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OBJECTIVE: There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function. METHODS: FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The l
this study we investigated the effects of gastrectomy (Gx) and of the gastric hormone, ghrelin, on the expression of proteins in brown adipose tissue (BAT) that are thought to be involved in thermogenesis. Heat production in BAT is known to depend upon activation and increased expression of β3-adrenergic receptors (β3-AR) and the consequent up-regulation of uncoupling protein 1 (UCP1). Mice were s
The electronic coupling strength within columns of discotic liquid crystals is investigated using core-level Coexisting well-ordered and disordered regions are identified in thin films of tetra-alkoxy-substituted phthalocyanines with the aid of near edge X-ray absorption fine structure and photoelectron spectroscopies. These different regions Lire used to derive a lower limit for the intermolecula
To investigate whether interstitial cells (ICs) are present in the adult mouse bladder, and what transmitters characterize adjacent nerve fibres, as ICs in human and guinea-pig bladder lie close to nerve fibres but transmitters present in these nerves have not yet been reported. Sections of the bladder wall from 12 adult male mice (six each, aged 3-4 or 18-24 months) were incubated in carboxygenat
1. Fungus-growing termites live in an obligate mutualistic symbiosis with Termitomyces fungi. The functions of the fungal symbiont have been hypothesised to differ between species and to range from highly specific roles of providing plantdegrading enzymes complementary to termite gut enzymes, to non-specific roles of providing protein-rich food to the termites. 2. Termite species with unspecialise
Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolat
Electron-ion-ion coincidence measurements carried out at discrete resonances near the N 1s threshold in ammonia are reported. The measured coincidence spectra show clear alignment of the molecule upon resonant core-electron excitation. The coincidence data are analyzed to extract information about the molecule in the excited state by simulating the alignment and the dissociation processes. Dynamic
Alcohol dependence is a devastating illness affecting a large population, and new pharmacological treatments with good efficacy are greatly needed. One potential candidate is varenicline, a smoking cessation agent with partial agonist action at α4 β2 nicotinic acetylcholine receptors.
Exciton dynamics in alternating copolymer/fullerene solar cell blends have been investigated using femtosecond transient absorption spectroscopy. The acceptor concentrations have been varied over a wide range. Experimental data, kinetic modeling and simulations, all indicate that the efficiency of exciton conversion to charges is 100% even at acceptor concentrations as low as 20 wt%. The reported
The team behavior literature is ambiguous about the relations between members’ interpersonal processes—task debate and task conflict—and team performance. From a social influence perspective, we show why members’ interpersonal processes determine team performance over time in small groups. Together, over time, dissenting in-group minorities who share information (via debate) with majorities, who s
Molecular docking is a computational approach that predicts interactions between ligands and protein targets based on binding energies. In this study, the potential interactions of 1,8-cineole -one of the dominant components of Eucalyptus globulus oil- with the main protease (Mpro) and macrodomain (MacI) of SARS-CoV-2 were studied by molecular docking. Nine Mpro and four ManI structures available
En hermeneutisk undersökning av hur manlighet skildras i kvinnliga trubadurers minnelyrik från högmedeltida Occitanien. Uppsatsen diskuterar lyrikens kontext och trobairitzernas korpus, för att sedan analysera de 26 dikter som med störst sannolikhet verkligen är skrivna av trobairitzerna. Analysen fokuserar på vilka egenskaper männen i lyriken tillskrivs, hur männen figurerar i förhållande till ly
Purpose: To define hyperphysical retail, and present theoretical aspects which should be considered when a company wants to create their own hyperphysical installation. Methodology: A qualitative dual case study with secondary data utilizing an abductive method to develop the interpretation of the phenomenon by consistently working between the cases and the selected theories. Findings: This paper
Diverse perspectives are essential to the advancement of biodiversity science, yet persistent structural biases continue to shape who is seen and heard in academic spaces. Despite efforts to promote inclusivity, it remains unclear whether increased representation translates into equitable visibility and engagement from peers. Seminar talks, key arenas for idea exchange and networking, offer a wind
Meiotic recombination shuffles genetic variation and promotes correct segregation of chromosomes. Rates of recombination vary on several scales, both within genomes and between individuals, and this variation is affected by both genetic and environmental factors. Social insects have extremely high rates of recombination, although the evolutionary causes of this are not known. Here, we estimate rat
Byggnaders energieffektivitet är ett fokusområde i arbetet med att minska klimatförändringarna, då byggnader står för cirka 40 procent av den totala energianvändningen i Europeiska unionen. En lösning som tillämpas för att minska byggnaders energibehov är att ständigt införa strängare byggregler. Följaktligen ökar betydelsen av precisa och effektiva simuleringar för att kunna beräkna byggnaders frAs most countries worldwide continue to mitigate climate change, one area of focus is a building's energy efficiency. Buildings currently account for approximately 40 per cent of the total energy use in the European Union. One solution for reducing the energy demand from buildings is by continually implementing more stringent building regulations. Consequently, the importance of accurate and effic
Objectives: This study was performed to investigate the protective effects of taurine (2-aminoethanesulfonic acid, TAU) on oxidative stress in the isolated mouse testicular mitochondria, mitochondrial membrane potential (MMP), viability and motility of the exposed sperms to the BPA. Methods: We treated epididymal spermatozoa obtained from mice and isolated mouse testicular mitochondria with BPA (0
The Volgo-Uralia segment, which constitutes one fourth of the East European Craton, is covered by sedimentary deposits. From geophysical studies and examination of thousands of drillcores, Volgo-Uralia has been recognised as a vast high-grade terrain with a complex crustal history extending from the Palaeoarchaean to the Palaeoproterozoic. Our recent studies are focused on the search for the oldes
