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The present study deals with free play in preeschool. The purpose is to investigate the way children conceptualize play, and the significance of play in preeschool activities. The latter has been illuminated through an analysis of normative documents, and vatious methods have been worked out that show how the possibilities of play can be made use in preschool. Group interviews with children betwee
Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di-or trimethylated at Lys 4 and H3K27me3; histone H3 trim
Manuel Castells’ notion of the city in the 1980s as a social product resulted from contradiction of interests and values is getting more evidenced recently. This indicates the need to understand the contemporary urban lives from various area of inquiry, including the everyday life of city dwellers of the so-called creative city like Bandung in West Java, Indonesia. Despite the debates on creative
Det huvudsakliga syftet med den här uppsatsen var att ta reda på om den internationella handelsvaran programformat är möjlig att skydda i Sverige utifrån upphovsrättslig reglering och marknadsrättslig reglering avseende renommé. Jag har valt att använda mig av traditionell juridisk metod där rättskällorna lagtext, rättspraxis, förarbeten och doktrin ligger till grund för min undersökning. För en bThe main purpose of this essay was to find out if program formats are possible to protect in Sweden based on copyright regulation and market legal regulation regarding reputation. I have used the traditional legal method which contains legal sources, legal texts, case law, its legislative history and doctrine is the basis for my investigation. For a broader understanding a Media and Communication
Purpose: Hexokinase 1 (HK1) encodes a ubiquitously expressed hexokinase, which is responsible for the first step of glycolysis, phosphorylation of glucose to glucose-6-phosphate. Both autosomal recessive and dominant variants in this gene have previously been shown to cause human disease, and presently, there are clinical data available for 27 individuals with the monoallelic neurodevelopmental di
Amid the rapid expansion of the global digital economy, the European Union faces a fundamental tension between promoting digital trade liberalisation and safeguarding its regulatory autonomy. This thesis examines how policy space provisions within the EU's new, standalone Digital Trade Agreements (DTAs) with Singapore and South Korea relate to this strategic challenge. Using a legal doctri-nal
Black-box policy optimization is a class of reinforcement learning algorithms that explores and updates the policies at the parameter level. This class of algorithms is widely applied in robotics with movement primitives or non-differentiable policies. Furthermore, these approaches are particularly relevant where exploration at the action level could cause actuator damage or other safety issues. H
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activ
Swelling is the most fundamental property of graphite oxides (GO). Here, a structural study of Brodie graphite oxide (BGO) swelling in a set of long chain 1-alcohols (named C11 to C22 according to the number of carbons) performed using synchrotron radiation X-ray diffraction at elevated temperatures is reported. Even the longest of tested alcohols (C22) is found to intercalate BGO with enormous ex
Recombinant adeno-associated viral vectors (rAAVs) have become an industry-standard technology in the field of gene therapy, but there are still challenges to be addressed in their biomanufacturing. One of the biggest challenges is the removal of capsid species other than that which contains the gene of interest. In this work, we develop a mechanistic model for the removal of empty capsids—those t
Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like a
This edited work draws on a range of contributed expertise to trace the fortune of an Aristotelian thesis over different periods in the history of philosophy. It presents eight cases of direct or indirect challenges to the Aristotelian passive account of human cognition, taking the reader from late antiquity to the 20th century. Chapters analyse the (often indirect) effect of Aristotle’s account o
The evolution and maintenance of color clines is a classic topic of research in evolutionary ecology. However, studies analyzing the temporal dynamics of such clines are much less frequent, due to the difficulty of obtaining reliable data about past color distributions along environmental gradients. In this article, we describe a case of decades-long temporal stability and directional change in a
Advancing the use of air-sensitive polar organometallic Grignard and organolithium reagents under more environmentally benign conditions, here we report the addition of these reagents to a-b unsaturated ketones and aldehydes using the deep eutetic solvent (DES) choline chloride (ChCl): glycerol (Gly) (1:2), under air. Reactions occur at room temperature within seconds with excellent regioselective
Aim: To describe what is known about hip problems in individuals with developmental central hypotonia. Method: Searches were conducted in five databases to October 2023. Down syndrome was excluded from this analysis of less well-known genetic diagnoses. At least two reviewers independently screened titles, abstracts, read full-text articles, and extracted data. Results: Of 89 full-text articles, 7
