Filtyp
We consider the problem of approximating functions by sums of few exponentials functions, either on an interval or on the positive half-axis. We study both continuous and discrete cases, i.e. when the function is replaced by a number of equidistant samples. Recently, an algorithm has been constructed by Beylkin and Monzón for the discrete case. We provide a theoretical framework for understanding
Tasquinimod is an anti-tumor drug that is currently in clinical development for the treatment of solid cancers. After oral administration, tasquinimod and a number of its metabolites are excreted in the urine. The quantitative determination of tasquinimod in urine is challenging because of the required sensitivity (down to 0.1nM or 40pg/mL), the highly variable nature of this biological matrix and
PTEN is an important tumor suppressor gene that antagonizes the oncogenic PI3K/AKT signaling pathway and has functions in the nucleus for maintaining genome integrity. Although PTEN inactivation by mutation is infrequent in breast cancer, transcript and protein levels are deficient in >25 % of cases. The E3 ubiquitin ligase NEDD4 (also known as NEDD4-1) has been reported to negatively regulate PTE
Song divergence between populations of a species can lead to reproductive isolation and speciation. However, birds may have different singing styles used in distinct social contexts, and songs of each style may change at different rates over time and space. Here, we tested whether song divergence between subspecies of reed bunting, Emberiza schoeniclus, differs with singing style, by comparing son
Electronic waste (e-waste) in modern society is a growing issue that creates risks by degrading natural resources, through the production of the electronic devices in question, but also at a later end-of-life stage when recycled irresponsibly; by harming individuals directly – those who partake in the recycling, but also indirectly when deadly toxins from recycling flow into water and soil sources
Anxiety disorders are some of the most prevalent disorders in modern times and often seriously impact the daily lives of sufferers. Although there is an abundance of research investigating potential links between anxiety and threat response, there is a lack of study into the nuanced relationships between different anxiety types and threat types. In addition, there are considerable limitations to m
Transformation projects still tend to focus on buildings that once had life. This thesis aims to work with those that were never brought to it. In today’s world, there are an increasing amount of projects that garner a lot of attention and investment quite quickly. Some of these are taken through to the design stage and into development, only for them to suddenly not be viable. Development quickl
The total potential energy surfaces of several thallium, gold, iridium and rhenium odd-mass isotones are calculated microscopically as functions of the quadrupole deformation epsilon 2, when the odd protons occupy definite orbitals. The nuclear shapes and the static equilibrium deformations of these nuclei are deduced from the results of these calculations for the proton orbitals nearest to the Fe
Regenerated silk fibroin (RSF), obtained from the silk fibers of the species Bombyx mori, is a promising biomaterial due to its excellent mechanical and biological properties, as well as presenting versatility for applications in tissue engineering. This is particularly evident through the development of scaffolds via the 3D printing process. The viscosity of RSF solutions can be controlled by add
This article studies local enactments of “smart” in and through visions of six smart district development projects. We show that smart cities’ framings of the future are inevitably diverse, emerging from local assemblages consisting of a wide array of heterogeneous elements that translate global imaginaries of the smart city to meet local specificities, needs and agendas. We demonstrate that visio
Research on assortative mating often focuses on status achievement, particularly education, with status ascription becoming a progressively less important factor throughout the 20th century. Neighborhoods have been considered a kind of status ascription, since they are inherited from parents. Although neighborhoods can be important for preference formation for spousal characteristics and social gr
Over the past fifteen years, Rwanda has made significant progress in formalizing mining rights and the production processes of 3Ts minerals in its artisanal and small-scale mining (ASM) sector. However, labour relations remain largely unregulated. This study analyses ASM activities through the production process observations, document reviews, and interviews with key informants involved in the sec
This paper reflects on the challenges and opportunities of academic freedom monitoring from an advocacy perspective. Based on the review of two existing academic freedom indexes and the author's experience building scientific freedom indicators, the paper discusses three challenges: conceptual, methodological, and political. The conceptual challenges are of four kinds: undertheorization, complexit
På sociala medier tar människor sig friheter när det gäller användningen av bilder på barn, och det framförallt inom humanitära organisationer och företag. Bilden på barnet, används som ett politiskt verktyg för förändring och som en empatiförhöjare för att få målgrupper att agera. Fenomenet är något som numera även syns bland kändisars och influerares sociala plattformar, vilket skapar en stor sp
A high excess mortality is well described after hip fracture. Deaths are in part related to comorbidity and in part due directly or indirectly to the hip fracture event itself (causally related deaths). The aim of this study was to examine the quantum and pattern of mortality following hip fracture. We studied 160,000 hip fractures in men and women aged 50 years or more, in 28.8 million person-yea
To study the causes of agricultural declines in south-west Sweden, a multi-proxy study including pollen analysis, bog surface wetness indicators and aeolian sediment influx reconstructions was carried out on the Store Mosse Bog, situated on the coastal plain of Halland. Patterns of agricultural changes during the past 6,000 years from this study were compared to one additional site on the coastal
Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese po
A localized dehydration zone, Sondrum stone quarry, Halmstad, SW Sweden, consists of a central, 1 m wide granitic pegmatoid dyke, on either side of which extends a 2.5-3 m wide dehydration zone (650-700 degrees C; 800 MPa; orthopyroxene-clinopyroxene-biotite-amphibole-garnet) overprinting a local migmatized granitic gneiss (amphibole-biotite-garnet). Whole-rock chemistry indicates that dehydration
