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Genetic control of collagen-induced arthritis in a cross with NOD and C57Bl/10 mice is dependent on gene regions coding for complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes.

The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren′s syndrome. To investigate whether NOD genes also promote autoimmune-mediatedarthritis we established a NOD strain with an MHC class II fragment containing the Aq class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contr

New perspectives on complement mediated immunotherapy

Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to

BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

Analysis of the molecular interplay between Streptococcus pyogenes and its human host

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib

Derivation of efficiency factors for uneven irradiation on a fin absorber

In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency

Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy

Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i

Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha

Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel

Two major classes in the M protein family in group A streptococci

The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh

Investigation on the effects of fly ash particles on the thermal radiation in biomass fired boilers

Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f

Pi-gp.fd08poster

Poster Fechner Day 2008 Introduction Fechner (1801-1887) first discovered that when two stimuli are presented for comparison people systematically overestimate the magnitude of one stimulus and underestimate the magnitude of the other; termed, time-order effect (TOE) for stimuli separated by a time interval, and space-order effect (SOE) for stimuli separated spatially. Asymmetries in sensory discr

https://www.psy.lu.se/en/sites/psy.lu.se.en/files/pi-gp.fd08poster.pdf - 2026-05-02

Education

IEA offers a number of courses in industrial electrical engineering and automation both in Lund (for several 5-year engineering programmes) and at Campus Helsingborg for the 3-year engineering programme in Electrical Engineering with Automation (lth.se, in Swedish).Links to course plans open on Course website LTH. Links to more in-depth information open in Canvas. Compulsory courses in Lund Electr

https://www.iea.lth.se/en/education - 2026-05-01

Begreppet rättssäkerhet och den nya migrationsprocessen : en begreppsanalys av språkbruket kring rättssäkerhet i förarbetet till och i utvärderingen av 2006 års svenska migrationsreform

The purpose of this academic paper is to analyze the use of language in the government bill and the official reports by the Swedish Government regarding the reform on the field of migration - the documents that are used as primary sources for this paper. The reform, that was put into practice in 2006, led to a new Swedish Aliens Act and a reorganization in the migration and asylum procedure, and w

Kgkym eng

Programme Syllabus 1. IDENTIFICATION • Name of programme: Bachelor’s Programme in Church Music • Scope of programme in higher education credits: 180 higher education credits. • Cycle: First • Programme code: KGKYM. 2. DETAILS OF APPROVAL Syllabus approved by the Board of the Faculty of Fine and Performing Arts 18 October 2017. This syllabus is valid from the autumn semester 2017. 3. PROGRAMME DESC

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/kgkym_eng.pdf - 2026-05-02

Newkgkym eng

Programme Syllabus 1. IDENTIFICATION • Name of programme: Bachelor’s Programme in Church Music • Scope of programme in higher education credits: 180 higher education credits. • Cycle: First • Programme code: KGKYM. 2. DETAILS OF APPROVAL Syllabus approved by the Board of the Faculty of Fine and Performing Arts 18 October 2017. This syllabus is valid from the autumn semester 2017. 3. PROGRAMME DESC

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/newkgkym_eng.pdf - 2026-05-02

European Centre for SI-PASS

Upcoming events Staff and supervisorsSupervisor trainingGet to know SI-PASSOnline supervisor fika Student SI-PASS leadersLeader development activities Connect with us on LinkedIn Join us on LinkedIn for news and updates. Welcome to the European Centre for SI-PASS! The European Centre for SI-PASS helps implement and develop Supplemental Instruction - Peer Assisted Study Sessions (SI-PASS) throughou

https://www.si-pass.lu.se/european-centre-si-pass - 2026-05-01