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OBJECTIVE: To understand aggrecan degradation in juvenile idiopathic arthritis (JIA), the pattern and abundance of aggrecan fragments in synovial fluid aspirates from JIA patients were analysed and compared with aggrecan fragments in synovial fluids from patients with other arthritides, juvenile knee injury and a knee-healthy reference group. METHODS: The concentration of sulphated glycosamino
Popular Abstract in Swedish Selen är ett essentiellt näringsämne som har många viktiga fysiologiska funktioner. Hos människor och djur utövar selen sin funktion bara om elementet är specifikt bundet i selenoproteiner som aminosyran selenocystein. Viktiga funktioner hos selenoproteiner är att verka som antioxidanter, upprätthålla redox-balansen i cellerna och reglera sköldkörtelhormonernas aktiviteSelenium is an essential nutrient and in animals and humans it can either be specifically incorporated into proteins as selenocysteine or randomly as selenomethionine. It can also occur as low-molecular-weight compounds and the form of selenium in foods may also influence food quality. The aims of the present studies were: to study selenium and other trace element compounds in milk and whey; to el
OBJECTIVE: To develop a Western blot method for quantification of multiple aggrecan fragments in human synovial fluids (SFs). METHOD: SF aggrecan fragments were prepared from knee healthy (reference), knee injury and arthritis subjects by CsCl gradient centrifugations collecting D1 fractions. Samples were analyzed by Western blot, using antibodies against the N-terminal epitope ARGS and the G3 dom
OBJECTIVE: To examine different aggrecanase generated fragments in synovial fluid (SF) from patients with acute and chronic knee injuries and from knee healthy subjects. METHODS: We prepared SF-D1 samples from acute (n=35) and chronic (n=35) knee injury patients and knee healthy subjects (n=10). Aggrecan fragments were analyzed in the SF-D1 samples by quantitative (G1, ARGS, KEEE and G3 antibodies
Popular Abstract in Swedish Selen är ett essentiellt näringsämne som behövs för att upprätthålla flera viktiga funktioner i kroppen, huvudsakligen genom en speciell grupp proteiner som heter selenoproteiner. Det finns minst 25 stycken olika selenoproteiner i människan och flera av dem skyddar kroppen mot oxidation medan vissa andra sköter regleringen av sköldkörtelhormoner. Många selenoproteiners Selenium is a micronutrient that is essential for many important life processes due to the action of the specific selenoproteins containing one or more of the 21st amino acid, selenocysteine. Twenty-five selenoprotein genes have been found in the human genome but the function of many of them is not yet known. Some of the characterised selenoproteins have, however, antioxidant properties. Selenium
Popular Abstract in Swedish Sambandet mellan exponering för miljögifter och mineraler i fosterlivet och risken att ha ADHD diagnos i barndomen ADHD (uppmärksamhetsstörning med hyperaktivitet) är en neuropsykiatrisk funktionsnedsättning som drabbar barn och kan fortsätta till vuxen ålder. Antalet barn som diagnosticerats med ADHD har ökat under senare år. Om detta beror på att man fått mer kunskapPerfluorinated compounds (PFCs), phthalates, manganese and selenium are ubiquitous in the environment and humans and influence fetal growth and development. Register and biobank based case-control studies were conducted to investigate the relationship between prenatal exposure to these chemicals and attention deficit hyperactivity disorder (ADHD) in childhood. The study base comprised children b
Popular Abstract in Swedish Allt levande består till stor del av proteiner. De bygger upp muskler och hår, transporterar syre i blodet och ser till att kemin i kroppen fungerar som den ska. Men hur tillverkas då dessa proteiner? Jo i alla celler finns ribosomer, proteinfabriker. En bakterieribosom är ungefär 0.02 mikrometer stor. Den är sammansatt av proteiner och RNA-kedjor. RNA utgör den funktioTranslation is a central biological process, that is catalysed by a machinery consisting of RNA and protein. In this thesis three different protein components of the bacterial protein synthesis system have been structurally studied. Ribosome recycling factor (RRF) is essential for the recycling step of the translation cycle, elongation factor SelB is a specialised elongation factor needed for co-t
Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients fro
Popular Abstract in Swedish Kost, livsstil, antioxidanter och riskfaktorer för cancer De flesta forskare är överens om att våra matvanor spelar en betydande roll för risken att insjukna i cancer. Däremot är forskarna inte överens om vad och hur man bör äta för att förebygga cancer. En populär teori under det senaste decenniet har varit den så kallade antioxidantiahypotesen. Man har förstått att This thesis examines associations between a number of epidemiological or biological markers of cancer risk and oxidative stress, in order to achieve a better understanding of how diet, lifestyle, and genetic factors contribute to the occurrence of oxidative stress. Data from the Malmö Diet and Cancer (MDC) cohort was used. The MDC study is a population-based cohort study which uses a detailed modi
The “new” LP3 was established as a center in June 2016 by the Faculty of Science, the Faculty of Medicine, and LTH, through the merger of the “old” LP3—specialised in protein production—and Lund University’s protein crystallisation facility. It is also now part of the National Infrastructure, Protein Production Sweden (PPS). The “new” LP3 was created as a center in June 2016 by the Faculty of Scie
https://www.lp3.lu.se/lp3-annual-report-2025 - 2026-10-01
Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infectio
Nine different germ-line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden, by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein-truncation test for exon 11, followed by direct sequencing. All but one of the mutations are predicted to give rise to premature translation terminat
BACKGROUND: Group 5 allergens, such as Phl p 5 of timothy grass, are major contributors to grass pollen allergy. Antibody 212597 specific for this allergen was recently isolated by single cell sequencing of bone marrow B cells of a grass pollen-allergic subject. This antibody, although subjected only to a low level of hypermutation resulting in six amino acid substitution across the heavy and ligh
The modified diet history methodology of the Malmö Diet Cancer cohort2016-09-05Edited by Elisabet Wirfält and Emily Sonestedt Resource persons:Dietary data collection at baseline: Ulrika Ericson (ulrika [dot] ericson [at] med [dot] lu [dot] se)Peter Wallström (especially supplements) (peter [dot] wallstrom [at] med [dot] lu [dot] se (peter[dot]vallstrom[at]med[dot]lu[dot]se)) Consultation on dieta
https://www.malmo-kohorter.lu.se/malmo-kost-cancer-mkc/mkc-kostmetod/mdc-diet-history - 2026-10-01
Popular Abstract in Swedish Mineraler fås från både fast och flytande föda. De senaste årtiondena har bordsvattenkonsumtionen ökat, och vattnets kemiska innehåll har alltmer kommit i fokus. Studier visar dessutom att grönsakers mineralinnehåll har minskat, vilket ökar betydelsen av mineralintag från annat håll. Den här doktorsavhandlingen omfattar fyra olika studier. I den första studien undersökMineral elements in drinking water have been in focus for more than a decade, especially as the habit of drinking bottled water has increased, not the least among young people. Minerals in drinking water have become more important since minerals in food, especially in vegetables, have decreased substantially the last decades. This thesis includes four different studies. In the first study 20 munic
Marinarkeolog från Lunds universitet ledde hämtning av pilot från andra världskriget Marinarkeolog från Lunds universitet ledde hämtning av pilot från andra världskriget Publicerad den 20 oktober 2021 Foto: Rich Stevenson En pilot från andra världskriget har begravts i hans hemstad i Maine, efter ett komplext projekt att bärga kroppen som letts av Lunds universitets arkeolog Brendan Foley. Piloten
Popular Abstract in Swedish Tandvårdens arbetsmiljö innehåller ett stort antal riskfaktorer som anses medföra exponering som genom sin skadliga inverkan kan ge upphov till symptom och på längre sikt ohälsa. Det gäller såväl fysiska, kemiska som psykosociala faktorer. Det är känt sedan länge att tandläkare utvecklar besvär från rörelseorganen, som anses vara arbetsrelaterade. Patienten behandlas iThe aim of the thesis was to focus on the occupational health risks in dentistry with emphasis on musculoskeletal disorders in the neck and upper limbs and neuropathy in the hands, in relation to exposure to physical workload, vibration and mercury. An increased high frequency of long-lasting and wide-spread musculoskeletal symptoms in the neck and shoulder regions (58-75% during the past 12 mont
1 Developments in epidemiology and biomarker research A life-course perspective 21-22 March 2019 Skåne University Hospital (SUS), Malmö, Sweden Organisers: The Strategic Research Area (SRA) Epidemiology for Health (EpiHealth) at Lund and Uppsala Universities in collaboration with OLINK Proteomics AB, Uppsala, Sweden 2 Welcome address! Dear colleagues, You are all very welcome to this 2-day symposi
Popular Abstract in Swedish Mellanörats funktion är att överföra och förstärka ljudvågor från luften i hörselgången till innerörats vätska. Denna överföring är optimal när trumhinnan är i neutral position, dvs när trycket i mellanörat och omgivningen är lika. Avvikelser i mellanörats tryck ses vid kroniska mellanöresjukdomar, fr a är det visat ett samband mellan negativt tryck och sjukdomstillstånThe middle ear (ME) pressure is regulated by gas diffusion over the ME mucosa and pressure equalizations via the Eustachian tube (ET). Disturbance in the regulation of ME pressure is believed to contribute to the development of chronic ear diseases. In this work subjects with chronic central perforation (CCP), healthy ears with ventilation tubes (VTs), attic cholesteatoma (AC) and Meniere’s diseas
Popular Abstract in Swedish Tjocktarmcancer är en av de vanligaste cancerformerna i västvärlden. I Sverige drabbas årligen ca 5000 människor. Ungefär 10% av fallen går att härleda till ärftliga faktorer medan den övervägande delen orsakas av miljöfaktorer. Kända riskfaktorer är fysisk inaktivitet, fetma och rökning. Risken för cancer påverkas dock mest av den kost vi äter. Allmänt kan sägas att enSphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. The thesis studied the distribution pattern, the species difference and the clinical implicatio
