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Case study research plays an important role for social and political scientists working within the qualitative tradition, with the field of international relations (IR) being no exception. This article provides methodological reflections on the challenges of investigating ‘elusive’ cases within the global governance domain of IR. Taking stock of my experience of studying global multi-stakeholder p

The Gaussian β-ensemble is a real n-point configuration {xj}n1 picked randomly with respect to the Boltzmann factor e− β 2 Hn, where Hn = ∑i≠j log |xi−1xj| + n ∑ni=112 xi2. It is well known that the point process {xj }n1 tends to follow the semicircle law σ (x) = 21π√(4 − x2 )+ in certain average senses. A Fekete configuration (minimizer of Hn) is spread out in a much more uniform way in the inter

In recent years, Skylarks Alauda arvensis have undergone dramatic population declines in many European countries. Evidence exists for deteriorating conditions during the breeding season, but little is known about the situation during the rest of the annual cycle. Here we use two approaches to test if the Dutch breeding population of Skylarks consists of resident and/or migratory individuals. First

The association between a randomly pyrene labeled PAA polymer (PAAMePy55) and a PEO-PPO-PEO triblock copolymer (P123) in aqueous solutions of different NaCl concentrations and pHs has been studied by means of dynamic light scattering (DLS) and steady-state fluorescence spectroscopy at 40 °C. At acidic pH values, in the low P123/PAAMePy55 molar ratio regime (i.e., at low P123 concentrations), the r

Legislation in Sweden and the European Union concerning the use of sewage sludge in agriculture is under revision and future concentration limits for pathogens in treated sludge are likely to be expected. The aim of this study was to evaluate the hygienization of Salmonella, Escherichia coli, Enterococcus and Clostridium perfringens through continuous anaerobic digestion at 35, 55 or 60 ºC as well

Context: Inflammation and adipogenesis are two parallel processes with increased activity in severe Graves' ophthalmopathy. Objective: The aim of this work was to define target genes for therapeutic intervention in adipogenesis and inflammation in Graves' ophthalmopathy. Design: Orbital tissue was obtained from patients with ophthalmopathy in acute or chronic phase undergoing orbital surgery to st

Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their r

The utility of the GHOST(3) cell assay has been evaluated for testing coreceptor use of primary human immunodeficiency virus type 1 (HIV-1) isolates. GHOST(3) cells were derived from the human osteosarcoma cell line, HOS, and have been engineered to stably express CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, Bonzo, or the orphan receptor BOB. The Indicator cell line carries

Basic electrochemistry of glassy carbon paste electrodes (GCPEs) modified with Meldola Blue adsorbed on crystalline a-titanium phosphate (MB-a-TP) electrodes and their ability to catalyze the NADH oxidation have been investigated. Various ratios of glassy carbon (Sigradur K) to MB-alpha-TP, were used to obtain GCPEs. Cyclic voltammetry (CV) and rotating disc electrode (RDE) measurements, performed

Background. Although schizophrenia is the fifth leading cause of disability-adjusted life years worldwide in people aged 15 to 44 years, the clinical evidence of physical therapy as a complementary treatment remains largely unknown. Purpose. The purpose of this study was to systematically review randomized controlled trials (RCTs) evaluating the effectiveness of physical therapy for people with sc

A QM/MM investigation of the active-ready (Hox) form of [FeFe]-hydrogenase from D. desulfuricans, in which the electronic properties of all Fe-S clusters (H, F and F') have been simultaneously described using DFT, was carried out with the aim of disclosing a possible interplay between the H-cluster and the accessory iron-sulfur clusters in the initial steps of the catalytic process leading to H2 f

A density functional theory study is presented regarding the energetics and the Mulliken population analyses of a quantum mechanical/molecular mechanical (QM/MM) system including multiple iron-sulfur clusters in the QM region. The [FeFe]-hydrogenase from Desulfovibrio desulfuricans was studied, and both the active site (an Fe6S6 assembly generally referred to as the H-cluster) and an ancillary Fe4

The aim of this study was to determine the risk and burden of vertebral fractures judged as those coming to clinical attention and as morphometric fractures. Incidence and utility loss were computed from data from Malmo, Sweden. Clinical fractures accounted for 23% of all vertebral deformities in women and for 42% in men. The average 10-year fracture probability for morphometric fractures increase

The aim of this study was to determine the threshold of fracture probability at which interventions become cost-effective. We modeled the effects of a treatment costing $500/year, given for 5 years, that decreased the risk of all osteoporotic fractures by 35%, followed by a waning of effect for 5 years. Sensitivity analyses included a range of effectiveness (10%-50%) and a range of intervention co

Purpose: We compared ProstaLund Feedback Treatment(R) (PLFT(R)) to transurethral prostate resection (TURP) in terms of efficacy and safety in a pooled analysis of 3 clinical studies with 1-year followup. Materials and Methods: Overall raw data on 183 patients with PLFT(R) and 65 with TURP were pooled. All studies had identical inclusion criteria, and the efficacy and safety of the method were eval

Ethanol production by the yeast Saccharomyces cerevisiae from dilute acid lignocellulose hydrolyzate was studied with the aim to improve fuel ethanol production. Specifically, the problem of inhibition was addressed. Lignocellulose hydrolyzate contains not only sugars, but also several compounds, such as furfural and 5-hydroxymethyl furfural (HMF), which can inhibit yeast growth and ethanol produc

Essä om mytbildningen kring slavupproret 73-71 fvt i romarriket och användningen av SPartacus som nationell och politisk symbol i modern tid. Arthur Koestlers roman The Gladiators (1952)jämförs med Howard Fasts roman Spartacus och Dalton Trumbos filmmanus till Stanley Kubricks Spartacus (1960). Även skillnaden mellan Trumbos manus och Kubricks film diskuteras.