Sökresultat

Reversible phosphorylation is an important regulatory mechanism. Regulation of protein phosphorylation in β-cells has been extensively investigated, but less is known about protein dephosphorylation. To understand the role of protein dephosphorylation in β-cells and type 2 diabetes (T2D), we first examined mRNA expression of the type 2C family (PP2C) of protein phosphatases in islets from T2D dono

Instituting (Athens, 2021)What could processes of self-organizing and collective making look like in the current landscape? In what ways might they affect public processes of social improvisation? How might such forms of “instituting” give rise to other forms of institutions? Inviting theoretical as well as practical approaches, this edition of the New Alphabet School studies “instituting” as an i

The aim of this article is to show that at the end of the 13th century there’s a change of approach to the sophistical syllogism, going from a definition based on its formal features to a definition based on its pragmatic features. The first position is put forward by Simon of Faversham, during the 1280s, probably during his stay in Paris. The second position is put forward by Radulphus Brito, the

Background: Genetic variants in SEC61A1 are associated with autosomal dominant tubulointerstitial kidney disease. SEC61A1 is a translocon in the endoplasmic reticulum membrane and variants affect biosynthesis of renin and uromodulin. Methods: A patient is described that presented at 1 year of age with failure-to-thrive, kidney failure (glomerular filtration rate, GFR, 18 ml/min/1.73m2), hyperkalem

Ibland kan man som lärare undra om man lever som man lär. En sak är i alla fall säker, vi lär som vi lever! Vårt nya stressade levnadssätt påverkar givetvis vårt sätt att lära. Under en kort tidsrymd har tre tekniska produkter påverkat lärandet mer än vad läroplaner eller vetenskapliga pedagogiska genombrott någonsin gjort - datorn, internet och mobiltelefonen. Bodil myntar att vi idag lever på

Sustainable development “which meets the needs of the present without compromising the ability of future generations to meet their own needs,” (WCED 1987) is a global development objective of paramount importance. However, on the ground, ‘sustainable development’ is – in my experience – often little more than a buzzword for securing grants. From a strong sus-tainability standpoint, this thesis doc

Performance audit has become increasingly common in the public administration and every western democracy has today an independent National Audit Office (NAO). However, although the external requirements may be met, the functioning of these agencies may be jeopardized by internal and more subtle cultural factors relating to the role of the performance auditor. In Sweden, a new NAO called Riksrevis

A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m

Vapor transport in porous media, often associated with liquid-vapor phase change, is an fundamental process in many emerging underground energy storage and extraction processes (i.e., seasonal solar thermal aquifer storage, geothermal extraction, extraterrestrial in-situ water extraction). By jointly using experimental imaging and numerical modeling at the micro-scale, we conduct mechanistic pore

Groupexhibition. Philip Dufva, Maria Hedlund och Eva Löfdahl.6 juli 2024–6 oktober 2024Jag betraktar allt som passerar mina ögon och testar det mot ett behov”.Citatet ovan, liksom utställningens titel, är hämtat från Eva Löfdahl – en konstnär som arbetar i många olika material och tekniker, alltid med det specifika behovet hos detta speciella verk som utgångspunkt – snarare än en färdig idé, ett u

BACKGROUND: A blood-based test for the early detection of Parkinson's disease (PD) would be an important diagnostic tool and useful for patient selection when developing novel drugs or treatments for the disease.OBJECTIVE: Here, we aimed to identify potential biomarkers associated with PD.METHODS: We applied gene expression profiling to the study of peripheral blood from 75 healthy control subject

The study of microbial diversity over time and space is fundamental to the understanding of their ecology and evolution. The underlying processes driving these patterns are not fully resolved but can be studied using population genetic approaches. Here we investigated the population genetic structure of Gonyostomum semen, a bloom-forming phytoplankton species, across two continents. The species ap

Introduction: Of newly diagnosed cases of haemophilia B, the proportion of sporadic cases is usually 50% of severe cases and 25% of moderate/mild cases. However, cases presumed to be sporadic due to family history may not always be sporadic. Few case reports have been published on mosaicism in haemophilia B. Aim: The present study aimed to trace the origin of the pathogenic variant in a well-defin

Background: The purpose of treating toxic nodular goitre (TNG) is to reverse hyperthyroidism, prevent recurrent disease, relieve symptoms and preserve thyroid function. Treatment efficacies and long-term outcomes of antithyroid drugs (ATD), radioactive iodine (RAI) or surgery vary in the literature. Symptoms often persist for a long time following euthyroidism, and previous studies have demonstrat

Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alle

This article reviews some of the communicative strategies of plant-based meat, a food innovation that promises an experience akin to that of animal meat, but devoid from its harmful consequences relating to the well-being of humans, animals, and the planet. Mobilizing a constitutive approach on communication, we trace the founding narrative of the Beyond Meat firm using various documents, which en