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Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f
Six rotational bands up to energies Ex = 24.7 MeV and spins Jπ=(79/2−) have been identified in 109Sn using the GAMMASPHERE γ-detector array. Four of the bands show smoothly decreasing dynamic moments of inertia at rotational frequencies ℏω > 0.6 MeV. The bands arise at medium spins from a coupling of a valence d5/2, g7/2 or h11/2 neutron to the deformed 2p2h proton excitation of the Z=50 core 108S
BACKGROUND: Dapagliflozin improved cardiometabolic outcomes following myocardial infarction in patients without prior type-2 diabetes (T2DM) in the DAPA-MI (dapagliflozin in patients with myocardial infarction) trial. The effect of glycemic status and body mass index (BMI) post–myocardial infarction requires elucidation. METHODS: Participants with T2DM diagnosis, without baseline hemoglobin A1c, o
Popular Abstract in Swedish Inom ramen för detta forskningsprojekt har det utvecklats två resultat. En operativ teknik – kallad ”Tool for Strategic Territorial Planning (TSTP)” – som hjälper stadsplanerare att visualisera och bättre informera beslutsfattare om vilka effekter olika åtgärder får på fattigdoms bekämpning, har utvecklats. Detta genom att med statistisk information som grund, framställFew planning practices in the South seem to be equipped with key concepts and technical, empirical and administrative capacities required to comprehend and visualize the phenomenon of poverty at inter- and intra-urban levels, which compromises their ability to inform decision-makers on the effects on poverty reduction of the land-based actions they design, implement and monitor. This challenge wa
Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accurac
The objective was to develop evidence -based recommendations and a research and educational agenda for the non-pharmacological management of hip and knee osteoarthritis (OA). The multidisciplinary task force comprised 21 experts: nurses, occupational therapists, physiotherapists, rheumatologists, orthopaedic surgeons, general practitioner, psychologist, dietician, clinical epidemiologist and patie
Objectives To describe clinical history and ultrasound findings in patients with tubal carcinoma. Methods Patients with a histological diagnosis of tubal cancer who had undergone preoperative ultrasound examination were identified from the databases of 13 ultrasound centers. The tumors were described by the principal investigator at each contributing center on the basis of ultrasound images, ultra
Objectives To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE). Methods Genotyping of 1163 European SLE patients and 1482 controls and imputation were performed covering the BLK gene with 158 single-nucleotide polymorphisms. Logistic regression analysis was done using PLINK and conditional analyses usin
Calcium phosphate materials (CaPs) have proven biocompatible and useful in clinical situations. One CaP showing promise in the clinic is alpha phase tricalcium phosphate ([alpha]-TCP). [alpha]-TCP in powder form can be hydrated and undergoes a reaction resulting in calcium deficient hydroxyapatite (CDHA). The similarity of CDHA and human bone makes [alpha]-TCP a very viable material for applicatio
Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.
To analyse the differences between patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) entered into randomised clinical trials (RCTs) and those followed in large observational cohorts.
Purine nucleoside phosphorylase (PNP) deficiency is a rare form of autosomal recessive combined primary immunodeficiency caused by a enzyme defect leading to the accumulation of inosine, 2'-deoxy-inosine (dIno), guanosine, and 2'-deoxy-guanosine (dGuo) in all cells, especially lymphocytes. Treatments are available and curative for PNP deficiency, but their efficacy depends on the early approach. P
Background: Terra preta do indio or 'dark earth' soils formed as a result of a long-term addition of organic matter by indigenous peoples in Amazonia. Aims: Here we report on the first study of productivity, allocation and carbon cycling from a terra preta plot in eastern Amazonia (Caxiuana, Para, Brazil), and contrast its dynamics with a nearby plot on infertile soil (ferralsols). Methods: We det
Research on ecosystem services has grown rapidly over the last decade. Two conceptual frameworks have been published to guide ecological assessments of organisms that deliver services-the concepts of service-providing units (SPUs) and ecosystem service providers (ESPs). Here, we unite these frameworks and present an SPU-ESP continuum that offers a coherent conceptual approach for synthesizing the
Popular Abstract in Swedish Avhandlingen behandlar inlärning av italienska som ett av två modersmål (svenska/italienska) hos tvåspråkiga barn och som andraspråk hos svenska vuxna som lär sig italienska i Italien. Särksilt fokus ligger på ett barn som lär sig italienska som ett av två modersmål i Sverige och vi ställer oss frågan om hans italienska kommer att utvecklas som hos italienska enspråkigaThis thesis deals with the development of the DP (the Determiner Phrase) in bilingual first (2L1) and in adult second (L2) language acquisition of Italian, with a focus on a case study of Italian as a second first language. The thesis suggests that the bilingual children and the Swedish adult learners develop the Italian DP differently. The child acquiring Italian as a second first language develo
The European Space Agency's Gaia satellite was launched into orbit around L2 in December 2013 with a payload containing 106 large-format scientific CCDs. The primary goal of the mission is to repeatedly obtain high-precision astrometric and photometric measurements of one thousand million stars over the course of five years. The scientific value of the down-linked data, and the operation of the on
Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell ge
