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Measuring the wedge of flat optical windows

A novel interferometric technique to measure small wedge angle of transparent windows is proposed. The technique is based on the measurement of the shift of the interference pattern generated by two sheared copies of a laser beam after crossing the optical wedge. A simple lens is used to combine the two beams in their focal plane and measurements are taken for different shears. It is not necessary

Detection of Copy Number Aberration and Tumor Fraction in Archival Cervical Specimens from Ovarian Cancer Patients using Shallow Whole Genome Sequencing.

Ovarian cancer, often called the silent killer due to its diffuse symptoms at early stage, poor prognosis after treatments and high mortality, is also a heterogeneous disease consisting of different histological subtypes with potentially different origins. About 90% of all cases derive from epithelial cells and high-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive form of e

Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT2CRs), is a new FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain disorders, such as addiction and epilepsy. The modulation of dopaminergic function might be critical in the therapeutic effect of lorcaserin, but its exact effect is unknown. Here, we studied the effect of the peripheral admini

Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency

3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. Here, we report for the first time a very mild form of genetically confirmed 3-PGDH deficiency in two siblings with juvenile onset of absence seizures and mild developmental delay. Amino acid analysis showed se

Exploring the Interface Between Public Demand and Private Supply for Implementation of Circular Economy Principles

The Ph.D. dissertation consists of three connected, yet independent research articles, which focus on the implementation of circular economy principles in public procurement. Motivated by a curiosity for dynamics in processes of implementation I chose to investigate how actors related to processes of public procurement can implement the circular economy principles as a default. The aim of the diss

Tilt table testing, methodology and practical insights for the clinic

Tilt table testing (TTT) has been used for decades to study short-term blood pressure (BP) and heart rate regulation during orthostatic challenges. TTT provokes vasovagal reflex in many syncope patients as a background of widespread use. Despite the availability of evidence-based practice syncope guidelines, proper application and interpretation of TTT in the day-to-day care of syncope patients re

Quantification of annual settlement growth in rural mining areas using machine learning

Studies on annual settlement growth have mainly focused on larger cities or incorporated data rarely available in, or applicable to, sparsely populated areas in sub-Saharan Africa, such as aerial photography or night-time light data. The aim of the present study is to quantify settlement growth in rural communities in Burkina Faso affected by industrial mining, which often experience substantial i

Moderators of outcome in a web-based substance use intervention for adolescents.

Aims: In this article we explore the moderators of effectiveness of WISEteens (Web-based brief Intervention for SubstancE using teens), a fully automated web-based brief motivational intervention targeting risky substance use among adolescents. Based on previous studies, we examined the differential effects on drinking of sex, readiness to change, self-efficacy, alcohol risk status, and parental m

Patient-reported Outcomes after Primary Total Hip Arthroplasty Are Not Affected by the Sex of the Surgeon : A Register-based Study of 8,383 Procedures in Western Sweden

Introduction: Female surgeons remain a minority within the field of orthopaedics, particularly in certain specialties such as arthroplasty. There is no scientific evidence on whether the surgeon's sex affects the patient-reported outcome after orthopaedic surgery such as total hip arthroplasty (THA). We therefore aimed to investigate the association between surgeon sex and health-related quality o

Game over for automated vehicles?

Trials with automated mini buses (AV shuttles) are going on in many cities. According to game-theoretic reasoning, in mixed traffic normal road users will soon take advantage of the defensive driving style of the AV shuttles, and may eventually totally block their accessibility (Camara et al., 2018; Michieli & Badia, 2018; Millard-Ball, 2018). So far there are few studies on the interaction be

Adaptive, maladaptive, neutral, or absent plasticity : Hidden caveats of reaction norms

Adaptive phenotypic plasticity may improve the response of individuals when faced with new environmental conditions. Typically, empirical evidence for plasticity is based on phenotypic reaction norms obtained in reciprocal transplant experiments. In such experiments, individuals from their native environment are transplanted into a different environment, and a number of trait values, potentially i

The age and country rock provenance of the Molopo farms complex : Implications for transvaal supergroup correlation in southern Africa

The ultramafic-mafic layered igneous Molopo Farms Complex straddles the border between South Africa and Botswana. Younger cover obscures this igneous complex and its country rocks, which are generally assigned to the Paleoproterozoic Transvaal Supergroup. The area intruded by the complex is characterized by abutting and contrasting successions of the upper Transvaal Supergroup (i.e., the Pretoria

Complications in emergency department patients with acute coronary syndrome with contemporary care

INTRODUCTION: With the implementation of early reperfusion therapy, the number of complications in patients with acute coronary syndrome (ACS) has diminished significantly. However, ACS patients are still routinely admitted to units with high-level monitoring such as the coronary or intensive care unit (CCU/ICU). The cost of these admissions is high and there is often a shortage of beds. The aim o

Assessment of Precipitation Deficit in the São Francisco River Basin From 1998 to 2018

This work presents an assessment of the precipitation deficit in the São Francisco River Basin (SFRB) based on temporal, seasonal and regional analyses of two decades of precipitation data products derived from satellite missions launched since 1997. The temporal analyses were performed by means of three 3-month SPI time series, consisting of 250 values each derived from TRMM, CHIRPS and PERSIANN-

Impact of the energy crisis on indoor temperatures and thermal comfort in UK houses during winter 2023

Geopolitical, health and economic events have led to an accumulated surge in energy prices in the UK at the beginning of the 2020s. In response, studies and media reports show that households have had to reduce the running of their heating systems to cut their energy bills. However, there is limited research on the impact of this context on indoor thermal conditions and occupants’ ability to meet

Enabling nature-based solutions for climate adaptation in cities of the Global South : planning dimensions and cross-cutting pathways for implementation

Despite the increasing recognition of the critical role that nature-based solutions (NBS) play in urban resilience, decision-makers in many cities across the Global South continue to prioritize grey infrastructure and engineered solutions. This prevailing approach may offer short-term economic advantages but ultimately falls short in ensuring the long-term sustainability and resilience of communit