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Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm that follows a heterogeneous clinical course. Recurrent mutations have been described, but their applicability in the clinical setting is currently limited. The main reasons are challenges in the sequencing of DNA retrieved from formalin-fixed tissue commonly used for tissue collection in clinical biobanks. In this study, we sequenced 77
Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains controversial in ecological model systems. We used whole-genome bisulfite sequencing of individual water fleas (Daphnia magna) to assess whether environmentally induced DNA methylation is transgenerationally inherited. Genetically identical
Meetings are common in contemporary working life, but they are often overlooked in academic studies and sometimes defined as empty or boring by employees. Yet, the meeting society isbeing reproduced again and again. There seem to be hidden ways to incorporate meetings into today’s working life without arousing critique about pointless activities and deviations from what should really be done. One
There has been little, or no, direct testing of theories of gas sorption within particular pores situated amidst a highly inter-connected pore network. The concept of thermodynamically independent pores within networks has also been challenged. In this work, a novel integrated nitrogen sorption and mercury porosimetry technique has been used to deconvolve the condensation and evaporation processes
This paper presents the first optimal, maximal likelihood, solution to the triangulation problem for radially distorted cameras. The proposed solution to the two-view triangulation problem minimizes the L2-norm of the reprojection error in the distorted image space. We cast the problem as the search for corrected distorted image points, and we use a Lagrange multiplier formulation to impose the ep
We apply the statistical sparse jump model, a recently devel-oped, interpretable and robust regime switching model, to infer key featuresthat drive the return dynamics of the largest cryptocurrencies. The algorithmjointly performs feature selection, parameter estimation, and state classifica-tion. Our large set of candidate features are partly based on cryptocurrency,sentiment and financial market We apply the statistical sparse jump model, a recently devel-oped, interpretable and robust regime switching model, to infer key featuresthat drive the return dynamics of the largest cryptocurrencies. The algorithmjointly performs feature selection, parameter estimation, and state classifica-tion. Our large set of candidate features are partly based on cryptocurrency,sentiment and financial marke
This article furthers political geographic thinking on democracy by generating and employing a conceptualisation of ‘assemblage-democracy’. Bringing an assemblage perspective to democratic thinking brings to the fore three key dimensions: the co-constitution of material and non-material connections; connectivity and associations, in particular engagement with multiple heterogeneous ‘minoritarian’
Is more child participation always better for child rights advocacy? That is the question I examine, in this chapter, as I analyse advocacy for child rights in India that led to the adoption of the landmark Protection of Children from Sexual Offences Act, 2012 (the ‘POCSO Act’). Through ethnographic fieldwork with non-government organisations (NGOs) and a narrative analysis of interviews and aware
Abstract in UndeterminedIn this paper the question “Why software vendors focus on roles when they aim at developing the future enterprise resource planning (ERP) systems?” is discussed. At the moment there is increasing interest in developing ERP systems that support a person's different working roles in the organisation, which could be described as role-based ERPs. It could be asked whether this
Two new solvates were prepared in the system Cu(I) I using a solvolysis reaction. The structures for both of them were solved by X-ray crystallography, showing that they constitute two modifications of the same compound with the net formula [Cu4I6](P(C6H5)(4))(2)center dot 2OC(CH3)(2). Both types of crystals show vivid fluorescence when exposed to UV light. The formation of the first modification
In this study, the production of enantiomerically pure (1R,4S,6S)-6-hydroxy-bicyclo[2.2.2]octane-2-one ((-)-2) through stereoselective bioreduction was used as a model reaction for the comparison of engineered Saccharomyces cerevisiae and engineered Escherichia coli as biocatalysts. For both microorganisms, over-expression of the gene encoding the NADPH-dependent aldo-keto reductase YPR1 resulted
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi
Forskning kring tidigt liv möter svårigheter utöver de som forskning kring senare liv ställs inför. På grund av att de tidigaste bergarterna inte finns bevarade har viktig information om jordens tidiga förhållanden för evigt gått förlorad. Dessutom var de tidigaste livsformerna små och morfologiskt enkla, vilket betyder att abiotiska pseudofossil lätt kan infiltrera fossilarkivet. Ett centralt tem
Conducted between the months of January and March 2012 in Eldoret Kenya, this study sought to find out why the internally displaced women of Yamumbi IDP Camp A remained trapped in the displacement camp. The study sought the opinions and views of the women. By applying qualitative approach method of semi-structured interviews and focus group discussions hand-recorded data was collected. Using purpo
Rökning är fortfarande ett stort hälsoproblem. Hårt drabbade ärofrivilliga, passiva rökare som barn i familjer med rökandeföräldrar. Syftet med denna studie var att undersöka hur och i vilkenutsträckning barn påverkas respiratoriskt av passiv rökning inomfamiljen samt att undersöka vilka preventiva åtgärder somvidtagits mot detta. Litteraturstudien bestod av fjorton vetenskapligaartiklar inom områ
Trots att både sjuksköterskor och läkare arbetar mot samma mål, ett optimalt välbefinnande för patienten, visar många studier på att samarbetet dem emellan är bristfälligt. Syftet med studien var att undersöka hur sjuksköterskor upplever det interprofessionella samarbetet med läkare samt hur detta i sin tur påverkar omvårdnaden. Materialet inhämtades genom åtta bandinspelade intervjuer med sjukskö
Vanligt är att tidiga tecken på kognitiv dysfunktion efter hjärtkirurgi varken upptäcks eller behandlas förrän den är uppenbar. Av patienterna upplever 22% kognitiv dysfunktion. Sjuksköterskan saknar ofta utbildning för att bedöma patientens mentala status. Utbildning och att medvetandegöra problemet kan leda till att dysfunktionen upptäcks i ett tidigt skede, och behandlas mer framgångsrikt. Stud
Eutanasi-frågan diskuteras sedan decennier världen över. I dagens sjukvård då den medicinska tekniken gör det möjligt att förlänga livet, ställs vi inför svåra etiska ställningstaganden kring vem som ska avgöra när livet ska ta slut. Syftet med studien var att belysa hospissjuksköterskors tankar kring eutanasi. Intervjuer gjordes med nio sjuksköterskor verksamma inom hospis i södra Sverige. Result
