAM-HAM, ECHAM-HAMSALSA, and NorESM) with satellite observations using Moderate Resolution Imaging Spectroradiometer (MODIS) data. The simulator M

Comparisons of historical Dutch commons inform about the long-term dynamics of social-ecological systems

Human societies and natural ecosystems are under threat by growing populations, overexploitation of natural resources and climate change. This calls for more sustainable utilization of resources based on past experiences and insights from many different disciplines. Interdisciplinary approaches to studies of historical commons have potential to identify drivers of change and keys to success in the

Substantial heritable variation in recombination rate on multiple scales in honeybees and bumblebees

Meiotic recombination shuffles genetic variation and promotes correct segregation of chromosomes. Rates of recombination vary on several scales, both within genomes and between individuals, and this variation is affected by both genetic and environmental factors. Social insects have extremely high rates of recombination, although the evolutionary causes of this are not known. Here, we estimate rat

Predicting the Energy Performance of Buildings : A Method using Probabilistic Risk Analysis for Data-driven Decision-support

Byggnaders energieffektivitet är ett fokusområde i arbetet med att minska klimatförändringarna, då byggnader står för cirka 40 procent av den totala energianvändningen i Europeiska unionen. En lösning som tillämpas för att minska byggnaders energibehov är att ständigt införa strängare byggregler. Följaktligen ökar betydelsen av precisa och effektiva simuleringar för att kunna beräkna byggnaders frAs most countries worldwide continue to mitigate climate change, one area of focus is a building's energy efficiency. Buildings currently account for approximately 40 per cent of the total energy use in the European Union. One solution for reducing the energy demand from buildings is by continually implementing more stringent building regulations. Consequently, the importance of accurate and effic

Taurine effects on bisphenol a-induced oxidative stress in the mouse testicular mitochondria and sperm motility

Objectives: This study was performed to investigate the protective effects of taurine (2-aminoethanesulfonic acid, TAU) on oxidative stress in the isolated mouse testicular mitochondria, mitochondrial membrane potential (MMP), viability and motility of the exposed sperms to the BPA. Methods: We treated epididymal spermatozoa obtained from mice and isolated mouse testicular mitochondria with BPA (0

Palaeoproterozoic reworking of early Archaean lithospheric blocks : Rocks and zircon records from charnockitoids in Volgo-Uralia

The Volgo-Uralia segment, which constitutes one fourth of the East European Craton, is covered by sedimentary deposits. From geophysical studies and examination of thousands of drillcores, Volgo-Uralia has been recognised as a vast high-grade terrain with a complex crustal history extending from the Palaeoarchaean to the Palaeoproterozoic. Our recent studies are focused on the search for the oldes