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A growing number of inherited disorders causing severe and progressive neurological deficits are linked to peroxisomal dysfunction. More than 15 peroxisomal diseases with neurological manifestations and some of them with dysmorphic features are identified. The diseases are classified into three groups depending on some similarities in the pathophysiology of the diseases within each group: defectiv
In the concluding chapter, we outline the major findings from the eleven book chapters by connecting them to one another. We come back to the triadic delegation and accountability relationship between candidates, voters and parties that were developed based on principal–agent theory, and emphasise the most relevant findings of this book that inform this triad. The chapter also takes a critical sta
BACKGROUND: Legumes are one of the most common foods causing allergic reactions in children and adults. Cross-reacting antibodies are frequently demonstrated in this family but the real clinical cross-reactivity is uncommon. OBJECTIVE: To report a case of lupine-induced anaphylaxis and to elucidate in vivo and in vitro cross-reactivity with some legumes. METHODS: Skin prick test (SPT) with some le
The UV photodissociation (<5 eV) of diiodomethane (CH(2)l(2)) is investigated by spin-orbit ab inito calculations. The experimentally observed photodissociation channels in the gas and condensed phases are clearly assigned by multi-state second-order multiconfigurational perturbation theory in conjunction with spin-orbit interaction through complete active space-state interaction potential energy
Indapamide is a nontiazidic sulfonamide diuretic which has not been previously reported as a cause of fixed drug eruption. We describe a patient who experienced several episodes of fixed drug eruption during treatment with indapamide. The diagnosis was confirmed by positive controlled oral challenge test. The possible existence of cross-reactivity with other sulfonamide derivatives was investigate
Development of artificial neural network (ANN) models using real plant data for the prediction of fresh steam properties from a brown coal-fired boiler of a Slovenian power plant is reported. Input parameters for this prediction were selected from a large number of available parameters. Initial selection was made on a basis of expert knowledge and previous experience. However, the final set of inp
Understanding of the elastic pressure/volume (Pel/V) curve is still limited in health and disease. The aim of the present study was to elucidate the Pel/V curve and elastance of the respiratory system (ERS) lung (EL) and chest wall (ECW) in healthy pigs. Six young (20.8 kg) and seven adult (58.9 kg), anaesthetized, paralysed and ventilated pigs were studied. Pel/V curves were recorded at zero end-
Buildings are one of the largest consumers of energy and materials, and hence they are also one of the largest contributors to negative environmental impacts. Traditionally, energy consumed by buildings during their operation phase was the most significant in their lifecycles and far exceeded the embodied energy. However, in contemporary low-energy buildings, the embodied energy is proportionally
Aquaporins are transmembrane proteins that facilitate the flow of water through cellular membranes. An unusual characteristic of yeast aquaporins is that they frequently contain an extended N terminus of unknown function. Here we present the X-ray structure of the yeast aquaporin Aqy1 from Pichia pastoris at 1.15 Å resolution. Our crystal structure reveals that the water channel is closed by the N
The electronic spectrum of the blue copper protein plastocyanin has been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method). The six lowest electronic transitions have been calculated and assigned with an error of less than 2000 cm-1. The singly occupied orbital in the ground state is Cu 3d-S(Cys) 3pπ antibonding with some N(His) 2pσ character. The brigh
To characterise geographical distribution and time trends of chronic kidney disease (CKD) mortality in the context of the epidemic of Mesoamerican nephropathy (MeN), likely related to occupational heat stress and other, unknown, factors.
OBJECTIVE: To explore the relationships between C-reactive protein (CRP), metabolic syndrome (MetS) and incidence of severe knee or hip osteoarthritis (OA) in a prospective study. METHODS: A population-based cohort (n=5171, mean age 57.5+/-5.9 years) was examined between 1991 and 1994. Data was collected on lifestyle habits, measures of overweight, blood pressure as well as high-density lipoprotei
This master thesis studies what happens when the labour market norms and the society norms meet law in the labour law books. Despite "law in the books" ensuring equal treatment of workers and non-discrimination in the access to jobs, research seems to indicate that societal norms play a role when persons try to enter the labour market. This thesis focuses on racial minorities, who are la
This report is made in order to evaluate the safety, in case of a fire, of personnel and patients in the surgical facilities at Helsingborg General Hospital. The problem that arises in this report is regarding the evacuation of patients that are undergoing surgery. This is a problem since it can take up to 60 minutes to finish a surgery and make a patient ready for evacuation. To determine the fir
This text deals with a problem concerning processes of the productive power of knowledge. We draw on so called poststructural theories challenging the classical image of thought – as hinged upon a representational logic identifying entities in a rigid sense – when formulating a problem concerning the gap between knowledge and the object of knowledge. More specifically we are looking at this proble
Migration har länge förekommit och anledningarna till förflyttningen kan variera. En grupp av människor som nyligen fått ökad uppmärksamhet är så kallade ”klimatflyktingar”. Termen grundar sig i att dessa människor flytt undan klimatförändringarnas effekter. Vi människor är en stor bidragande faktor till klimatförändringarna, främsta orsaken är koldioxidutsläpp. Klimatförändringarna väntas få flerDuring many years, migration has been a part of people’s life and the reasons for migration have varied. One group of migrants that has become larger in recent years is the “climate refugees”. This concept has its foundation in the fact that these humans are forced to flee from the effects of climate changes. Humans are a big contributing factor to climate changes, mostly due to the large amount o
We consider the Whitham equation u t +2uu x +Lu x =0, where L is the nonlocal Fourier multiplier operator given by the symbol m(ξ)=tanhξ/ξ. G. B. Whitham conjectured that for this equation there would be a highest, cusped, travelling-wave solution. We find this wave as a limiting case at the end of the main bifurcation curve of P-periodic solutions, and give several qualitative properties of
Background and purpose — Pooling data of studies evaluating total knee arthroplasty migration using radiostereometric analysis (RSA) may be compromised when the RSA method used would influence estimated differences between groups. We therefore reanalyzed a marker-based RSA study with model-based RSA to assess possible limitations of each RSA method, including insert micromotions in modular TKA and
