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Since potential changes in the dynamics and mobility of drugs upon complexation for delivery may affect their ultimate efficacy, we have investigated the dynamics of two local anesthetic molecules, bupivacaine (BVC, C18H28N2O) and ropivacaine (RVC, C17H26N2O), in both their crystalline forms and complexed with water-soluble oligosaccharide 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The study was ca

Reactive oxygen species and redox signaling undergo synergistic and antagonistic interactions with phytohormones to regulate protective responses of plants against biotic and abiotic stresses. However, molecular insight into the nature of this crosstalk remains scarce. We demonstrate that the hydrogen peroxide-responsive UDP-glucosyltransferase UGT74E2 of Arabidopsis thaliana is involved in the mo

This paper deals with the description of two new species of Horismenus Walker (Hymenoptera: Eulophidae) from Brazil, parasitoids of larvae of Adetus analis (Haldeman) (Coleoptera: Cerambycidae). Both species are similar to Horismenus steirastomae (Girault), a species that also parasitizes cerambycids. Adetus analis is a pest of Sechium edule (Jacq.) Swartz (Cucurbitaceae), a minor crop in Brazil,

In many application domains, critical systems must comply with safety standards. This involves gathering safety evidence in the form of artefacts such as safety analyses, system specifications, and testing results. These artefacts can evolve during a system's lifecycle, creating a need for impact analysis to guarantee that system safety and compliance are not jeopardised. Although extensive resear

Biodiversity conservation requires an understanding of the extent to which a landscape can contribute to species life-cycle. Conceived as a dynamic mosaic of spatial units with different properties, landscape is a very relevant scale for dealing with biodiversity issues. This paper aims at analysing the relationships and overlapping between this geography and landscape ecology as two scientific fi

The multimedia era has started. The migration of computer (packet oriented) and telephony (circuit switched) networks in combination with an explosive development of new services, creates a mass market for public broadband communication. There are no reasons foreseen why these kinds of services should not go mobile. Future customers will not treat a mobile access differently than a fixed access to

This paper deals with the design of channel estimators in the uplink of an OFDM based multi-user system. First, we propose a user allocation scheme that is based on the aim to use the correlation of the radio channel for channel estimation purposes. Further, we present the linear MMSE channel estimator based on a few pilot tones. We present an error analysis that proves valuable in the evaluation

The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independen

Wavelet-based statistical parametric mapping (WSPM) is an extension of the classical approach in fMRI activation mapping that combines wavelet processing with voxel-wise statistical testing. We recently showed how WSPM, using graph wavelets tailored to the full gray-matter (GM) structure of each individual’s brain, can improve brain activity detection compared to using the classical wavelets that